Spring Terms Courses and Descriptions

Lab Rotation Report Form
Syllabus
This is a required core course in the Basic Biomedical Science Curriculum (BBSC). Students in the BBSC are required to take three 8-week rotations in a minimum of two independent laboratories during their first year in the BBSC. The first two rotations must be performed in different laboratories. The third rotation should only be performed with a previous rotation mentor if there is a commitment that the student will be joining the lab and therefore does not need to rotate with a third faculty mentor; otherwise the student should perform all rotations with different mentors. Mentor expectations and grading criteria and student course schedules should be communicated between the mentor and student at the start of the rotation. The time commitment is at least 6-18 hours/week in the lab, but will vary. Students should respect the timing of experimental protocols and usual lab procedures and schedules. Faculty should appreciate the demands of class attendance and coursework on students; there should be a reasonable amount of flexibility in apportioning the working hours during a week or even among weeks. If it is necessary for the student to work outside of a typical work week or typical work-day hours, this should be clearly communicated to the student when the rotation is initially arranged. Students will be required to submit a written report that includes a description of the research, experiments attempted, interpretations, accomplishments, etc., along with a Student Evaluation Report form completed by the faculty member.

Prerequisites: None
Term offered: I, II, III with no more than six credit hours (16 weeks) in one lab
Year offered: Annually
Hours per week: 6-8 hours/week in the lab
Instructor: Toliver-Kinsky

Teaching in Biostatistics (BBSC 6128)

Syllabus
In this course, students will learn and practice skills necessary to facilitate students participating in biostatistics labs. Facilitator Skills Workshops will be imparted by personnel from the School of Medicine Office of Educational Development. At the end of the course, students will: (a) Be able to distinguish between actual content (the concept the small group is working on) and process (how the group works on acquiring and developing knowledge on that concept); (b) Understand the various group member roles related to both content and process; (c) Have practiced methods for effective communication; (d) Have learned effective questioning skills; (e) Have practiced effective listening skills and empathy; (f) Be capable of providing effective feedback; (g) Be capable of maintaining engaging group discussions and (h) Be able to provide constructive evaluations. Students will serve as lead facilitators for the lab component of students enrolled in BBSC 6222 (Biostatistics), where they will implement and develop their facilitation skills. Prior to each session with the BBSC 6222 students, small group facilitators will be provided with fully answered laboratory solutions and will have an opportunity to discuss these computer labs with course instructors. Each facilitator will provide formative and summative evaluations of those BBSC 6222 students in their lab sessions. This course is offered on a Satisfactory/Unsatisfactory basis. A grade of satisfactory will be dependent on: (a) attendance of the student to all scheduled course sessions and instructor discussions (as detailed above); (b) writing a one-page reflective piece that will serve as self-evaluation; (c) acceptable performance as facilitator as judged by the course instructor, after consulting with the students being facilitated.

Prerequisites: BBSC 6222 or any of the Biostatistics classes from the PHS Biostatistics Track (PHS/BIOS 6343 Biostatistics, PHS/BIOS 6347 Applied Statistical Methods
Term offered: II
Year offered: Annually
Hours per week: Laboratory 2
Instructor: Chakraborty

Responsible Conduct in Biomedical Research (BBSC 6129)

Syllabus
This course will cover all topics recommended by NIH for required instruction in responsible conduct of research (RCR), described in NOT-OD-10-019, and will incorporate contemporary ethical and regulatory issues in modern biomedical research. The course will begin in the Fall term and will extend over all 3 terms of the academic year. Students will register for the course in the Fall term and will be automatically enrolled the following Spring and Summer terms. A grade of "G" (longitudinal) will be assigned at the end of the Fall and Spring terms, and a single, 1-hour course grade will be assigned at the end of the Summer term. Specific RCR topics covered in a given term will be temporally aligned with relevant science or research topics being taught in the Basic Biomedical Sciences Curriculum courses during that term. Small group sessions and case studies will be utilized to discuss and integrate designated RCR topics, and will include various problem-based learning approaches. The average grade of all sessions over the three terms will be determined, and an average of 80% or greater is required to achieve a grade of Satisfactory.

Prerequisites: None
Term offered: I, II, III Longitudinal
Year offered: Annually
Hours: Lecture 2; Discussion 14
Instructor: Toliver-Kinsky

Teaching in Biochemistry (BBSC 6133)

In this course, students will learn and practice skills necessary to facilitate small group learning teams. At the end of the course, students will: (a) Be able to distinguish between actual content (the concept the small group is working on) and process (how the group works on acquiring and developing knowledge on that concept); (b) Understand the various group member roles related to both content and process; (c) Have practiced methods for effective communication; (d) Have learned effective questioning skills; (e) Have practiced effective listening skills and empathy; (f) Be capable of providing effective feedback; (g) Be capable of maintaining engaging group discussions and (h) Be able to provide constructive evaluations. Grading will be on a Satisfactory/Unsatisfactory basis. A grade of satisfactory will be dependent on (a) attendance of the student to all scheduled course workshops, facilitator previews, and small-group problem solving sessions, and (b) acceptable performance as a facilitator judged by the course director with input from students enrolled in the BBSC 6303 Biochemistry course.

Credit: 1
Prerequisites: Consent of Instructor
Term offered: I
Year offered: Annually
Hours: Discussion 1
Instructor: Smith

Frontiers of Science (BBSC 6195)

Syllabus
This longitudinal course provides students the opportunity to hear about the latest advancements and techniques in a wide variety of biomedical sciences. Students are required to attend seminars by on- or off-campus speakers. Students choose seminars to attend on the basis of student interest and/or program recommendations. The course will begin in the Fall term and will extend over all 3 terms of the academic year. Students register for it in all 3 terms. A grade of “G” (longitudinal) will be assigned at the end of the Fall and Spring terms, and a single, 1-hour course grade will be assigned at the end of the Summer term. Grades will be satisfactory (S) or unsatisfactory (U) based on attendance and submission report forms for the designated required number of seminars each term.

Prerequisites: Student in PREP program or consent of instructor
Term offered: I, II, III Longitudinal
Year offered: Annually
Hours per week: 1
Instructor: Toliver-Kinsky, Vargas

Biostatistics (BBSC 6222)

Syllabus

This is a required core course in the Basic Biomedical Science Curriculum (BBSC) which will provide students in the basic sciences with an introduction to statistical thinking, Specific topics include basic summaries, probability and distributions, inference, experimental design, hypothesis testing, and statistical modeling. Grading will be based on performance on homework and lab assignments, quizzes, a final take-home exam, and class participation including paper discussions. Students will learn about the difference between populations and samples; the proper way to describe experimental results based on descriptive statistics and visualization strategies; frequency distributions; when to apply and how to perform statistical tests such as t-tests, ANOVA, linear regression, correlation tests, nonparametric tests, and chi square analysis; power analyses and sample size calculations. Each concept will be reinforced by a computer lab exercise. Grades will be calculated based on the performance of class participation, in-class quizzes, labs and an open book take-home examination.

Prerequisites: None
Term offered: II
Year offered: Annually
Hours per week: Laboratory 2; Lecture 1.5
Instructor: Chakraborty

Cell Biology (BBSC 6302)

Calendar

Syllabus
This is a required foundation course in the Basic Biomedical Science Curriculum (BBSC). It is a sixteen-week course taught throughout the term to acquaint students with the basic principles of modern cell biology. The topics to be covered include regulation of basic cellular activities including functions of membranes, ion channels, cell organelles, protein targeting, signaling, cell development, cytoskeleton, cell cycle, cell death, cell biology of disease (e.g. mitochondria in health and disease, diabetes, obesity), cellular basis of the immune response, adaptive Immunity and stem cells. Grading will be based on small-group sessions, and examinations.

