1. Study zoonotic arboviruses in Senegal, Sierra Leone and Nigeria, including identification and characterization of critical reservoir and amplification hosts, enzootic and epidemic vectors, temporal patterns of enzootic and epidemic circulation, levels of human exposure, immune responses and disease outcomes. The emphasis will be on the 4 "urban" (human amplified) arboviruses: CHIKV, DENV, YFV and ZIKV, but other known and possibly unknown viruses will also be studied.
2. In Sierra Leone and Nigeria, study the circulation among enzootic rodent hosts and infections of humans by Lassa virus, including identification of viral determinants of hemorrhagic disease severity and sequelae outcomes.