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Twenty-five Methodological Approaches Used to Answer Questions in Pharmacology & Toxicology at UTMB
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Chromatin immunoprecipitation, genome-wide 'omics' technologies, CRISPR/Cas9 gene editing, gene x environment interactions.
Primary neuronal and brain slice cultures and live cell analysis of cell signaling pathways
De novo synthesis of drug-like small molecules for development of chemical probes and therapeutics in cancer and brain diseases
Cellular and molecular live cell screening of novel chemical entities for drug discovery
Preparation of pancreatic islet cells for study of pancreatic cancer
Tissue specific (conditional) knockout mouse models
Silver, TUNEL, caspase-3 measurements as indices of neuronal death
Quantitative immunohistochemistry and immunocytochemistry and Western analyses of disease and cell type markers (including Simple Wes)
40+ preclinical rodent models based on behavior, genetics and physiology, geared to uncover disease-modifying genes, therapeutic targets, mechanistic hypotheses, and in vivo drug discovery screens
Design and employment of viral gene transfer approaches for RNAi mediated knockdown or over expression of genes of interest into specific brain regions and study of subsequent behaviors
C/MS determination of pharmacokinetic identification of placental enzymes responsible for the biotransformation of medications during gestation
Mechanism of action of human placental transporters and genomic SNPs that affect transfer of medication during pregnancy
Use of nanoparticles for drug delivery
Novel therapeutic approaches for prostate cancer using adipose stem cells and ultrasound-mediated gene delivery with molecular imaging to assess therapy efficacy and tumor growth in vivo
Neuronal ion channel pharmacology and physiology; molecular mechanisms of synaptic plasticity & neuronal excitability
Protein: protein interaction as a basis for GPCR drug discovery
Methodological development to determine the concentrations of drug metabolites in fluids from pregnant patients in order to characterize drug metabolism and pharmacokinetics in the pregnant patient
In vitro identification and characterization of kinetic parameters of placental metabolic enzyme(s) responsible for the biotransformation of medications in term and preterm trophoblast homogenates, vesicle preparations and cytosolic fractions
Synthesis and loading of placenta-targeted nanoparticles with medications for fetal treatment during pregnancy
Primary neuronal, brain slice culture and in vivo analysis of cell signaling pathways by western/northern analysis
Behavioral assessment of locomotor activity, anxiety, pre-pulse inhibition of acoustic startle, social discrimination and feeding behavior
DNA microarray, chromatin immunoprecipitation, mass spectrometry in regulation of transcription.
Intravenous self-administration of drugs of abuse or palatable food rewards by rats behaving under operant conditions
Measurement of intracellular calcium concentration as a function of disease state and/or drug effect
Employment of viral gene transfer approaches for RNAi mediated knockdown or overexpression of genes of interest in specific regions and study of specific behaviors