Prerequisites: none.
Term offered: II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Oberhauser

Biochemistry (BBSC 6303)

Syllabus
2020 Calendar

This is a required foundation course in the Basic Biomedical Science Curriculum (BBSC). The primary goal of the course is to train students to develop their ability to critically analyze data. The course deals with the fundamental forces that provide the bases for molecular interactions, and the translation of these forces into the structure and function of proteins and nucleic acids. Emphasis will be on the principles that give rise to these forces; on applying the principles to biochemical problems; and on the application of the principles in understanding macromolecular structure and function. The course also provides a survey of techniques relevant to subjects discussed. In addition the course presents the general principles of regulation in metabolism, molecular signaling and synthesis and function of different biomolecules as they apply to developing an understanding of regulatory mechanisms in homeostasis and disease. Grades will be determined based on performance on written examinations, problem-solving homework and performance in small-group discussion sessions.

Prerequisites: At least one-year college-level biology and chemistry; biochemistry recommended or consent of instructor
Term offered: I
Year offered: Annually
Hours per week: Lecture 3; Discussion 1
Instructor: Pettitt, Smith

Biochemistry, Cellular and Molecular Biology Course Descriptions

Research (BCMB 6097)

Work is designed to introduce the student to the techniques and philosophy of scientific research and to guide the development of a research problem in the major area of concentration. Provides laboratory experience prior to entering candidacy. Grade is determined by a written progress report signed by mentor and program director.

Term offered: Fall, Spring and Summer
Year offered: Annually

Thesis (BCMB 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Dissertation (BCMB 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Current Concepts in Biochemistry & Molecular Biology (Faculty Seminar) (BCMB 6111)

The objective of this course is to introduce students to current research in the general areas of biochemistry and molecular biology through attendance at faculty seminars. Students will be required to attend departmental seminars in the fall and spring terms. Students may choose from Biochemistry and Molecular Biology departmental seminars and Sealy Center for Structural Biology and Molecular Biophysics seminars, and special seminars as communicated by the course director or coordinator. The required number of seminars to be attended will be approximately 75% of the departmental seminars offered that term. Grades will be satisfactory (S) or unsatisfactory (U) based on in person seminar attendance. An official attendance sheet will be available at each departmental seminar. If a student attends a virtual seminar or non-departmental seminar then completion of a seminar summary, to include the objectives/hypothesis of the research presented, methodology significant findings, and implications of research must be submitted to the course director within one week of the seminar date. Attendance or completion of the seminar summary for 12 of 16 seminars is required for satisfactory course completion.

1 Credit Hour
Prerequisite: None
Instructor: Yunfeng Chen
Term offered: Fall and Spring
Year offered: Annually
Hours per week: 1 hour per seminar attended

Biomolecular Dynamics (BCMB 6115)

In this course, students will learn about experimental research on structural dynamics of biomacromolecules. Structural dynamics of various systems such as enzymes, molecular motors, cell surface receptors, chromatin / chromosome, and viral particles will be discussed. Covered methods include nuclear magnetic resonance (NMR),crystallography, cryo-electron microscopy, fluorescence imaging, and single-molecule techniques. The primary focus will be on applications rather than on the principles of the methodologies. Students will read highly influential papers on structural dynamics of macromolecules, which are selected by the instructors. Each instructor gives two sessions: in one session, the instructor gives an introductory lecture on methods highly relevant to the papers selected for discussion; in the following session, the instructor leads discussion while the students present the papers. This is an elective course designed for non-first-year graduate students. Grading will be based on discussion and a final exam.

1 Credit Hours
Instructors: Junji Iwahara
Term offered: Spring
Year offered: Annually
Hours per week: 1 hour, 15 weeks

Seminar (BCMB 6195)

The course provides practical training i n seminar presentation skills, critical thinking, and peer evaluation. Students must register for the Seminar course (BCMB 6195) in years 2, 3 and 4 (three consecutive years after they enter into the BCMB graduate program). Each student will attend student seminars every week and, in addition, each student will present one research seminar per year in their third and fourth years (3rd year students: 30 min seminar; 4th year students: 1 hr seminar). M.D./Ph.D. students in the BCMB Program will take the Seminar course when they are full-time graduate students. They only need to take this course two times, presenting once during their Ph.D. training. Each week there will be a seminar for all students (Friday, 1:00 - 2:00 pm). All students are expected to ask questions during seminars and must submit a written evaluation of each speaker by 12 pm on the Friday following the seminar.

Prerequisite: None
1 Credit Hour
Instructor: Michelle Ward
Term offered: Spring
Year offered: Annually
Hours per week: Lecture 1

Genomics, Proteomics and Bioinformatics (BCMB 6208)

Lecturers will select seminal recent papers on principles and novel techniques used in the interpretation of DNA micro arrays, protein arrays and data mining of structural and functional databases. Each student is requested to read all papers, and present one paper with additional background information in a 45-minute lecture. The faculty will provide additional advice on the context of this paper in the literature, might complement the student presentation with comments from his expertise on particular techniques, and will stimulate the discussion on the content of paper.

Prerequisite: Consent of instructor or BBSC core
2 Credit Hours
Instructor: H. Spratt, W. Braun, J. Wiktorowicz
Term offered: Fall
Year offered: Annually
Hours per week: 2, 10 Week Course

Tutorial in DNA Replication, Repair, and Mutagenesis (BCMB 6209)

This will address various aspects of DNA replication, repair, and mutagenesis. A particular focus point will be the interrelationships among repair processes and other important cellular functions. The aim is to develop students' fundamental knowledge of the research area, and their abilities to comprehend, evaluate and present scientific material. Grading bases on written critiques of papers, on participation in the discussions, and quality of the presentation.

Grades will be calculated based on performance in the following:
In-class presentation of topic chosen (60%)
Class participation (40%)

Prerequisite: Consent of instructor or BBSC core
2 Credit Hours
Instructor: S. Prakash, L. Prakash
Term offered: Fall
Year offered: Annually
Hours per week: 2, 10 Week Course

Structural Biology and Biophysical Chemistry (BCMB 6224)

This course deals with the role of biophysical methods, including structural biology, solution biophysical and computational approaches, in the study of proteins in the proteomic era. The focus is on conformational changes and macromolecular assembly, the utility of dynamic and static structural data, and the necessity to combine experimental approaches to obtain a full functional description.

Prerequisite: Consent of instructor or BBSC core Consent of instructor or BBSC core
2 Credit Hours
Instructor: W. Yin
Term offered: Spring
Year offered: Annually
Hours per week: 2, 10 Week Course

Structure-Based Drug Discovery (BCMB 6238)

The drug discovery process requires a combination of different disciplines with the ultimate goal of bringing to the marketplace a drug that can treat health problems. However, the current experimental strategy of drug discovery and development is expensive, inefficient, and lengthy. Structure-aided drug discovery constitutes an advantageous strategy to improve the drug discovery process with less investment of money and time. Using didactic lectures and computer-based interactive projects, this course will provide an in-depth introduction to the theoretical and practical aspects of structure-aided drug discovery. At the completion of this course, participants will have become skilled in applying the software, databases, and concepts necessary to independently initiate a computer-based drug discovery project.

