Matthew T. Weirauch, PhDAssociate Professor, UC Department of Pediatrics, The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, USA

Matthew Weirauch is currently an Associate Professor in the UC Department of Pediatrics and The Center for Autoimmune Genomics and Etiology (CAGE) at the Cincinnati Children’s Hospital Medical Center. He is a bioinformatician geneticist who works to achieve a thorough understanding of human and viral transcriptional regulation mechanisms in complex diseases. Since joining Cincinnati Children’s in 2012, he has helped develop new computational tools and experimental data to attain a mechanistic understanding of gene regulation.

His lab is highly collaborative; He and his colleagues work on a wide range of biological and disease topics. They also take a general approach of using all available data to generate and ultimately validate new hypotheses. They’ve long been interested in gene regulation because it’s a fundamental process underlying all life. It’s the first step in translating the “instructions” that are encoded in DNA into various functions. More recently, they’ve expanded our focus to include the role of viruses in human gene regulation and how this contributes to human disease processes.

He and his colleagues discovered (and continue to study) a critical role for the Epstein-Barr virus EBNA2 protein in the mechanistic processes underlying several autoimmune diseases. They are currently examining how the hundreds of regulatory proteins encoded by other viruses contribute to other human diseases. They’ve also constructed several widely used databases that summarize current knowledge about all eukaryotic and viral gene regulatory proteins.

Email: matthew.weirauch@cchmc.org
Phone: (513)803-9078
Link: https://www.cincinnatichildrens.org/bio/w/matthew-weirauch