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Publications/Grants/Projects

Peer-reviewed Publications 

  • Nellis M, Caperton C, Liu K, Tran V, Go Y-M, Hallberg LM, Ameredes BT, Jones DP, Boysen G. Lung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer. Toxicology 463: 152987, 2021
  • Corsello T, Kudlicki AS, Garofalo RP, Casola A. Cigarette smoke condensate changes RNA content of extracellular-vesicles released from small airway epithelial cells. Cells. 3 2019 Dec 17;8(12). doi: 10.3390/cells8121652. PubMed PMID: 31861112; PubMed Central PMCID: PMC6953119.
  • Ivanciuc T, Sbrana E, Casola A, Garofalo RP. 2019. Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke. Pediatric Research. https://doi.org/10.1038/s41390-019-0396-6
  • Litvinov J, Spear W, Patrikeev I, Motamedi M, Ameredes BT. Non-invasive allergic sinus congestion assessment with high-resolution micro-computed tomography imaging. J. Appl. Physiol. 2018 Nov 1;125(5):1563-1575. doi:10.1152/japplphysiol.00980.2017. Epub 2018 Aug 30.
  • Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, Patrikeev I, Ochoa L,Vargas G, Motamedi M, Ameredes BT, Zhou J, Brasier AR. (2018). Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling. Amer J Resp Cell Molec Biol., doi:10.1165/rcmb.2017-04450C. [Epub ahead of print] PMCID: in process
  • Hallberg LM, Ward JB, Wickliffe JK, Ameredes BT. ACES Auxiliary Findings on 2007-compliant Diesel Engines: a Comparison with Diesel Exhaust Genotoxicity Effects Prior to 2007. Environmental Health Insights Volume 11: 1–13, 2017.
  • Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, Macmillion-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in collaborative cross mice. Toxicology 2017 Mar 1;378: 114-124. doi: 10.1016/j.tox.2017.01.005. Epub 2017 Jan 9.
  • Tian B, Patrikeev I, Ochoa L, Vargas G, Belanger KK, Litvinov J, Boldogh I, Ameredes BT, Motamedi M, Brasier AR. NFκB mediates mesenchymal transition, remodeling and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns. Amer J Resp Cell Molec Biol. Apr;56(4):506-520, 2017.
  • James T., Nenov, M., Tapia, C., Koshy, S., Lecchi, M. Green, TA, Laezza F. Consequences of acute Nav1.1 exposure to deltamethrin. Neurotoxicology 2016 Dec 19. pii: S0161-813X(16)30256-X. doi: 10.1016/j.neuro.2016.12.005. [Epub ahead of print]
  • Belanger KK, Ameredes BT, Boldogh I, Aguilera-Aguirre L. The potential role of 8-oxoguanine DNA glycosylase-driven DNA base excision repair in exercise-induced asthma. Mediators of Inflammation 2016; 3762561. Epub 2016 Jul 25.
  • Reno AL, Brooks EB, Ameredes BT. Mechanisms of heightened airway sensitivity and responses to SO2 in asthmatics. Environmental Health Insights. Suppl. 1:13-25, 2015. doi: 10.4137/EHI.S15671 PMCID-PMC4384764.
  • Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK. Part 3. Assessment of genotoxicity and oxidative damage in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay. Res Rep Health Eff Inst. 184:87-105, PMID: 25842617, 2015
  • Sokol K, Sur S, Ameredes BT. Inhaled environmental allergens and toxicants as determinants of the asthma phenotype. Chapter 4 in: Heterogeneity in Asthma: Translational Profiling and Phenotyping, AR Brasier, ed., Advances in Experimental Medicine and Biology, Vol. 795, 43-74, XIV, 354 p. 33 illus., 25 illus. in color; Springer, New York, NY. E-book ISBN 978-1-4614-8603-9; Hardcover ISBN 978-1-4614-8602-2, 2014.
