Drs. Amina Ayadi, Steven Wolf, Nisha Garg, and Juquan Song, with collaboration from Sophia Lee and Allison Wyrick, had their abstract titled “Enhanced Burn Wound Healing and Conversion Prevention Through Inhibition of High Mobility Group Box 1 in a Scald Burn Rat Model” published in the American Burn Association’s Journal of Burn Care & Research.

Their study investigates the effects of anti-HMGB1 antibody treatment on wound progression in a rat model of scald burns. Severe burn injuries are known to trigger intense hyperinflammatory and hypermetabolic responses, which can lead to systemic organ damage. HMGB1, an inflammatory mediator released from damaged tissues, plays a key role in these processes. The findings contribute to a deeper understanding of potential therapeutic approaches for improving burn wound healing and preventing wound conversion.