Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

The World's Smallest Factories

MP3 WAV

  • I remember an exciting moment in the '70s when scientists began developing synthetic biology. We could all see the potential of the technology, which is the deliberate modification of simple organisms such as yeast, to make medicines or other molecules that have commercial value.

    For example, we no longer need to harvest the bark of willow trees to produce aspirin because we've moved the genes involved in its biochemical pathway into yeast. A series of chemical reactions, catalyzed by proteins called enzymes, produce the drug. Other chemical pathways are present in all plants and organisms, which we've been able to exploit to make various products in the lab using yeast.

    Now we may have successfully done the same with morphine. This could create a reliable supply without cultivating the poppy crop which has long had political and criminal impacts since heroin is produced from morphine. It would also eclipse legitimate farmers who produce morphine for prescription drug use since yeast factories are not subject to weather.

    On the flip side, if criminals got access to the technology, they'd also have an easier way to produce heroin and maybe create an even cheaper illegal supply of the addictive drug. Obviously, we'd need to guard the technology.

    The advantage of yeast is that you can grow billions of these engineered organisms in the lab and then extract the drug that was made. No harvesting of plants or extensive chemical synthesis is needed. It is really that easy. Today, the most effective malaria drug is produced this way and even Vanillin' the synthetic vanilla that flavors some of your favorite foods.

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.