  • Srikanth Kotapati, Dewakar Sangaraju, Amanda Esades, Lance Hallberg, Vernon E. Walker, James A. Swenberg, Natailia Tretyakova; Bis-butandiol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species Carcinogenesis. Jun;35(6):1371-8. doi: 10.1093/carcin/bgu047. Epub 2014 Feb 14., 2014 Carcinogenesis Jun 35(6) 1371-8
  • Barreno RX, Richards JB, Schneider DJ, Cromar KR, Nadas AJ, Hernandez CB, Hallberg LM, Price RE, Hashmi SS, Blackburn MR, Haque IU, Johnston RA. Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholine. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L118-29. doi: 10.1152/ajplung.00080.2013.
  • Ruiz, J, Ameredes, BT. The cellular effects of carbon monoxide in the airway. Curr Mol Med   13(1):94-108, 2013.
  • Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK. Advanced Collaborative Emissions Study (ACES) Subchronic exposure results: biologic responses in rats and mice and assessment of genotoxicity. Part 3. Assessment of genotoxicity and oxidative stress after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: Report on 1- and 3-month exposures in the ACES bioassay. Res Rep Health Eff Inst., (166): 163-184, 2012.
  • Hochman DJ, Collaco CR, Brooks EG. Acrolein induction of oxidative stress and degranulation in mast cells. Environ Toxicol. 2012 Oct 10. doi: 0.1002/tox.21818. [Epub ahead of print] PMID: 23047665
  • Heung M. Lee, Lance M. Hallberg, George H. Greeley, Jr. and Ella W. Englander,. Differential Inhibition of Mitochondrial Respiratory complexes by Inhalation of Combustion Smoke and Carbon Monoxide, Invivo, in Rat Brain, Inhalation Toxicology Aug. 20, 22(9), 770-777, 2010
  • Castro SM, Kolli D, Guerrero-Plata A, Garofalo RP, Casola A. Cigarette smoke condensate enhances respiratory syncytial virus-induced chemokine release by modulating NF-kappa B and interferon regulatory factor activation.Toxicol Sci 2008 Dec,106(2):509-18. doi: 10.1093/toxsci/kfn175. Epub 2008 Aug 22. PMID: 18723827
  • Wickliffe JK, SM Herring, LM Hallberg, LA Galbert, OE Masters III, M M Ammenheuser, J Xie, EC Friedberg, RS Lloyd, SZ Abdel-Rahman, JB Ward, Jr. Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: insights from animal models examining human sensitivity to 1,3-butadiene. Chemico-Biological Interactions, 166, 226-231, 2007.
  • Wickliffe JK, Galbert LA, Ammenheuser MM, Herring SM, Xie J, Masters OE, III, Friedberg EC, Lloyd RS, Ward JB, Jr. 3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice, Environ Mol Mutagen. 67-70, 2006
  • Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB Jr. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1).Toxicol Sci. 2005 May;85(1):624-31. Epub 2005 Feb 16.PMID: 15716486
  • Wickliffe JK, Ammenheuser MM, Salazar JJ, Abdel-Rahman SZ, Hastings-Smith DA, Postlethwait EM, Lloyd RS, Ward JB. A model of sensitivity: 1,3-Butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environ Mol Mutagen. 106-110, 2003.

Grants/Contract Projects/Project and Program Affiliations

  • NIEHS P30 Gulf Coast Center for Precision Environmental Health (GC-CPEH), Strategic Pilot Funding Related to Veterans’ Environmental Health, PIs: Bill T. Ameredes, MS, PhD, and Casey W. Wright, PhD; “Therapeutic Use of SSOs (Splice Switching Oligonucleotides) to Counter Acrolein Toxicity in the Lung,” 09/01/2021 – 08/31/2022.
  • NIH/NIEHS, 1R01ES031823-01A1; PIs: Fernanda Laezza, PhD, and Thomas Green, PhD. “Neurotoxicology of deltamethrin in the developing brain,”09/28/2020 – 09/27/2025.
  • NIH/NIEHS; Chemical Countermeasures Research Program (CCRP) Administrative Supplement to R01ES025809-05S1, PI: Casey W. Wright, PhD; 09/10/2020-05/31/2022.