Prerequisite: None
2 Credit Hours
Instructor: Stan Watowich
Term offered: Summer
Year offered: Annually
Hours per week: 6 hours, 7 weeks

Biological Fluorescence (BCMB 6239)

Course description and objectives: The course addresses major theoretical and practical aspects of fluorescence spectroscopy as encountered in biological research of macromolecular interactions in solution. The subjects include discussions of fluorescence intensity measurements, emission and excitation spectra, inner filter effect, magic angle, fluorescence lifetime, quantum yield determination, dynamic and collisional quenching problems, and Fluorescence resonance energy transfer (FRET) theory. Practical aspects of the course will focus on the experimental design, approaches and applications of measurement of fluorescence, including steady state and time dependent fluorescence anisotropy as applied to macromolecular structure analyses, and quantitative fluorescence titration methodologies in examining energetics of macromolecular interactions

Prerequisite: Undergraduate background in Biochemistry, Biology, Chemistry
2 Credit Hours
Instructor: Wlodek Bujalowski
Term offered: Summer
Year offered: Annually
Hours per week: 4 hours, 8 weeks

Probabilistic and Statistical Methods in Bioinformatics (BCMB 6240)

Biomedical research is rapidly becoming data-intensive and researchers generate and use increasingly large, complex, multidimensional, and diverse datasets. The data sets are often structured, but with non-trivial structure inconsistent with classical experimental designs. The ability to access, process, analyze, understand, extract value from and disseminate data is becoming critical. Multiple skills are required for these purposes. In this course, we will concentrate on some of the key probabilistic, statistical concepts and machine learning techniques actively used in modern biomedical data analysis. Examples of data processing will be provided from proteomics experiments and standard databases available in R. The grading is based on class participation, homework assignments, midterm and final exams.

Prerequisite: Some familiarity with probability concepts and coding basics.
Instructor: Rovshan G. Sadygov
Term offered: Spring, annually
Hours per week:2 hours, 12 week

Diffraction Methods in Structural Biology (BCMB 6241)

This course is a series of lectures with in-class exercises and homework assignments that will cover the following topics: 1) the physical and mathematical basis of diffraction; 2) the relationship between the atomic structure of a periodic object and its diffraction pattern; 3) geometric interpretation of diffraction and the reciprocal space; 4) solution of the crystallographic phase problem; 5) refinement and accuracy of atomic models derived from X-ray diffraction data; 6) practical application of obtained knowledge to solving the crystal structure of a protein.

The course explains how Thomson scattering becomes a diffraction pattern in a periodic object. The accompanying math, including the Fourier transform, is given in the form of simple concepts. A significant amount of time is dedicated to the description and explanation of algorithms used in X-ray data processing programs. The crystallographic phase problem and methods for its solution are discussed at length. The basics of crystallographic refinement are explained.

2 Credit Hours
Instructors: Petr Leiman
Term offered: Spring
Year offered: Annually
Hours per week: 2 hours, 16 weeks

Molecular Biophysics (BCMB 6334)

In this course, students learn thermodynamics and kinetics for biological molecules. Both theoretical and experimental aspects are covered. Students also learn the MATLAB software so that they can use it as a tool for their own research.

3 Credit Hours
Instructors: Whitney Yin (Course director), Michael Sherman, Krishna Rajarathnam Thomas Smith
Term offered: Spring
Year offered: Annually
Hours per week: 3 hours, 16 weeks

Macromolecular Structure (BCMB 6336)

Introduction to proteins and nucleic acids, with emphasis on physical underpinnings. Topics include primary, secondary, and tertiary structure, sequence analysis, energetics and predictive methods. The final course grades will be based on the performance of two exams, problem sets, and attendance.

3 Credit Hours
Instructors: Wlodek M. Bujalowski, PhD, Andres Oberhauser, PhD, Stanley J. Watowich, PhD
Term offered: Fall
Year offered: Annually
Hours per week: 3 hours, 16 weeks

Statistical Thermodynamics (BCMB 6341)

This is an advanced elective course in fundamental biophysics. We will explore topics concerning the connection between the microscopic properties of atoms determined by quantum mechanics with the macroscopic properties determined by thermodynamics. We wish to understand the connection between atomic or molecular properties and bulk behavior as happens in solutions or cells. The central objective of the course is how to get from 10^23 variables (like position, velocity, species) to a small number of thermodynamic observables. The tools of statistics and probability theory will be employed to understand the behavior of large numbers of atomic/molecular systems via their mechanical laws and properties to describe solids, liquids and biopolymers. Lectures, online course materials, and homework problems will be used for each class period.

Prerequisite: No graduate course prerequisites. Undergraduate thermodynamics, differential equations, and some quantum mechanics are recommended.
3 Credit Hours
Instructor: B.M. Pettitt
Term offered: Spring
Year offered: Annually
Hours per week: 3 hours, 15 weeks

CLCS Course Descriptions

CLCS 6097 Research

This course initiates the formal research training directed toward a degree in Clinical Science. During this course, the student will select a supervisory committee, submit a full written proposal for approval, orally defended the approved written proposal and request admission to candidacy. Grading will be based upon the student's level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).

CLCS 6098 Thesis

Once admitted to candidacy, it is required for students pursuing a Master of Science degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).

CLCS 6099 Dissertation

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).

CTPS Course Descriptions

Mentored Research for Postdoctoral Scholars (CTPS 6001)

No classroom attendance required. Research report due online at end of term.

This course consists of the training the postdoctoral scholar’s supervisor provides regularly in the laboratory and, thus, requires no class attendance. When research prevents a postdoc from leaving the lab bench, he or she may register only for Mentored Research. This course is designed to fine-tune postdocs' basic research skills in the laboratory or other location where the research takes place. The course consists of research in keeping with the postdoc's field, and overseen by the mentor.
*Enrollment limited to Postdoctoral Fellows

Credit Hours/Semester: Limited to 3.0

Research Seminar (CTPS 6101)

Seminar attendance, as required by mentor. Personal verification of attendance due at end of term.

This course is designed for postdocs to observe and learn to develop and present seminars about their research. After completing the course, students should be able to discuss their research with scientists in a way that helps advance the project; develop a presentation that concisely presents the research; develop learning objectives that the audience will receive from the presentation; demonstrate the ability to engage the audience in the research project; and observe and objectively assess and discuss another scientist's research.
*Enrollment limited to Postdoctoral Fellows

Credit Hours/Semester: 1.0

Journal Club (CTPS 6102)

Journal club attendance, as required by mentor. Personal verification of attendance due at end of term.

This course is designed for postdocs to learn to critically read and evaluate scientific journal articles and discuss them with colleagues; to lead discussions about published research developments, and to plan discussions for journal club meetings.

*Enrollment limited to Postdoctoral Fellows

Credit Hours/Semester: 1.0

Career Planning (Individual Development Plan) (CTPS 6103)

No classroom attendance required.

This course is comprised of writing your own Individual Development Plan (IDP) and discussing it with your mentor during the semester of registration. You must write your IDP, discuss it with at least one faculty mentor, and send a copy of the signed IDP and your CV to the Postdoctoral Affairs Office. There is no class to attend.
*Enrollment limited to Postdoctoral Fellows

Credit Hours/Semester: 1.0

Animal Research Topics and IACUC Protocol Essentials (CTPS 6107)

This course is designed to prepare postdocs and advanced graduate students with information pertaining to the research use of animals. After completing the course, researchers can explain the composition and functions of the Institutional Animal Care and Use Committee (IACUC), including IACUC protocol submission procedure and the committee’s review process. Write an IACUC protocol suitable for submission to the IACUC.

Credit Hours/Semester: 1.0

General Laboratory Safety and Good Laboratory Practices (CTPS 6108)

Online and classroom participation required.

This course is designed to prepare postdoctoral scholars and advanced graduate students with basic tools and information about biomedical laboratory safety and the FDA's Good Laboratory Practices (GLP) regulations, codified under Title 21 Part 58 of the Code of Federal Regulations.

Credit Hours/Semester: 1.0

Research Project Management 101 (CTPS 6109)

This course is designed to provide training in the management of sponsored research projects. After completing the course, students should be prepared to discuss the laws and regulations related to research finances; discuss the life cycle of a successful grant application; prepare the components of a grant proposal; report effort expended on a research grant; manage financial aspects of a grant; discuss cost principles related to grant management; and close out a grant.

