Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

Altitude Gene, A Denisovan Gift

MP3 WAV

  • If you traveled to Tibet, called the roof of the world, you'd have a tough time catching your breath because the average altitude there is thirteen thousand feet! But Tibetans thrive there! It turns out they're the only modern humans to possess a gene they may have inherited from a now extinct species of ancient human called Denisovans.

    When we look at another group of people living at high altitude, in the Andes Mountains of South America, they produce higher levels of hemoglobin in their blood. They also have larger chests that accommodate larger lungs, but Tibetans don't exhibit these physiological adaptations.

    Recent studies reveal Tibetans possess a unique form of the EXPAS1 gene. In others, this gene responds to low oxygen levels by increasing hemoglobin production. But the opposite happens in Tibetans. They do not have elevated levels of hemoglobin. This is counterintuitive since in theory, increasing hemoglobin increases oxygen transport in the blood which helps in high altitude where the air is thinner. But it's also true that too many blood cells thickens the blood, and increases stroke risks. So, scientists are unsure exactly how this Tibetan variant of the EXPAS1 gene protects them.

    The newest study tells us this gene may have come from an extinct species of humans. The Denisovans' fossils were only discovered four years ago in Southern Siberia. But the Neanderthals also have a similar version of the EXPAS1 gene, so the source is unclear. What's fascinating is that modern humans may owe some of their beneficial traits to ancestors who interbred with ancient humans that helped them to survive and spread across the planet.

More Information

Tibetan altitude gene came from extinct human species

Altitude Effects on the Human Body

Denisovans
"Denisovans, together with Neanderthals, are our closest extinct relatives. They are a recently discovered group of ancient humans from whom only a few fossil fragments, dated to about 40,000 years ago, have been found."

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

See all podcasts and radio stations

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.