  • NIH/NIEHS; Chemical Countermeasures Research Program (CCRP) Administrative Supplement to 3T32ES007254-28S1; PI: Bill T. Ameredes, MS, PhD; “Molecular Mechanisms of Environmental Injury”; 08/20/2020-08/31/2022
  • IHII (Institute for Human Infection and Immunity)/UTMB; PIs: Dennis Bente, PhD, Bill T. Ameredes, MS, PhD, Lynn Soong, PhD; “Pilot Funding for Data Acquisition on Coronaviruses and Lung Inflammation Related to Viral Infections,” 04/01/2020 – 8/31/2020.
  • NIEHS P30 Gulf Coast Center for Precision Environmental Health (GC-CPEH), Pilot Grant, PI: Roberto P. Garofalo, MD; “Developmental maturation of the endogenous H2S pathway & susceptibility to second-hand tobacco smoke,” 09/01/2018 – 08/31/2020.
  • NIH/NCATS/CTSA/SCEHM 1UL1TR000071 Novel Methodologies Pilot Grant; PI: Bill T. Ameredes MS, PhD, “CT-Imaging Analysis of Fidarestat Effects on Allergic Rhinitis,” 09/01/2013 – 11/31/2015.
  • Astra/Zeneca, Investigator Initiated Pre-Clinical Research Project, PI: Bill T. Ameredes, MS, PhD; “Effects of Intranasal Roflumilast on Allergic Rhinitis” 11/01/2013 – 12/31/2016.
  • NIEHS/UTMB: Molecular Mechanisms for Environmental Injury (05T32ES007254-20: 1990-2022)
  • NIEHS/UTMB: Cellular Response Mechanisms to Environmental Challenge, Center in Environmental Toxicology (5P30ES006676: 2012-2017)
  • NIEHS/Univ. Arkansas for Medical Sciences: Effects of Genetic Diversity on Cancer Susceptibility. (NIEHS R21ES023046 ; 2014-2016)
  • Alcon Research, Inc.: Effects of Novel Compounds on Nasal Sinus Inflammation (2010-2013)
  • Alcon, Inc., Investigator-Initiated Pre-Clinical Research Project; PI: Bill T. Ameredes, MS, Ph.D.; “Effects of Novel Compounds on Nasal Sinus Inflammation” 01/01/2010 - 05/31/2013.
  • Health Effects Institute: Assessment of Genotoxicity of Diesel Exhaust/Particulates from Improved Diesel Engines. (2010-2013)
  • NIEHS/Univ. North Carolina: Adducts as quantitative markers of butadiene mutagenesis: Inhalation exposure to 1, 3-butadiene. (NIEHS 1R01ES012689 ; 2009-2012)
  • NIEHS/CET/UTMB: Role of IL-10 in SO2-exacerbated Asthma (5P30ES006676: Pilot Project: 2009-2011)
  • Sealy Center for Environmental Health and Medicine (SCEHM)/UTMB
  • Sealy Center for Molecular Medicine (SCMM)/UTMB
  • The Brown Foundation

Abstracts

  •  Luisi J, Motamedi M, Ameredes B. Longitudinal Imaging Reveals Patterns of Neurodegenerative Inflammation in Rotenone-Induced Retinal Neurotoxicity. Toxicol. Letters Volume 331, Supplement 1, 5 October 2020, Page 19, 2020.
  •  Ameredes, BT, Litvinov J, Patrikeev I, Spear WC, Belanger KK, Tian B, Hallberg LM, Motamedi M, Brasier AR. Tissue density-based micro-computed tomography analyses of whole lung remodeling in vivo. Am J. Respir Crit Care Med. (Abstract) Vol. 197: A3906, 2018.
  • Rolls BA, Hallberg LM, Thompson, MA, Prakash YS, Ameredes BT. Effects of cigarette smoke extract and sulfur dioxide on GM-CSF release in human airway smooth muscle cells. The Toxicologist: supplement to Toxicological Sciences, 156 (1): 1926, 2017.