Credit Hours/Semester: 1.0

Preparing for Proposals and Publications (CTPS 6110)

This course is designed to provide tools necessary to prepare to write grant proposals and research manuscripts. After completing the course, students should be prepared to use the campus online search program, InfoEd, to identify funding opportunities and receive funding alerts; search for and identify investigators with similar research interests who may be collaborators, consultants or mentors; write clearly and avoid common mistakes in grammar, punctuation and scientific writing styles; and cite manuscripts submitted to PubMed Central and clinical trials registries in proposals.

Credit Hours/Semester: 1.0

Effective Presentation Skills (CTPS 6111)

This course is designed to prepare postdoctoral scholars and advanced graduate students with basic tools to design and deliver effective presentations using sound principles of public speaking. It will also help them learn to control nervousness when speaking before a group.

Credit Hours/Semester: 1.0

Navigating the IRB and Investigator Responsibilities (CTPS 6113)

This course is designed for those with responsibilities in human subject’s research. The course prepares researchers to: Identify the purpose, history and structure of the Institutional Review Board (IRB); Develop a framework for research with humans and human tissues, as well as vulnerable populations; Develop a protocol for submission to and review by the IRB; Report adverse events related to human research; Develop forms for obtaining informed consent from potential research subjects; and Develop acceptable methods for obtaining informed consent.

Credit Hours/Semester: 1.0

TRM1 - Team Building and Meeting Management (CTPS 6115)

This course is designed to prepare postdocs and advanced graduate students with the basic tools to develop their management skills for leading translational research projects. With completion of this course, the participant will be able to: diagnose team effectiveness and dynamics; understand the role of norms, roles, goals, and team procedures, and to apply techniques to develop such; plan and facilitate both traditional and virtual meetings in a highly professional manner; use facilitation tools and techniques to develop and lead teams; follow established models of teams and groups, and apply the latest practices (cross functional teams, new product teams) to translational team efforts.

Credit Hours/Semester: 1.0

Translational Research Management 2: Effective Leadership (CTPS 6116)

This course is designed to prepare postdocs and advanced graduate students with the basic tools to develop their managerial skills for leading translational research projects.

Prerequisites: None
Year offered: Annually
Instructor: Sara Dann

Effective Lab and Resource Management (CTPS 6121)

This course is designed to prepare postdocs and advanced graduate students with the basic tools to develop and lead a laboratory in academia or industry, manage resources and personnel effectively, and evaluate funding and technology transfer options.

Credit Hours/Semester: 1.0

Presentation Skills Practicum (CTPS 6122)

This course is designed to provide postdoctoral scientists and senior graduate students with experience in presenting a seminar and learning to perform critical reflection as a routine part of the evaluation process, in order to instill a more scholarly approach to this most important part of the scientific process.

Credit Hours/Semester: 1.0

Undergraduate Teaching – Observation (CTPS 6125)

This 2-phase course is designed to prepare postdoctoral scholars to teach science courses in the college setting, under the guidance of a faculty mentor at a local undergraduate college or school. The first phase is for observing several faculty members with different teaching methodologies. The second phase is the classroom teaching segment.

*Enrollment limited to Postdoctoral Fellows

Credit Hours/Semester: 1.0

Undergraduate Teaching – Experience (CTPS 6126)

This course focuses on preparing Postdoctoral fellows for teaching science at the undergraduate level. Under the guidance of a faculty mentor at a local undergraduate college, Galveston College, Postdoctoral fellows will complete at least 12 hours of classroom preparation, teach a segment of a Science course, provide a laboratory teaching activity, and write a self-evaluation of the teaching experience. The undergraduate courses for this training course may include Biology for Science Majors, Microbiology,Nutrition, Anatomy & Physiology, and Chemistry. Overall course grade of S (satisfactory) or U (unsatisfactory) calculated based on preparation & delivery, student evaluations of the postdoctoral instructor, faculty evaluation of the postdoctoral linstructor and a self-evaluation of teaching experience. /p>

*Enrollment limited to Postdoctoral Fellows

Prerequisites: Permission of the Postdoctoral Fellow’s mentor and the course director; successful completion of CTPS 6125 Undergraduate Teaching Practicum-Observation.

Term offered: II
Year offered: Annually
Instructor: Sara Dann

TRM5 – Problem Solving and Decision Making (CTPS 6128)

100% Online Course

The course is designed for those who wish to develop specific skills and knowledge in the management of scientific projects and translational science. This course is set up for a sixteen-week semester and is structured as a completely asynchronous course to assist with the time management needs of those interested, but for whom a traditional delivery model would be difficult. Seven specific modules are developed along the lines of similar context.

Credit Hours/Semester: 1.0

TRM6 – Translational Research Project Management (CTPS 6129)

The course is designed for those who wish to develop specific skills and knowledge in the management of scientific projects and translational science.

Credit Hours/Semester: 1.0

Application for Funding (CTPS 6131)

Financial support in the form of grants, cooperative agreements, and contracts is essential to support and advance biomedical research. This course is designed to provide postdoctoral scientists with experience in preparing and submitting an application for funding. Participants will spend time with their supervising mentors: 1) identifying and selecting a funding opportunity; 2) determining the application submission date; 3) planning the application; 4) writing and completing the application; and 5) submitting the application. Following submission, participants will perform a self-reflection analysis to identify the proposal's strengths and general areas in need of improvement. A satisfactory grade is based on students submitting an application for funding and a verification form describing the activity. Credit will not be given for future dated experience.

Prerequisites: None
Term offered: I, II, III
Year offered: Annually
Instructor: Sara Dann

Outreach Activity (CTPS 6133)

This course is designed to provide postdoctoral scientists with outreach experience. Postdoctoral scientists shall receive credit for having played a substantial role in a scientific or educational outreach activity such as serving as a science fair judge or giving a lecture or lab demo at a primary or secondary school.

Credit Hours/Semester: 1.0

Conference Presentation (CTPS 6134)

This course is designed to provide postdoctoral scientists with experience in preparing and presenting a poster at a local, national, or international scientific meeting, and performing critical reflection of feedback received in a collegial atmosphere. Participants will spend time with their mentors: 1) preparing and submitting an abstract for conference presentation; 2) preparing their poster presentations (selecting salient research findings, creating appropriate figures, etc.); 3) give the presentations; 4) review feedback by conference attendees or course faculty; and 4) prepare their own reflective materials, mostly in the form of “minute-paper” self-evaluations.

Credit Hours/Semester: 1.0

International Collaborations (CTPS 6136)

This course will cover different aspects of international collaborations ranging from co-authorship of scientific manuscripts to development of research projects. Cultural aspects, geographical distances as well as political and economic reasons heavily influence these collaborations. The course will be interactive, with emphasis on student’s development of a simulated international project. This will encompass searching for information and discussion on diverse topics linked to that task. In addition, the course will have the participation of lecturers with experience in international collaboration with different countries, mostly through the development of research projects or multi-centric clinical trials.

Credit Hours/Semester: 1.0

Becoming an Effective Mentor (CTPS 6138)

This course is designed for postdocs and advanced graduate students who are interested in mentoring trainees in a laboratory setting. At the successful completion of this course the students will have acquired the knowledge and practical understanding of mentoring and how to properly guide their mentees to perform their job to the best of their ability. The students in this course will have the necessary knowledge and tools to develop tailored Performance Development Plan for each of their mentees.

Prerequisites: None
Year offered: Annually
Instructor: Tom Green

Classroom Teaching Practicum (CTPS 6303)

This course is designed to prepare postdoctoral scholars to teach science courses in the college setting, under the guidance of a faculty member at a local college.

