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Marburg virus

Negative contrast electron microscopy of infected cell culture and thin section electron microscopy of the liver of an infected nonhuman primate.

  
Marburg neg stn 1967 2

Marburg virus, as seen by negative stain electron microscopy of a diagnostic specimen from the original outbreak in 1967. The virions are still connected to a piece of the plasma membrane of the Vero cell used to grow the virus from a human diagnostic specimen (blood). This image, over the years, came to be called in jest "the duck." Magnification about x70,000.

Micrograph from F. A. Murphy, University of Texas Medical Branch, Galveston, Texas.

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Marburg_virus_in_liver

Marburg virus in the liver of an experimentally infected monkey. Virions bud off the surface membrane of liver cells and accumulate in the narrow spaces between cells. This infection is extremely destructive—shortly after this phase of infection the liver cells are destroyed. The uniformly cylindrical virions are sectioned in various planes—some are seen in longitudinal-section, some in cross-section, some in between. Magnification approximately x40,000.

Micrograph from F. A. Murphy, University of Texas Medical Branch, Galveston, Texas.

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Marburg_virus_in_liver_colorized

Marburg virus in the liver of an experimentally infected monkey -- the same image as above, but colorized. Virions bud off the surface membrane of liver cells and accumulate in the narrow spaces between cells. This infection is extremely destructive—shortly after this phase of infection the liver cells are destroyed. The uniformly cylindrical virions are sectioned in various planes—some are seen in longitudinal-section, some in cross-section, some in between. Magnification approximately x40,000.

Micrograph from F. A. Murphy, University of Texas Medical Branch, Galveston, Texas.

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