  • Belanger KK, Tian B, Brasier AR, Ameredes BT. Inhibition of IL-6 release in vitro by in vivo administration of an eye KK inhibitor in mice with lung fibrosis induced by poly I: CJ. Allergy Clin. Immunol. Vol. 139, issue 2, 2017.
  • Spear WC, Ballenger KK, Miller SD, Patrikeev I, Motamedi M, Ramana KV, Srivastava SK, Ameredes BT. Fidarestat decreases allergic sinus congestion. J. Allergy. Clin. Immunol. 137 (2), Suppl: AB67, 2016.
  • Hartman JH, Karo AA, Miller GP, Hallberg L, Ameredes BT, Boysen G. The impact of hepatic mitochondrial 72E1 localization in butadiene-exposed mice. The Toxicologist: supplement to Toxicological Sciences, 160 (1), Society of Toxicology, 2016. Abstract number 3155.
  • Rolls BA, Hallberg LM, Thompson MAA, Prakash YS, Ameredes BT. Combined effects of cigarette smoke and S02 on GM-CSF release in human airway smooth muscle cells. The Toxicologist: supplement to Toxicological Sciences, 160 (1), Society of toxicology, 2016. Abstract number 3039.
  • Belanger KK, Spear WC, Rolls BA, Miller SD, Tian B, Vargas G, Motamedi M, Boldogh I, Brasier AR, Ameredes BT. Modulation of IL-6 release subsequent to airway poly I:C administration. J. Allergy Clin.Immunol.137 (2), supplement: AB111, 2016.
  • Ballenger KK, degrees, J, Ameredes BT. Decreases in GM-CSF release and intracellular levels of GM-CSF by human airway smooth muscle cells in response to carbon monoxide and anoxia. J. Allergy Clin.Immunol.135 (2): supplement: AB227, 2015.
  • Spear WC, Patrikeev I, Motamedi M, Ameredes BT. 3-dimensional and 2-dimensional CT-imaging of the sinus airways in a model of allergic sinus congestion. J. Allergy Clin. Immunol. 135 (2): supplemental: AB220, 2015.
  • Spear WC, Miller SD, Ameredes BT. Intranasal roflumilast decreases allergic sinus congestion. Am. J. Resp. Crit. Care Med. Vol. 191: A1374, 2015.
  • Spear WC, Reno, AL, Patrikeev I, Motamedi M, Ameredes BT. A novel, spleen, tyrosine kinase inhibitor (and S YK-I) decreases allergic sinus congestion. Am. J. Resp. Crit. Care Med. Vol. 189: A5654, 2014.
  • Rolls BA, Aguilera-Aguirre L, Hallberg LM, Boldogh I, Halayko AJ, Ameredes BT. Comparison of intracellular mRNA modulation and GM-CSF release in donor-matched hTERT immortalized and primary human airway smooth muscle cells. Am. J. Resp. Crit. Care Med. Vol. 189: A5315, 2014.
  • Rolls BA, Aguilera-Aguirre L, Hallberg LM, Boldogh I, Halayko AJ, Ameredes BT. Carbon monoxide modulation of mRNA in human airway smooth muscle cells. The Toxicologist Vol. 138, 1: 921, 2014.
  • Bemis J, Hallberg LM, Conklin DJ, Kong M, Ameredes BT, Ward JB, Hernandez C, Zaas S, Norton C, Wickliffe J. Effects of diesel exhaust on markers of genetic and cardiovascular toxicity in rats: results from the ACE S study, annual meeting Society of Toxicology, Phoenix, Arizona, the Toxicologist, 138, (1), 127, March 2014.
  • Aguilera-Aguirre L, Bocsi A, Wood TG, Brasier AR, Ameredes BT, by X, Boldogh I. Oxidative DNA damage/repair induces inflammatory gene expression in the airways of 8-oxoguanine DNA glycosylase-mediated cell signaling. Toxicologist Vol. 138, 1: 238, 2014.
