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Light microscopic histopathology of the brain of a sheep infected with the scrapie prion.


Scrapie: Lesions in the gray matter of the brain of a sheep with scrapie: (A) typical spongiform change in neurons; (B) spongiform change and astrocytic hypertrophy and hyperplasia. A, hematoxylin and eosin stain; B, glial fibrillar acid protein (GFAP) stain. Magnification x500.

[Micrograph courtesy of Dr. R. Higgins, School of Veterinary Medicine, University of California, Davis]

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