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Therapeutics - Biotech

ALERT BAR

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Methods of Diagnosing Leiomyoma by Measuring Catechol-O-methyltransferase
Ayman Al Hendy, MD, PhD

Miniprotein Ligands and Other Polypeptides and Methods For Making and Using Same
Robert Fox, PhD; Alan D. Barrett, PhD; Xiuzhen Fan, PhD; Michael Holbrook, PhD

IKK Gamma Gene Products and Methods for Making and Using Same
Allan Brasier, MD; Tao Hai, PhD; Thomas Wood, PhD; Yuanfen Wei

Methods of Treating Lung Inflammation
Antonella Casola, MD; Roberto Garofalo, MD; Allan Brasier, MD

Methods and Materials for Treating Autoimmune Diseases and Conditions
Premkumar Christadoss, MD; Erdem Tuzun, MD

Use of Thiazolidinediones Derivatives for Preventing Uterine Contractions In Premature Labor or Lactation
John A. Copland, PhD; Kirk L. Ives; Melvyn Soloff, PhD

High-Throughput Assay for Virus Entry and Drug Screening
Robert A. Davey, PhD; Andrey Kolokoltsov, MS

Radiation and Nanoparticles for Enhancement of Drug Delivery in Solid Tumors
Rinat O. Esealiev, PhD

SIRNA Inhibition of PI3K P85, P110, and AKT2 and Methods of Use
B. Mark Evers, MD; Piotr G. Rychahou, MD, PhD

Large Scale Production of Packaged Alphavirus Replicons
Ilya Frolov, PhD; Elena Frolov, PhD

Uses of Tetrahydrobiopterin for Treating Gastroparesis
Pankaj J. Pasricha, MD; Pandau R. Gangula, PhD

Troglitazone Compounds for Treating Climacteric and Cancer
Randall J. Uban, PhD; Allan Green, PhD

Methods and Materials for Pain Management
Li-Yen Mae Huang, PhD; Yanping Gu, PhD; Ya Xu, MD

Methods and Compositions for Vaccination Against or Involving Enterobacteriaceae Bacteria
Gary R. Klimpel, PhD; David W. Niesel, PhD; Ashok Chopra, CSc, PhD; Jian Sha, MD, MS

Reverse Genetic System for Rift Valley Fever Virus and Uses Thereof
Shinji Makino, DVM, PhD; Tetsuro Ikegami, PhD; Clarence J. Peters, MD; Sungyong Won, PhD

Methods and Compositions for Delivering Enzymes and Nucleic Acid Molecules to Brain, Bone and Other Tissues
Reuben Matalon, MD, PhD

Methods and Compositions for the Treatment of Attention Deficit Hyperactivity Disorder and Hyperphenylalanemia
Reuben Matalon, MD, PhD; Ofer Matalon, PhD

Use of CD63 Inhibitors
William A. O'Brien, MD; Kathie Grovit-Ferbas, PhD

Treatment of Disorders By Implanting Stem Cells and/or Progeny Thereof Into Gastrointestinal Organs
Pankaj J. Pasricha, MD; Maria-Adelaide Micci, PhD

Method of Identifying Antinociceptive Compounds Using Protease Activated Receptor-2
Pankaj J. Pasricha, MD; Willemijntje A. Hoogerwerf, PhD; John Winston, PhD; Maria-Adelaide Micci, PhD; Helen Hellmich, MD; Mohan Shenoy, PhD

Treatment of Irritable Bowel Syndrome and Related Bowel Diseases
Pankaj J. Pasricha, MD

Method of Increasing Gastric Emptying
Pankaj Jay Pasricha, MD; Maria-Adelaide Micci, PhD

Polypeptide That Interacts With Heat Shock Proteins
Winston C. Patterson, MD; Carol A. Ballinger, PhD

3' Sequence of the GB Virus B (GBV-B) Genome
David V. Sangar, PhD; Stanley M. Lemon, MD

Methods and Compositions Involving Nucleotide Repeat Disorders
Partha Sarkar, PhD; Tetsuo Ashizwa, MD; Weidong Xu, PhD

Method for Designing a Potential Inhibitor of Glutathione-Aldehyde Conjugate Binding To Aldose Reductase
Satish K. Srivastava, PhD; Aurni Bhatnagar, PhD; Kota V. Ramana, PhD

Thermostable UvrA and UvrB Polypeptides and Methods of Use
Bennett Van Houten, PhD; Milan Skorvaga, PhD

Plasmodium Sp. Chitinase
Joseph M. Vinetz, MD

Rickettsia Felis Outer Membrane Protein
Donald H. Bouyer, PhD; Patricia Crocquet-Valdes; John Stenos, PhD; David H. Walker, MD