  • Hallberg LM, Parks JL, Hernandez CL, Norton CM, Ward JB, Ameredes BT, Wickliffe JK. Biomarker-based Evaluation of Diesel Exhaust Emissions from 2007-Compliant Engines in Rats and Mice Exposed for Defined Time Periods. Society of Toxicology Annual Meeting San Antonio, Texas, Toxicologist 132(1) 399, 2013.
  • Hallberg LM, Parks J, Hernandez C, Ward JB, Ameredes BT, Norton C, Zaas S, and Wickliffe JK. ACES: Genotoxicity of Diesel Exhaust from 2007-Compliant Diesel Engines: A Continuation of the Study, Health Effects Institute Annual Meeting San Francisco, California 32, 2013.
  • Reno AL, Hallberg LM, Spear WC, Parks JL, Chaparro AP, Brooks EG, Ameredes BT. Sulfur dioxide modulates oxidative stress responses in IL-10 deficient mice with airway inflammation. Society of Toxicology Annual Meeting San Antonio, Texas, Toxicologist 132(1) 431, 2013.
  • Hallberg LM, Ward JB, Ameredes BT, Wickliffe JK. Assessment of the Genotoxicity of Diesel Exhaust Particulates from Improved Diesel Engines. Health Effects Institute Annual Meeting Chicago, Illinois 36, 2012.
  • Reno AL, Hallberg LM, Spear WC, Parks JL, Principe MF, Brooks EG, Ameredes BT. Sulfur dioxide promotes a pro-oxidant shift in IL-10-deficient mice with airway inflammation. The Toxicologist Vol. 126 (1), 2012.
  • Ruiz J, Hallberg LM, Panettieri, Jr. RA, Ameredes BT. Involvement of the mitochondrial respiratory chain in the anti-inflammatory effects of carbon monoxide in human airway smooth muscle cells. Am. J. Resp. Crit. Care Med. Vol. 185: A1277, 2012.
  • Hallberg LM, Parks JL, Hernandez CL, Norton CM, Ward JB, Ameredes BT, Wickliffe JK. Genotoxicity of diesel exhaust from 2007-compliant diesel engines: a continuation of the ACES study Health Effects Institute Annual Meeting Boston, Massachusetts, 2011.
  • Ruiz J, Hallberg LM, Parks JL, Panettieri RA, Boldogh I, Ameredes BT. Reduction of intracellular ROS levels and oxidative metabolic activity in human airway smooth muscle cells by carbon monoxide and hypoxia. Am. J. Resp. Crit. Care Med. Vol. 183: A2538, 2011.
  • Reno AL, Hallberg LM, Parks JL, Calhoun WJ, Ameredes BT. Modulatory effects of sulfur dioxide on the production of nitric oxide in murine airway inflammation. Am. J. Resp. Crit. Care Med. Vol. 183: A1423, 2011.
  • Ruiz, J, Duru EA, Parks JL, Panettieri RA, Calhoun WJ, Ameredes BT. Reduction of GM-CSF release in human airway smooth muscle cells by carbon monoxide, hypoxia, and anoxia. Am J Respir Crit Care Med Vol. 181:A3597, 2010.
  • Thompson M, Shilpi G, LM Hallberg, JB Ward, JA Swenberg, G Boysen. Effects of styrene co-exposure on formation of 1,3-butadiene derived N7-guanine adducts. Society of Toxicology Annual Meeting Salt Lake City, Utah, Toxicologist 114(1) 400, 2010.
  • Reno AL, Duru EA, Parks IV JL, Aloi FP, Choi AMK, Calhoun WJ, Ameredes BT. IL-12p40 subunit expression in lungs of mice administered low-dose carbon monoxide. Am. J. Resp. Crit. Care Med. 179: A5448, 2009.
  • Ruiz J, Duru EA, Parks IV JL., Panetierri RA, Calhoun AJ, Ameredes BT. Reduction of GM-CSF release in human airway smooth muscle cells by carbon monoxide and hypoxia. Am. J. Resp. Crit. Care Med. 179: A3170, 2009.