Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

Reversing Blindness with Stem Cell Therapy

MP3 WAV

  • Imagine an accident at work leaves you blind for sixty years. And now a new medical procedure gives you your sight back.

    You'd probably feel like you'd been given a miracle.

    It not quite a miracle but it is fascinating research. Scientists in Italy found a way to reverse blindness in people whose corneas were damaged by chemical burns.

    The cornea is the clear layer on the surface of the eye.

    Although artificial and donated corneas are treatment options, both can involve complications. Another option being tried involves stem cells.

    In our corneas is an area called limbus, which contains stem cells that continue to replace dead corneal cells.

    When chemical burns destroy our limbus, stem cells also die. That means corneal cells are not replaced and scar tissue begins to form, impairing the person's eyesight.

    There have been attempts to transplant limbus tissue from the healthy eye to the scarred eye, but half the limbus would have to be transplanted to ensure enough stem cells are present to generate new corneal cells.

    However, making a mistake while trying to remove such a large area of limbus tissue would risk losing sight in the healthy eye.

    Except, the Italian researchers used bioengineering to get around this. They took just a small number of stem cells from an undamaged area of the eye to grow in the lab. They grew new cells in a sheet, then transplanted it over the area where the scarred cornea was removed so it could begin generating new corneal cells.

    Of the one hundred twenty one patients who were treated, an astounding eighty-two (or two-thirds of the patients) got their sight back. Fourteen had partial restoration.

    The procedure is possible even when both eyes are damaged, as long as there is enough limbal tissue to collect stem cells to expand in the laboratory. This is the ultimate in fix it yourself.

More Information

Limbal Stem-Cell Therapy and Long Term Corneal Regeneration.
New England Journal of Medicine 2010, (10.1056/NEJMoa0905955)
Original journal article by the Italian research group reporting on the results of their stem cell transplants procedure.

Stem cells reverse blindness caused by burns. (Alicia Chang - AP Science writer) Bioscience Technology June 23, 2010.
Review of limbal cell therapy highlighting the results of the Italian research reported in the NEJM.

Stem Cell Basics
Excellent background form the National Institutes of Health website. "This primer on stem cells is intended for anyone who wishes to learn more about the biological properties of stem cells, the important questions about stem cells that are the focus of scientific research, and the potential use of stem cells in research and in treating disease. The primer includes information about stem cells derived from embryonic and non-embryonic tissues."
For more information...

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.