Viral Pseudo-Capsids Including Assembly Agonists and Antagonists
Stanley J. Watowich, PhD; Meghan Kunkel, PhD; Marta Lorinczi, PhD

Method of Producing Region-Specific Neurons From Human Neuronal Stem Cells
Ping Wu, MD, PhD

Phosphorylation of 5-lipoxygenase at ser523 and Uses Thereof
Yochi Birnbaum, PhD

Methods of Increasing cAMP levels and Uses Thereof
Yochi Birnbaum, PhD

Uses of Selective Cyclooxygenase-1 Inhibitors
Yochi Birnbaum, PhD

Inhibition of Inositol 1,4,5-Triphosphate Receptor Calcium Channel/Cytochrome c Interactions and Uses Thereof
Darren F. Boehning, PhD; Jose M. Barral, MD, PhD

Methods for Inhibiting Allergic Inflammation and Other Responses Initiated by Pollens, Molds, and Other Non-Animal Derived Allergens
Istvan Boldogh, PhD; Sanjiv Sur, MD

Method and Biomarkers for the Detection of Dengue Hemorrhagic Fever
Tadeusz Kochel, PhD; Josefina Nores Garcia, PhD; Allan Brasier, MD; Adrian Recinos, PhD; John E Wiktorowicz, PhD; Heidi Spratt, PhD; Hyunsu Ju, PhD

Novel Small Chemical Inhibitors for Exchange Protein Directly Activated by cAMP (EPAC)
Xiaodong Cheng, PhD; Jia Zhou, PhD; Tamara Tsalkova, PhD; Fang Mei, PhD; Haijun Chen, PhD

Production of and Uses for Decellularized Lung Tissue
Joaquin Cortiella, MD; Joan E. Nichols, PhD; Jean A. Niles

Inhibition of Filovirus Entry Into Cells and Uses Thereof
Robert A. Davey, PhD; Andrey A. Kolokoltsov, PhD; Mohammad F. Saeed, PhD

Methods and Compositions Related to a Triple Combination Cancer Therapy
Jianli Dong, PhD; Gengming Huang, PhD

UNC-45A Splice Variants Based Cancer Diagnostics and Therapeutics
Henry Fredric Epstein, MD; Wei Guo, PhD.; Daisi Chen, PhD; Ram Singh, PhD

Ultrasound-Based Treatment Methods for Therapeutic Treatment of Skin and Subcutaneous Tissues
Rinat O. Esenaliev, PhD

Noninvasive Therapies In the Absence or Presence of Exogenous Particulate Agents
Rinat O. Esenaliev, PhD

Attenuation of Encephalitogenic Alphavirus and Uses Thereof
Ilya V. Frolov, PhD; Elena Frolova, PhD; Scott C. Weaver, PhD

Chimeric Chikungunya Virus and Uses Thereof
Ilya V. Frolov, PhD; Scott C. Weaver, PhD; Eryu Wang, MD, PhD

Uses of Morelloflavone
Kenichi Fujise, MD; Nongporn Towatana, PhD; Wilawan Mahabusarakam, PhD

Diagnosis and Treatment of Trypanosoma Cruzi Infection and Chagas Disease
Nisha J. Garg, PhD

Antibody-Mediated Modulation of Allergy
Randall M. Goldblum, MD; Terumi Midoro-Horiuti, MD, PhD; Bo Ning, PhD; Ruby Tiwari, PhD

Chikungunya Virus Infectious Clones and Uses Therefor
Stephen T. Higgs, PhD; Dana L. Vanlandingham, PhD; Konstantin Tsetsarkin, PhD

Upregulation of Opioid Receptors for Pain Management
Li-Yen Mae Huang, PhD; Yanping Gu, PhD

Methods and Compositions for Treatment of Reperfusion Injury and Other Cardiac Conditions
Ming-He Huang, PhD; Yochai Birnbaum, PhD; Barry F. Uretsky, MD

Reducing Myocardial Reperfusion Injury by the Combination Therapy of Protein Kinase A Activation and B1-Adrenegic Receptor Blockade
Ming-He Huang, PhD; Yochai Birnbaum, PhD; Barry F. Uretsky, MD

Inhibitor of dsRNA-Dependent Protein Kinase (PKR) as an Enhancer of Bunyavirus Live-Attenuated Vaccines
Tetsuro Ikegami, PhD; Birte Kalveram, PhD; Sabarish Indran, PhD; Olga Lihoradova, PhD; Alexander Freiberg, PhD

Compositions and Methods Related To Poloxamer Copolymer Membrane Sealant
Rakez Kayed, PhD