Credit Hours/Semester: 3.0

Human Pathophysiology and Translational Medicine Course Descriptions

Clinical Encounters (HPTM 6071)

This course will consist of clinical encounter sessions with HPTM clinical faculty. Students will gain hands-on experience and mentorship in conducting T1 translational research projects in their specific area of scientific and clinical interest. The goals of the clinical encounter sessions are to continue the development of interprofessional communication skills between scientists (students) and physicians (clinical mentor), have the students gain a focused knowledge of current standards of diagnosis and treatment of a specific disease or injury, discuss the limitation of current methods of clinical care, and explore or identify potential areas for future translational research projects for the improvement of current standards of care. Clinical Encounter session activities will include: physician "shadowing" to observe patients afflicted with the disease or injury of interest and/or attending interdisciplinary clinical conference that discuss disease processes and/or patient care. The CE sessions will also allow time for l) student-clinical mentor planning sessions to discuss scheduling and goals for the CE course in the beginning of the course, and 2) time for the student to write 1·2 pages reflection essays on how the CR rotation enhanced their understanding of the specific disease or clinical problem as it relates to their translational research project. The final course grade is determined based on the criteria established between the mentor and student and reported on the Student Evaluation Report form.

Prerequisites: HPTM 6291, POTS l and HPTM 6292, POTS 2.
Terms offered: I, II, III
Years offered: Annually
Hours per week: Laboratory 6

Internship Regulated Nonclinical Studies (HPTM 6072)

The ORNCS faculty/staff will offer practical training on development/use of study protocols, standard operating procedures, study-specific and facility documentation, equipment qualification, data/sample retention, and Quality Control/Quality Assurance (QC/QA). Trainees participating In this internship will shadow study directors, scientific/technical personnel, records management and archiving personnel, and quality assurance unit (QAU) personnel. Interns will gain an advanced understanding of the FDA Good Laboratory Practice (GLP) and Animal Rule regulations, Implementation and operation of quality management systems, and the design, execution, reporting and quality oversight of animal efficacy studies supporting licensure of vaccines and other medical countermeasures. Trainees participating In this Internship may also be able to attend the UTMIHDA¿¿sponsored training activity, ·Achieving Data Quality and Integrity In Maximum Containment Laboratories-, which Is held annually at the National Institutes of Health In Bethesda, MO, focusing on animal mode regulatory expectations under the FDA's Animal Rule. Grading (satisfactory/unsatisfactory) Is based on participation, attendance, and effective completion in assigned tasks.

Prerequisites: Consent of Instructor. Participation in Good Laboratory Practice training provided by the ORNcS-FDA-GLP Regulations In the Academic Setting.
Terms offered: I, II, III
Years offered: Annually
Hours per week: Practicum

Research (HPTM 6097)

Formal research directed toward the Doctor of Philosophy degree programs. Grading will be based upon the student's level of performance as reported by the student's research supervisor and will be assigned as satisfactory or unsatisfactory in a Mentor Report. Work is designed to introduce students to the techniques and philosophy of scientific research and to guide them in the development of a research problem in their major area of concentration. At the end of the registered term, students are required to write a one-page description of their research work.

This course is taken after a student has passed the qualifying exam. Each student may enroll in this course for a maximum of three terms before becoming a candidate.

Prerequisites: Approval of Program Advisor
Terms offered: I, II, III
Year offered: Annually
Hours per week: Variable

Thesis (HPTM 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Dissertation (HPTM 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Translational Research Seminar Series for HPTM Graduate Students (HPTM 6109)

This seminar series PROVIDES OPPORTUNITIES FOR Human Pathophysiology and Translational Medicine (HPTM) graduate and Translational Research Track (TRT) medical students to present their research to their peers and interested faculty in a scholastic setting, maintain contact with TRT students and gain an understanding of the translational insights of the medical students doing their clinical rotations, and interface with experienced clinicians and scientific competencies. Grading will be based on: seminar and post-seminar discussion attendance (70%), professionalism (5%), career building (10%) and the annual presentation of a student research update seminar (15%). Final grades will be calculated based on the standard A-F scale.

Prerequisites: Student must be entering second year in the HPTM program to enroll
Terms offered: I, II
Years offered: Annually
Hours per week: Discussion 1; Seminar 1

Practice of Translational Sciences – Modules I, II, III and IV (HPTM 6291, 6292, 6293, 6113)

6291 MODULE I: PRACTICE OF TRANSLATIONAL SCIENCE (2 Credits)

Students in this course will participate in active, student-directed cooperative learning exercises in small groups to explore foundational concepts that address basic competencies of translational scientists. Students will be concurrently enrolled with medical students in Gross Anatomy and Radiology course (HPTM 6405). Topics explored during the POTS 1 courses will include scientific knowledge of human physiology and pathology as well as traditional basic sciences such as cell biology, molecular biology, genetics, etc. Concepts will be linked to Problem Based Learning cases studies in the GAR course (HTPM 6405). Students will also spend significant time in groups exploring and applying concepts related to other core competencies of translational scientists, such as teaching, professionalism, communication, and management. Grades will be based on weekly quizzes (20%), final written exam (20%), small group participation and problem-solving (20%), and other (oral presentation, reflective writing, peer assessment, learning portfolio) (40%).

Prerequisites: Students must be enrolled in the HPTM program. HPTM 6405 must be taken concurrently.
Terms offered: I
Years offered: Annually
Hours per week: Conference/Discussion 4

6292 MODULE II: PRACTICE OF TRANSLATIONAL SCIENCE (2 Credits)

Students in this course will participate in active, student-directed cooperative learning exercises in small groups to explore foundational concepts that address basic competencies of translational scientists. This course will emphasize core principles in physiology incorporating biochemistry, molecular biology, genetics, etc. Grades will be based on weekly quizzes (20%), final written exam (20%), participation in small group activities (20%), and other ( (oral presentation, reflective writing, peer assessment, learning portfolio) (40%).

Prerequisites: Students must be enrolled in the HPTM program. HPTM 6291 and HPTM 6405. HPTM 6332 must be taken concurrently.
Terms offered: I
Years offered: Annually
Hours per week: Conference/Discussion 4

6293 MODULE 3: PRACTICE OF TRANSLATIONAL SCIENCE (2 Credits)

Students in this course will participate in active, student-directed cooperative learning exercises in small groups to explore foundational concepts that address basic competencies of translational scientists. This course will emphasize core principles in physiology and pathology incorporating cell injury and adaptation, inflammation, immunologic diseases, microbiology, environmental and genetic diseases. Grades will be based on weekly quizzes (20%), final written exam (20%), participation in small group activities (20%), and other (oral presentation, reflective writing, peer assessment, learning portfolio) (40%).

Prerequisites: Students must be enrolled in the HPTM program. HPTM 6405, HPTM 6291, HPTM 6332, HPTM 6292
Terms offered: II
Years offered: Annually
Hours per week: Conference/Discussion 4

HPTM 6113 MODULE 4: PRACTICE OF TRANSLATIONAL SCIENCE IV (1 Credits)

This eight-week course is the fourth module of the Practice of Translational Science course, the foundational, discipline-specific course of the HPTM curriculum. The students will be engaged in a longitudinal, individual grant writing experience that began in POTS Ill. POTS IV is a continuation of the grant exercise; however, there will be greater focus on the Experimental Methods and Approaches in this course. In general, the classes will be designed to be experiential with a "how to" focus. Students will meet in the instructors' labs and be immersed in datasets, or experimental samples for assay analyses. Grades will be based on: final written grant and competency assessment. Competency assessment includes work exercises, proposal papers, group projects, oral presentations, quizzes, and post-class assignments.

Prerequisites: Students must be enrolled in the HPTM program. HPTM 6291, POTS 1; HPTM 6292, POTS 2; HPTM 6293, POTS 3
Terms offered: II
Years offered: Annually
Hours per week: Lecture 2

Interprofessional Translational Research Design Course (HPTM 6295)

The Interprofessional Translational Research Design (IPTRD) course will team HPTM students with UTMB Medical Students in the Translational Research Track in identifying a translational problem and designing translational research projects. The course will focus development of key research design and collaborative competencies. Major emphasis will be on biostatistics and research design, team building, professional identify development, inter-professional communication and oral presentation skills. The course will meet for three, two hour sessions weekly. Teaching methodology will use active learning modalities such as guided inquiry, moderated discussion, workshop sessions and seminar presentations. Course grades will be based on small group discussions participation, written critiques of research articles, and research proposal developed as an interprofessional pair.

