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Venom for Stroke

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  • You may not want to squish every spider you see when you hear today's episode. We're talking about the deadly Australian funnel spider whose venom can do the incredible job of reducing the brain damage caused by stroke. Both of the two types of funnel spiders are on the list of the most deadly spiders. The male venom is five times more toxic than the female's due to something called Robustoxin. Thirteen people have died fifteen minutes after these spider bites.

    The area immediately affected by the stroke is irreversibly damaged, but cell death in the region around that takes hours and even days to happen, so this is where the toxin can help. When blood supply to the brain is disrupted, the cells continue to use glucose. But without the presence of oxygen, acid is produced which is what kills brain cells. Something in the brain called the Acid-Sensing Channel one-a is the primary cause for acid induced brain cell damage.

    As it turns out, something in the funnel spider venom completely blocks this channel: Australian researchers identified it as a small protein component called H-i-one-a. Giving this protein component to patients may stabilize that primary acid sensing channel so that it does not conduct its signal in response to increasing acid level.

    Just a small dose of it two hours after a stroke prevented eighty percent of stroke damage in rats. Given even after eight hours averted sixty five percent of damage. This is just one of many therapies scientists have been able to source from venoms, and it's a growing area of research. Yet another reason to thank our animal allies.

More Information

Funnel-Web Spider
Funnel-web spiders, the most notorious members of our spider fauna, are found in eastern Australia. There are at least 40 species of funnel-web spiders...

Venom from the funnel web spider could prevent brain damage from strokes after 'world-first discovery'
Venom from the deadly funnel web spider can be used to protect the brain from devastating stroke damage, scientists have found...

Funnel-Web Spiders: Families, Bites & Other Facts
unnel-web spiders are spiders that build funnel-shaped webs, which they use as burrows or to trap prey. Three distinct spider families are known popularly as funnel-web spiders, but they are all quite different.....

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
Six million people die each year from stroke, and 5 million survivors are left with a permanent disability...

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