Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

Reviving Hair Cells and Hearing

MP3 WAV

  • More and more of us either have or will have hearing problems. In fact the number of Americans with hearing loss has nearly tripled in the last forty years to 36 million.

    Now, gene therapy to the rescue. In this case a gene called Math1 has been used to generate new hair cells inside a guinea pig's inner ear known as the cochlea. For us, those tiny hairs pick up sound vibrations to allow us to hear.

    One reason why more Americans are facing hearing loss is prolonged exposure to loud noises. I hate to sound like an old guy but loud music is usually the problem.

    People are blasting music in their cars and iPods which over time wears out the tiny hairs in the cochlea that pick up sound vibrations.

    This type of hearing loss is called sensorineural which is damage to the cochlea or to the nerve pathways from the inner ear to the brain. The result is a reduction in sound level and difficulty hearing faint sounds. But a person can also have trouble understanding speech.

    The goal of this latest study is to reverse the damage by growing new hairs using the Math 1 gene. Scientists did this with guinea pigs that had hearing loss.

    They genetically modified the hair cells to make more of the math one protein.

    Sure enough, the modified hair cells made more of it. And even though the higher protein levels were temporary, new hairs cells grew to replace those that were damaged and they were permanent.

    The catch is you'd have to treat the ear within ten days of the damage. So the challenge now is to figure out how to grow the hair cells long after the damage was done.

    Until then... we'd suggest turning down the volume and spending less time blasting your ears.

More Information

For the original scientific article describing that nonsensory cells in the mature cochlea retain the competence to generate new hair cells after overexpression of Math1 in vivo and that Math1 is necessary and sufficient to direct hair cell differentiation in these mature nonsensory cells.

For a very nice summary of the study using the Math1 gene to regrow hair cells, go here.

For more information about the ear and other study results toward the restoration of hearing go here.

To learn more about how the ear actually works with wonderful illustrations go here.

For an explanation that your kids can understand and appreciate go here. There are also links to additional information including the effect of loud music or wearing an MP3 player all the time on the ears.

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.