Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

Cancer Detection in a Breath

MP3 WAV

  • Once someone has had cancer, they have one fear: that it may come back. That fear is heightened for people with deadly tumors, such as lung cancer, the leading cause of cancer deaths in every ethnic group. These patients follow up with regular CT scans to look for tumors, but a new test under study would need just the person's breath.

    The breath test looks for volatile organic compounds or VOCs, of which there are thousands in the exhaled breath. Scientists have discovered that the type of VOCs in the breath of lung cancer patients are a subset of chemicals called carbonyls.

    All a patient would have to do is blow about one liter of air into a special balloon that's attached to a pump. The pump moves the air over a microchip that traps the VOCs from the breath. A machine called a mass spectrometer reads the chip, identifying and quantifying the compounds.

    In the current study, the breath of 31 lung cancer patients were compared with healthy people before and after their tumors had been surgically removed. Indeed, post-surgery, the cancer patients had lower levels of four VOCs associated with lung cancer in their breath. And three out of the four VOCs were at levels comparable to healthy people, so for now the new test does seem accurate.

    The study was pretty small, so one involving many more patients' breaths will have to be analyzed to confirm its effectiveness in diagnosing the recurrence of lung cancer. If successful, the test would be superior to the low-dose helical CT scan now being used which has a high false positive rate. You can imagine the emotional and financial strain of a false positive result.

    So, at just 20 bucks, and a few hours, the breath test would be a healthier, easier, and possibly more accurate option.

More Information

Lung cancer breath 'signature' presents promise for earlier diagnosis
Being able to identify lung cancer "signature" through a simple breath test has emerged as one of the most promising ways to diagnose the disease. Now the test is being used to monitor for disease recurrence.

Normalization of Exhaled Carbonyl Compounds After Lung Cancer Resection
Presented at the Fifty-second Annual Meeting of The Society of Thoracic Surgeons, Phoenix, AZ, Jan 23'27, 2016.

SEER Stat Fact Sheets: Lung and Bronchus Cancer
From the National Cancer Institute of the National Institutes of Health

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.