Prerequisites: Currently enrolled in the HPTM program having satisfied the requirements of HPTM 6291, 6292, HPTM 6293 and HPTM 6294 or a UTMB Medical School Student enrolled I the Translational Research Track
Terms offered: III
Year offered: Annually
Hours per week: Lecture 6

Introduction to Big Data Visual Analytics (HPTM 6284)

The accelerated growth and complexity of biomedical data far exceeds our cognitive abilities to exploit it for the prevention, diagnosis, and treatment of diseases. A promising approach to bridge this gap is through the emerging field of visual analytics defined as the “science of analytical reasoning facilitated by interactive visual interfaces.” This course provides the theoretical foundations and practical methods related to visual analytics focused towards the analysis and comprehension of large and complex biomedical datasets (e.g., genomic data, and electronic health records). The theoretical foundations will focus on the principles related to cognition, computation and graphic design. The practical methods will focus on hands-on experience in using commercial (Tableau and Pajek) and a research prototype (MODIM) requiring no programming. Through a required project, students will have the opportunity to integrate their theoretical and practical knowledge of big data visual analytics to analyze, comprehend and present complex patterns in a large biomedical dataset. Grading scale will be A-F.

Prerequisites: Biostatistics – BBSC 6222 or Interprofessional Translational Research Design – HPTM 6295, or with the permission of the instructor
Terms offered: Summer, 2nd Block
Years offered: Annually
Hours per week: Conference/Discussion 4

Gross Anatomy and Radiology (HPTM 6405)

In this course, graduate students in the HPTM curriculum will participate in problem based learning, anatomy lab, and lectures together with selected medical students in the Integrated Medical course of the same name. This inter-professional learning opportunity will allow medical and graduate students to learn with, from and about each other with the goal of instilling collaborative competencies for translational research. Grades will be based on participation in small group problem based learning sessions (45%), midterm and final written exams (25%), mid term and final laboratory practical exams (22%), and self study cross sectional anatomy tutorial (8%).

Prerequisites: Enrollment in HPTM
Terms offered: I
Year offered: Annually
Hours per week: Laboratory 6-8; Lecture 4; Conference/Discussion 3

Pathobiology and Host Defense for HPTM Students (HPTM 6406)

In this course, graduate students in the HPTM curriculum will participate in problem-based learning ((PBL) sessions, pathology lab session and lectures together with selected medical students in the integrated Medical Curriculum course of the same name. PBL and lab sessions involve case-based studies of various diseases. Major basic science topics include general pathology, histopathology, basic immunology and microbiology. The inter-professional learning opportunity will allow medical students and graduate students to learn with, from and about each other with the goal of instilling collaborative competencies for translational research. The course will be complemented by the HPTM course Practice of Translational Science Module 3. Grades will be based on mid-term exam, final exam, lab exam, PBL evaluation, PBL graded quizzes and graded weekly quizzes. Assessment modalities for HPTM students are tailored specific for the program-specific objectives, hence the use of essay examinations in addition to course development multiple choice assessments.

Prerequisites: HPTM 6405, HPTM 6291, HPTM 6332, HPTM 6292. Students must be enrolled in the HPTM program
Terms offered: II
Year offered: Annually
Hours per week: Lecture 5; Discussion 6; Laboratory 2

Interdisciplinary Course Descriptions

Independent Study (INTD 6088)

This 8-week interdisciplinary course provides graduate students the opportunity to expand their knowledge in preparation for their capstone, thesis or dissertation (e.g., learn a particular technique or a skill, read on a particular subject, etc.). The detailed or in-depth study would be in a specific topic area as agreed upon by the student and supervising faculty member. A written report at the end of the block is required, summarizing what has been learned. Overall course grade is based on meeting the objectives set forth for the course, and the requirements for the report.

Prerequisites: None
Terms offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 3-6
Instructor: Jupiter

Capstone (INTD 6094)

This interdisciplinary course is for students pursuing a Master’s degree and who are not doing a thesis or dissertation but instead are carrying out a project or capstone. The project/capstone consists of any of the following activities: i) Writing a review paper on a topic that the student will select together with a mentor and/or a committee; ii) Writing a short research paper on a topic that the student will select together with a mentor and/or a committee; iii) Hands-on activity that would result in generating/optimizing a protocol or establishing an assay; iv) Computational exercise around a well-defined scientific project that includes bioinformatics or data analysis; v) Internship in industry with written report. Grades are based on a satisfactory or unsatisfactory performance.

Prerequisites: None
Terms offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 3-6
Instructor: Jupiter

Research (INTD 6097)

This interdisciplinary course varies in credit according to the work performed. It is intended for formal research on thesis or dissertation project under the direction of a supervising professor directed toward the Doctor of Philosophy or Master of Science degree programs. This interdisciplinary course is designed to introduce the student to the techniques and philosophy of scientific research and to guide the development of a research problem in the major area of concentration. At the end of the registered term, students are required to write a one-page description of their research work. Grade is satisfactory (S) or unsatisfactory (U).

Prerequisites: None
Terms offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 1-9
Instructor: Jupiter

Comprehensive Grant Writing (INTD 6103)

This eight-week course is designed to advance the knowledge that graduate students receive in basic grant-writing courses their programs may offer. At the same time, it will teach postdocs and graduate students who have not learned the basic skills what they need to know in order to write a viable research fellowship or grant award application. The course will include topics on finding funding, grantsmanship, writing specific aims and research strategy sections, and addressing abstract, subjects protection, etc. A session on NRSA and other types of fellowships also will be provided. At the end of the course, participants should have completed key sections of their applications, ready for submission. Grading will be on a Satisfactory/Unsatisfactory system.

Prerequisites: None
Terms offered: II
Year offered: Annually
Hours per week: Lecture 2
Instructors: Thomas Green, Chih-ying Li

Biomedical Informatics: Applied Investigation and Analysis in Health Outcomes Research (INTD 6202)

This course provides an overview of topics, concepts, theories, and methods that form the foundations of medical informatics. This course focuses on integrating public and private EMR sharing platform that allows access to the network of more than 200 million patients worldwide, with roughly 38 billion clinical facts for conducting translational and clinical research. Lectures cover concepts such as data coding systems, data harmonization, data compliance/privacy regulations, basic epidemiology and statistics, patient-centricity (i.e., a cohort), and real-world evidence strategy and interpretation. In addition, the course emphasizes the importance of cohort selection, the development of retrospective cohort studies, and real-world medical record data utilizations. In addition to theoretical classes, laboratories use TriNetX platform access to allow students to implement and practice methods covered in the lectures recreating population studies and clinical trial protocols. This course aims to provide theoretical and practical experience in analyzing and interpreting real-world epidemiological data. The overall student performance is calculated based on the final presentation, quizzes on assigned readings, practical assignment completion, and participation in final project discussion.

Prerequisites: None
Terms offered: II
Year offered: Annually
Hours per week: Lecture 2
Instructor: Golovko, Khanipov

Experimental Pathology Course Descriptions

PATH Special Topics (PATH 6000)

Study of special topics in Experimental pathology. Topics are selected and study programs arranged on an individual basis with staff member.

Prerequisites: Consent of Instructor
Hours per week: Conference or discussion, 2
Terms offered: I, II, III
Year offered: Annually
Instructor: Staff

Research in Pathology (PATH 6097)

This course varies in credit according to the work performed. The student concentrates on a problem of his or her own choosing with faculty advisor.

