Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

Dire Wolves: Not a Wolf at All

MP3 WAV

  • If you're a fan of the popular HBO series Game of Thrones, you may have wondered whether the dire wolf is a real breed of wolves. They were likeable characters because they were fiercely loyal to their owners, the Stark family children.

    The truth is dire wolves are real and roamed the Earth from two million to eleven thousand years ago during the Pleistocene Epoch. Many of their skeletal remains have been found in the La Brea Tar Pits in southern California, as well as Ohio, Florida, and Mexico. The latest genetic studies revealed that dire wolves overlapped with early humans in North America and that they may have died out with the wooly mammoths at the end of the last ice age.

    What's also surprising is to learn that they're only distantly related to wolves. Yes, they share many features but dire wolves are larger than today's gray wolf weighing one hundred fifty pounds. They had much bigger skulls but smaller brains and likely had reddish coats. Based on this genomic research, dire wolves will have a separate phylogenetic classification, termed Aenocyon dirus. Aenocyan translates as "terrible" for it being a fierce predator of large herbivores. They didn't interbreed with wolves or other dog-like species.

    This isolation of its gene pool, extinction of its prey caused by climate change, and competition from smaller wolves all led to the dire wolf's demise. Now we just need science to tell us what happened to the dragons!

More Information

The legendary dire wolf may not have been a wolf at all
One of North America's most famous ancient predators-and a favorite of Game of Thrones fans-emerged as mysteriously as it disappeared. Dire wolves, which died out with mammoths and saber-toothed cats at the end of the last ice age, were long thought to be close cousins of gray wolves. Now, the first analysis of dire wolf DNA finds they instead traveled a lonely evolutionary path: They are so different from other wolves, coyotes, and dogs that they don't belong in the genus that includes these animals. Instead, researchers argue, they need an entirely new scientific classification...

Dire wolves were real-and even stranger than we thought
A study of extinct dire wolf DNA reveals surprises, including that the carnivores, made famous as fictional pets in Game of Thrones, weren't closely related to wolves...

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.