Obstetric-Fetal Pharmacology Research Centers

OPRU Protocols

• Pravastatin for the Prevention of Preeclampsia in High-Risk Women: A Phase I Pilot Study
• Glyburide and Metformin for Gestational Diabetes Mellitus: A Phase I-II Randomized Trial
• Determining the Pharmacodynamic Impact of Vaginal and 1M Progestins on the Cervix
• Pharmacokinetics of Understudied Drugs Used During Pregnancy (Opportunistic)
• Pharmacokinetics and Pharmacodynamics of Glyburide in Gestational Diabetics and Type 2 Diabetics (Glyburide)
• A Study of the Pharmacology of 17-Hydrozyprogesterone Caproate in Pregnancy (Caproate)
• Levothyroxine Pharmacokinetics Based on State-of-the-Art Analytic Methods (Levothyroxine)
• A Double-Blind Multicenter Randomized Placebo Controlled Trial of the Efficacy of Diclectin® for Nausea and Vomiting of Pregnancy
• Clonidine Hemodynamic Effects during Pregnancy
• Effects of Pregnancy on Metformin Pharmacokinetics
• Human Placental Transfer of Metformin and Rosiglitazone
• Human Placental Transfer of Glyburide
• Placental Biotransformation of Glyburide during Pregnancy: Implications for Identification of the Enzymes and Metabolites
• Placental Transfer and Biotransformation of 17-Hydroxyprogestrone Caproate
• Bcrp1/ABCG2 and Fetal Distribution of Glyburide
• Effects of Pregnancy on Clonidine Pharmacokinetics
• Dacarbazine and the Effects of Pregnancy on CYP1A2
• Cyclosporine and Placental P-glycoprotein Activity
• 17-OHPC Basic Science Studies
• Gestational-Age-Dependent Changes in Placental P-glycoprotein Activity in the non-human primate, Macaca nemestrina
• Pharmacokinetics of Oseltamivir among Pregnant and Nonpregnant Women
• Impact of Glucocorticoid Polymorphisms on Markers of Neonatal Respiratory Disease after Antenatal Betamethasone Administration
• Duration of Cisplatin Excretion in Breast Milk
• Tacrolimus Concentrations during Pregnancy and Postpartum
• Transplacental Transfer of Vancomycin and Televancin