Grading is S/U (satisfactory/unsatisfactory)
Prerequisite: None
Terms offered: I, II, III
Year offered: Annually
Instructor: McBride

Thesis (PATH 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Dissertation (PATH 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Biology of Arthropod Disease Vectors (PATH 6112)

The goal of this course is to introduce students to arthropods that are vectors for a wide variety of infectious agents that cause human diseases. The unique biology of hematophagous arthropods that has evolved to facilitate the coexistence between the vectors, pathogens, and the vertebrate host will be illustrated in both lectures and practical sessions. The curriculum will build upon a general introduction to arthropods. Then, using specific examples, the processes of infection, development, and transmission of pathogens will be discussed. This will include vector behaviors involved in location of the host, physiological adaptations to facilitate blood feeding and digestion, and factors that influence the vector-pathogen relationship. Options for controlling vector-borne diseases will be discussed from a historical perspective, with a consideration of how modern molecular approaches might be used in the future.

Prerequisites: None
Hours per week: 1
Terms offered: I
Year offered: Annually
Instructor: Bouyer/Vasilakis

Experimental Pathology Trainee Work in Progress (PATH 6115)

This course provides a forum for graduate student research in progress updates and is required for all graduate students in Experimental pathology. The objective of this course is to enable students to gain experience by orally presenting their current research and future studies, and responding to questions from the audience. Attendance is required at the weekly Experimental pathology seminars. Attendance at weekly pathology Grand Rounds, other weekly clinical conferences, interdepartmental infectious disease conferences, and immunology or toxicology seminar offerings I voluntary, but strongly encourages. Grading is Standard (A-F) and grades will be determined based on submission of written evaluations (2nd year), attendance, and completion of one annual research presentation. (The written evaluations must be turned in to the Program Coordinator within 1 week of the seminar. Evaluations submitted after 1 week will automatically be reduced by one grade and those submitted 2 weeks late will not be accepted or receive a grade of F.) Attendance at 90% of seminars is required for year 2 trainees, and 80% for trainees in years 3-5. However, it is strongly recommended that graduate students attend all trainee seminar series, particularly those of their fellow students. Grades in the third year and beyond are based on attendance. Attendance records for the trainee workshop are maintained by the Program Coordinator.

Prerequisites: Consent of program director
Hours per week: Conference 1
Terms offered: I, II
Year offered: Annually
Instructor: McBride

Clinical Microbiology Practicum (PATH 6123)

This course is designed to provide graduate students with an opportunity to gain both understanding and practical, hands-on experience in the policies, procedures and regulatory/safety standards of the clinical microbiology laboratory, and its role in infectious disease diagnostics. It serves as an introduction to the field of clinical microbiology, for those students interested in pursuing this area as a career choice. The student will rotate through different sections of the clinical microbiology laboratory. Bench-level rotations will expose the student to laboratory sub-specialties including bacteriology, virology, serology, mycology, mycobacteriology and parasitology. The student will be given simulated specimens on which to perform bacterial identification and susceptibility testing under the guidance of microbiology technologists. Throughout the rotation, students will participate in weekly Microbiology Plate Rounds and are encouraged to attend the weekly Adult and Pediatric Infectious Disease Case Conferences.

Grading is based on a written and oral assignment. Final grade will be assigned as either Satisfactory/Unsatisfactory (S/U)

Prerequisites: Consent of instructor
Hours per week: Conference or discussion 2
Lab, up to 30
Terms offered I, II, III
Year offered: Annually
Instructors: Williams-Bouyer/ Loeffelholz

Colloquium of Frontiers of Infectious Diseases and Tropical Medicine (PATH 6145)

Frontiers in Infectious Diseases is an Experimental pathology course that uses the Infectious Diseases and Immunity for its didactics. The colloquium is organized and sponsored by the Center for Biodefense and Emerging Infectious Diseases (CBEID), the Center for Tropical Diseases (CTD), and the Departments of Microbiology & Immunology (M&I) and pathology at UTMB. This colloquium was created to offer faculty, staff, and trainees the opportunity to hear about the latest research of recognized experts in the fields of infectious diseases, microbiology, and immunity. Invited speakers are almost always from academic institutions throughout the United States and occasionally from international institutions. The Colloquium offers a wide range of topics within the fields of infectious diseases, microbiology, and immunity, including epidemiology, vaccine development, pathogenesis, pathophysiology, molecular biology, cellular microbiology, etc. Students registered for this course will have the opportunity to meet the speaker in a separate small-group session called "meet the professor". This is a great opportunity to learn not only about the details of the speaker's research, but also about their motivations in science, their life experiences, and their advice as it relates to professional and academic advancement. Grading is S/U (satisfactory or unsatisfactory) and depends on attendance.

Specific requirements are the following: First year students will register for this course for the fall and spring semesters, and they must attend more than 80% of the seminars offered during those semesters
Second year students will register for this course for either the fall or the spring semester, and they must attend more than 80% of the seminars offered during the selected semester
Registered students must attend more than one third of the "meet the professor" post-seminar meetings
Terms offered: I,II
Year Offered: Annually
Instructor: McBride

Introduction to Vaccinology (PATH 6161)

Vaccines for the 21st Century is a five-week introductory course designed to provide the basic scientist with an understanding of vaccine development from conceptualization through development, testing and utilization. The course Objectives are to learn:

1. The history of the development of vaccines and their impact on society.
2. The identification of pathogens & diseases for which vaccines are needed.
3. The principles of the development, availability and use of vaccines.
4. The pathophysiologic approach to developing vaccine strategies.
5. The application of traditional and new technologies to vaccine development.
6. The importance of the regulatory process to vaccine development, including "proof of principle", pre-clinical and clinical testing.

The course will be taught in lecture format with a small number of expert lecturers. There will be assigned reading in preparation for each session. Reading materials will be provided. Each session will be 1 hour (total 15 contact hours). Course performance will be determined by take home midterm & final examinations (50% each).

Prerequisite: Consent of Instructor
Term offered: I
Year offered: Annually
Instructors: Milligan/Barnett

Workshop in Phylogenetics (PATH 6211)

Phylogenetic methods are becoming increasingly popular for studies of microbial systematics, molecular epidemiology and evolution, pathogen emergence, predicting host and vector relationships, inferring biochemical and drug sensitivity similarities, etc. Although user-friendly algorithms are now widely available, proper analyses require a theoretical understanding of the assumptions underlying the algorithms used, and the statistical methods for determining the stability of phylogenetic trees generated. This course is designed to provide students with a basic practical and theoretical knowledge of phylogenetic methods for analyzing nucleotide and amino acid sequences. Upon completion of the course, the student will be able to make sound decisions on the best methods for analyzing their own sequences, run a variety of algorithms on a UNIX workstation and Macintosh personal computer, and interpret results to reach valid, statistically-supported conclusions.

The course will meet for one session of two hours each week. The first hour will be devoted to theoretical discussions of methods, and demonstrations using a laptop computer and projection system. The second hour will be a computer laboratory session where students will be given hands-on training with phylogenetic algorithms. Grading is S/U (satisfactory/unsatisfactory) and based on a class project involving phylogenetic analysis of the students' sequences (either their own sequences from a research project or GenBank sequences of interest) as well as completion of a mock research paper suitable for submission to a journal. The results of class projects will also be presented to the class in typical scientific meeting format. Requirements for a passing grade include both publication quality data and writing, and a presentation of quality suitable for a national meeting. The final grade will be based 75% on the written class project (mock research paper) and 25% on the oral class presentation.

Prerequisites: Consent of Instructor
Hours per week: 2
Term offered: I
Year Offered: Annually
Instructor: Forrester

Basic Human Pathobiology-Toxicology (PATH 6276)

The objective of this course is to introduce the principles of toxicology. This is achieved by presenting specific clinically-relevant examples of toxic injury and exploring the biochemical, cellular and Pathogenetic mechanisms that underlie these examples. Mechanisms of toxin-induced cellular injury discussed could include injury by reactive oxygen and nitrogen species, xenobiotic adduction and metabolism, and receptor/signal disruption. Grading is based on contributions to class discussion (40%) and a final examination (60%).

