Recent Episodes
Norbert: Dave, pass me the nanosponges, I've got to clean up toxins in my blood!
Dave: They're not really tiny sponges, are they?
Norbert: No, but they act like tiny sponges by trapping toxins that damage healthy cells.
Nanosponges are ninety times smaller than our red blood cell, but they can absorb between thirty and nine hundred cell-damaging toxin molecules.
Imagine these nanosponges flooding your body when you're infected by bacteria such as Streptococcus and Staphylococcus, families of bacteria that includes MRSA, which is deadly.
These two pathogens can be resistant to many antibiotics, and they produce pore-forming toxins. These toxins insert themselves in the cell membrane creating holes that end up killing the cell, including red blood cells.
But in a study with mice, remarkably, 90% of mice treated with the nanosponges before a MRSA infection survived. Even if the nanosponges were given after a MRSA infection, 44% of mice still survived.
The nanosponges are made out of a polymer, the same biodegradable material used in some implants. Then they're covered with pieces of red blood cell membrane to cloak them from the immune system - otherwise they'd be immediately removed by white blood cells.
Toxins that come into contact with pieces of red blood cell membrane attach to the nanosponges, form pores, and are trapped by the core polymer. Eventually they're eliminated by the liver.
The strength of this therapy is that it works on a number of toxins compared with other treatments which only target one specific toxin. This technology is promising because it has the potential to be used in other treatments, even in delivering cancer-killing drugs.
Medicine...
Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.
Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.
No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.
Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.