Medical Discovery NewsBridging the World of Medical Discovery and You

Recent Episodes

We Need Jumpin' Genes

MP3 WAV

  • The DNA in the nucleus of our cells is inherited from our parents, so if we compared the structure of our DNA with our parents, they'd be the same, right? Well, they're not.

    One reason is our jumping genes which are also called transposons. They're pieces of genetic information that randomly move about the genome. It's not a problem unless one inserts itself into an important gene and causes cancer.

    One jumping gene is called LINE-one, or Long Interspersed Nuclear Element One and represents nearly a fifth of the DNA in every cell. Up until recently they were considered 'junk DNA'.

    Given that so many copies of LINE-one have been retained in the human genome throughout evolution, it does not make sense that it is merely junk DNA. A post-doctoral fellow decided to study how LINE-one affects embryonic development which scientists had already known causes Line-One to be highly active.

    The researcher devised a way to turn off LINE-one in mouse embryos. This caused the embryo to stop at the two-cell stage which is immediately after a fertilized egg splits the first time. However, when LINE-one was turned back on but not allowed to jump, there was no effect on embryo development.

    This means, LINE-one plays an important role in the developing embryo but its ability to move about the genome has nothing to do with that role. Perhaps it serves as 'molecular glue' to bring together molecules that turn off portions of the genome at the two-cell stage to allow other genes to further embryo development.

    We don't know yet if LINE-one has the same functions in humans. What is clear is that it's not junk DNA.

More Information

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity
Transposable elements represent nearly half of mammalian genomes and are generally described as parasites, or 'junk DNA.' The LINE1 retrotransposon is the most abundant class and is thought to be deleterious for cells, yet it is paradoxically highly expressed during early development. Here, we report that LINE1 plays essential roles in mouse embryonic stem cells (ESCs) and pre-implantation embryos...

A lncRNA-like Role for LINE1s in Development
Transposable elements (TEs) have profoundly affected the evolution of transcriptional and chromatin profiles in mammalian genomes. In a recent paper, Percharde et al. (2018) identify a lncRNA-like function for LINE1 transposable elements in regulating gene expression to facilitate embryonic stem cell self-renewal and preimplantation development...

Two individuals wearing headphones stand in a recording booth, speaking into microphones with a music stand holding printed pages between them.

 Medicine...

Medicine is constantly advancing – that is a great thing about life in the 21st century. But it doesn’t just happen. Dedicated biomedical scientists are making discoveries that translate into those new medical advances.

Biomedical science is broad, encompassing everything from social science to microbiology, biochemistry, epidemiology, to structural biology and bioinformatics to name just a few areas. And, it can involve basic fundamental biology, the use of AI and chemistry to clinical studies that evaluate new medicines in patients.

No matter the research focus, the goal is always the same, to advance human health. It may take a few months, a few years or for fundamental science, a few decades. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today on the medicine of tomorrow. Our weekly 500-word newspaper columns and 2-minute radio shows and podcasts provide insights into a broad range of biomedical science topics.

Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine.

Podcasts

Alternatively, you can copy and paste the following web address (URL) into iTunes as a new subscription:
https://www.medicaldiscoverynews.com/shows/audio/mdnews.rss

You can also search and subscribe to "Medical Discovery News" in the podcast section of iTunes.

The www.medicaldiscoverynews.com web site and Medical Discovery News radio program (Program) are made possible by The University of Texas Medical Branch at Galveston (UTMB)as a community service and are intended to advance UTMB's mission of providing scholarly teaching, innovative scientific investigation, and state-of-the-art patient care in a learning environment to better the health of society and its commitment to the discovery of new innovative biomedical and health services knowledge leading to increasingly effective and accessible health care for the citizens of Texas.

All information provided on the web site and in the Program is for informational purposes only and is not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. Any information obtained by participating as a web site visitor or program listener is not intended to and should not be considered to constitute medical advice.

Thoughts and opinions expressed on the Program or on the website are those of the authors or guests and do not necessarily reflect the opinions of UTMB. The provision of links to other websites is not to be construed as written or implied sponsorship or endorsement of such websites by UTMB.

Please contact Dr. David Niesel or Dr. Norbert Herzog via email with any concerns, suggestions or comments.

All rights are reserved to information provided on the website or other information sources. No part of these programs can be reproduced stored in a retrieval system or transcribed in any form or by any means for personal or financial gained without the express written permission of Drs. Niesel and Dr. Herzog.