Antibodies That Bind Tau Oligomers
Rakez Kayed, PhD

Antibodies That Bind Amyloid Oligomers
Rakez Kayed, PhD

Methods and Compositions for Treating Phenylketonuria
Reuben Matalon, MD, PhD

Ex Vivo Human Lung/Immune System Model Using Tissue Engineering for Studying Microbial Pathogens With Lung Tropism
Joan E. Nichols, PhD; Joaquin Cortiella, MD; Ronald P. Mlcak, PhD; Jean A Niles

Autologous Somatic Cells from Peripheral Blood and Uses Thereof
Joan E. Nichols, PhD; Joaquin Cortiella, MD; Jean A. Niles; Eric Lee, PhD; Donald Prough, MD

Antagonists of the Transient Receptor Potential Vanilloid 1 and Uses Thereof
Jiande Chen, PhD; Pankaj Jay Pasricha, MD; Rami Hawari, PhD

Transient Receptor Potential Vanilloid 1 and Uses Thereof
Pankaj J. Pasricha, MD; John H. Winston, PhD

Neurotoxin Therapy for Postprandial Hyperglycemia
Pankaj J. Pasricha, MD

Modulation of Nerve Pain Activity by Resiniferatoxin and Uses Thereof
Pankaj J. Pasricha, MD

Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof
Irina A. Pikuleva, PhD; Natalia V. Mast, PhD

Treatment for Neuropathic Pain Due to Spinal Cord Injury
Regino Perez-Polo, PhD

S-Nitrosylation of Glucosylating Toxins and Uses Therefor
Tor C. Savidge, MD; Jonathan Stamler, PhD

Novel Allosteric Therapeutics for Clostridium Difficile Infection (CDI)
Tor C. Savidge, MD

Physicochemical (PCP) Based Consensus Sequences and Uses Thereof
Catherine H. Schein, PhD; Petr Danecek, PhD

Methods Involving Aldose Reductase Inhibitors-Sepsis
Satish K. Srivastava, PhD; Venkat Ramana, PhD; Aruni Bhatnagar, PhD

Treatment of Cancer with Aldose Reductase Inhibitors (Colon, Lung, Breast and Prostate Cancer)
Satish K. Srivastava, PhD; Kota V. Ramana, PhD

Methods Involving Aldose Reductase Inhibitors
Satish K. Srivastava, PhD; Kota V. Ramana, PhD

Methods for Treating COPD
Satish K. Srivastava, PhD; Kota V. Ramana, PhD; Umesh C. Yadav, PhD

Bcl-2 Promoted Cell Death
Giulio Taglialatela, PhD; Bryce Portier, PhD

Method of Diagnosing and Treating Ehrlichia
David H. Walker, MD; Sunil Thomas, PhD

Diagnosis and Treatment of Erlichiosis
Sunil Thomas, PhD; David H. Walker, MD

Compositions and Methods for Preventing or Treating Burkholderia Infection
Alfredo G. Torres, PhD; D. Mark Estes, PhD

Regulation of Brain Natriuretic Peptide and Catecholamines for the Treatment of Cardiovascular Diseases
Ming-He Huang, MD, PhD; Barry Uretsky, MD

Fusogenic Virus-like Particles and Uses Thereof
Pramila Walpita, PhD

Small Molecule Inhibitors of Dengue and West Nile Virus Proteases
Stanley J. Watowich, PhD; Suzanne M. Tomlinson, PhD; Scott Gilbertson, PhD

Chimeric Sindbis-Eastern Equine Encephalitis Virus and Uses Thereof
Ilya Frolov, PhD; Patricia V. Aguilar, PhD; Scott C. Weaver, PhD; Slobodan Paessler, DVM, PhD

Chimeric Sindbis-Western Equine Encephalitis Virus and Uses Thereof
Ilya Frolov, PhD; Scott C. Weaver, PhD

Single Stranded DNA Aptamers Binding NF-kB/RelA
Steven G. Widen, PhD; Thomas G. Wood, PhD; Allan R. Brasier, MD; Yingxin Zhao, PhD

Sheep Model of Neuropathic Pain Behavior and Uses Thereof
Denise M. Wilkes, PhD; Li-Yen M. Huang, PhD

Allosteric Modulators of 5-Hydroxytryptamine 2C Receptor (5-HT2CR)
Jia Zhou, PhD; Chunyong Ding, PhD; Kathryn A. Cunningham, PhD

Bivalent AMPA Receptor Positive Allosteric Modulators
Jia Zhou, PhD; Haijun Chen, PhD; Kenneth M. Johnson, PhD; Cheng Z. Wang, PhD