Welcome to the Bonifazi LabReceptor Chemistry Unit
The Bonifazi Lab is a highly translational and interdisciplinary medicinal chemistry and drug discovery research group applying and combining techniques and methodologies from synthetic organic chemistry to in vitro cellular and molecular pharmacology.
"Doubt is the Beginning of Wisdom" - Rene Descartes
Mission
Our mission is to advance neuroscience and neurotherapeutics by designing, synthesizing, and developing small molecules that serve as pharmacological tools and potential treatments for neuropsychiatric disorders. We are committed to deepening the understanding of G protein-coupled receptor (GPCR) (patho)physiology and leveraging this knowledge to drive impactful discoveries in brain science and health.
Research Interests and Scientific Approach
Research Interests and Scientific Approach
We aim to create novel ligands that facilitate the understanding of cross-pharmacological modulation in receptors. Additionally, we investigate receptors’ pathway activations at the molecular level, elucidating their roles in the (patho)physiology of the central nervous system (CNS). We strive to provide molecules to study GPCR-ligand complexes formation, signaling mechanisms and cellular functions, aiming to understand the foundational insights necessary for safer therapeutic drug development. We combine advanced organic chemistry methodologies and in vitro cell-/tissue-based radioligand b inding assays to synthesize, characterize and screen new compounds to generate structure-activity relationships (SAR).
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We are committed to expanding our network of national and international collaborators to implement in silico models, molecular pharmacology, ex vivo and in vivo animal models to characterize and fine-tune the desired pharmacological profile of the new ligands for the treatment of neuropsychiatric disorders. Potential therapeutic applications for study: - Sleep disorders in neuropsychiatric conditions
- High-Impulsivity behaviors
- Feeding disorders
- Substance use disorders
- Locomotor disorders
- Pain
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We believe in a multi-disciplinary approach and that collaborations are the cornerstone of scientific progression and innovation. |