Grading is Standard (A-F)
Hours per week: Lecture I, Conference I
Term offered: II
Year offered: Annually
Instructors: Boor/Khan

Introduction to Competitive Grant Writing (PATH 6279)

This course will provide an introductory and interactive experience to competitive grant writing. Topics to be covered include understanding the review process, and planning, organizing, writing a successful hypothesis driven application. Students will be required to write a two year grant application, provide written critiques, and participate in a final mock study section review. Grading is Standard (A-F) and will be based on class participation (30%), written assignments (40%), and quality of the final application (40%).

Prerequisites: Consent of Instructor
Term offered: I
Year offered: Annually
Instructor: Dr. Vasilakis

Cellular Microbiology & Disease (PATH 6289)

This advanced course provides as in-depth examination of the molecular mechanisms of host-bacterial interactions to understand the bacterial strategies for evading or surviving the host defense systems. All topics are conceptual overviews of the principal mechanisms of bacterial pathogenesis. Topics include molecular mechanisms of bacterial adherence to host cells and bacterial signaling host cells through adhesion molecules, bacterial subversion of endocytic pathways, bacterial manipulation of the host cell cytoskeleton, bacterial secretion systems, immune evasion mechanisms and persistent infection, and bacterial genomes and reductive evolution. Emphasis is given to diseases with prototypic pathogenic mechanisms. Instruction involves lectures, class discussions and readings in contemporary or classic literature. Grading is based on attendance (20%), class discussions and participation (30%), and one final examination (50%). The format of final exam will be for students to choose 5-6 out of 10-12 questions.

Grading is Standard (A-F)
Hours per week: Lecture 4, Conference 1
Term offered: II
Year offered: Annually
Instructors: Dr. Aguilar, Dr. Sahni

Tropical Diseases (PATH 6318)

This course is designed to provide graduate students with an overview of tropical diseases and related current research. The course is not designed to be comprehensive, but will sample representatives of major infectious tropical diseases. Emphasis is placed on the ecology, epidemiology and control of tropical diseases. The class meets two (2) times a week for 90 minutes; each session includes a 45 minute lecture by a faculty member, followed by the presentation of a pertinent paper and discussion questions. Students are expected to submit their selected reference and at least 5 discussion questions to the lecturer one week in advance.

Grading is Standard (A-F)
Prerequisites: Consent of instructor
Hours per week: Lecture 3
Term offered: II
Year offered: Annually
Instructors: Dr. Melby, Dr. Travi

Basic Human Pathobiology (PATH 6386)

This 8-week course will provide a fundamental background for students who are interested in pursuing knowledge in infectious disease pathogenesis and histopathology. This course will include a series of lectures on bacterial and viral pathogenesis and histopathology. Bacterial pathogens include the agents of tuberculosis, plague, rickettsioses/ehrlichioses, and anthrax. Viral pathogens include alphaviruses, herpes viruses, hepatitis viruses, viral hemorrhagic fever viruses, Zika, and Influenza. Introductory lectures in immunology will include cellular and humoral immunity, cytokines and principles of immunopathology. Additional introductory lectures include animal models of infectious diseases and diagnostic principles of infectious diseases in the clinical microbiology laboratory (including molecular diagnostics). Each pathogen lecture will have a component of molecular pathogenesis followed by a discussion of its histopathology.

Prerequisites: None
Hours per week: 1.5
Term offered: III
Year offered: Annually
Instructors: Dr. Olano

Functional Histology and Pathobiology (PATH 6436)

This 16-week course will provide a fundamental background for students who are interested in pursuing experimental pathology. This course will include, but is not limited to, general pathobiology, basic functional histology, and organ development of humans. Pathobiology topics will include cell injury/death, acute inflammation, immunopathology, neoplasia, coagulation, and genetic diseases. Functional histology will include the following organ systems: cardiovascular, respiratory, nervous, hematopoietic, gastrointestinal/hepatic, and urinary. For each system, normal functional histology and the main categories of diseases will be discussed (infectious, neoplastic, environmental, hemodynamic, etc.). Supplemental lectures on experimental techniques used in pathology research will also be included: histology/immunohistochemistry, electron microscopy, flow cytometry, and laser capture microdissection. Topics will be discussed as didactic lectures and use of glass slides/virtual imaging for demonstration of histology slides. Seven journal club sessions will take place during the course and will be related to the topics discussed during the course. Grading is Standard (A-F) and will be based on two mid-term exams and one final exam. Participation during journal clubs will also be graded. (Examinations: 20% + 20% + 20%; Journal Club: 20%; Attendance: 20%.

Prerequisites: Consent of instructor
Hours per week: Lecture 4
Term offered: II
Year offered: Annually
Course Director: Dr. Olano

MD/PHD Course Descriptions

MD/PhD Lab Rotation (MDPH 6001)

The objectives of this course are to provide students an opportunity to become familiar with the faculty and their research efforts in the graduate school by participating in the activities of the lab and by becoming acquainted with the lab staff and the goals of the research project. Letter grades will be determined by the instructor and will be based on lab performance. Course taken during the summers prior to year 1, 2, and 3 (optional).

Term offered: Summer
Year offered: Annually
Prerequisites: Enrolled as a student in the MD-PhD program and not yet enrolled in a specific graduate program
Course Instructor: Michael Laposata

Current Topics in Pathobiology and Host Defense Course (MDPH 6102)

This course is designed to supplement the medical school pathobiology and host defense block. Students will meet weekly to review current literature related to disease pathogenesis covered in the medical school. Students will be graded (letter grades) on class performance and attendance. Course taken in spring term of year 1.

Term offered: Spring
Year offered: Annually
Prerequisites: Prior or concurrent enrollment in Pathobiology (IMC 1210)
Course Instructor: Michael Laposata

MD/PhD Seminar (MDPH 6101)

The seminar program focuses on research activities in various graduate programs and other topics of interest to MD-PhD students. Grading is determined on a pass (satisfactory)/fail basis, based on participation/attendance. Course taken during the fall and spring semesters for the duration of the program.

Terms offered: Fall; Spring
Year offered: Annually
Prerequisites: Enrolled as a student in the MD-PhD program
Course instructor:

Current Topics in Neuroscience and Human Behavior Course (MDPH 6202)

This course is designed to supplement the medical school neuroscience course. Students will meet weekly to review current literature related to neuroscience covered in the medical school. Students will be graded (letter grades) based on class performance and attendance. Course taken in spring term of year 1.

Term offered: Spring
Year offered: Annually
Prerequisites: Prior or concurrent enrollment in Neuroscience and Human Behavior (IMC 1220)
Course Instructor: Michael Laposata

Current Topics in Molecules, Cells and Tissues Course (MDPH 6203)

This course is designed to supplement the medical school molecules, cells, and tissues block. Students will meet weekly to review current literature related to the molecular mechanisms of diseases covered in the medical school. Students will be graded (letter grades) on class performance and attendance. Course taken in fall term of year 1.

Term offered: Fall
Year offered: Annually
Prerequisites: Prior or concurrent enrollment in Molecules, Cells and Tissues (IMC 1120)
Course Instructor: Michael Laposata

Microbiology & Immunology Course Descriptions

International Internships in Vaccinology (MICR 6070)

The Sealy Center for Vaccine Development (SCVD), in conjunction with the World Health Organization (WHO) headquarters, sponsors an annual internship program. The traveling internship program will form the basis for this course. Students participating in this course will undertake an internship at the World Health Organization Headquarters in Geneva, Switzerland. Each student will be paired up with a mentor at WHO and a UTMB SCVD member to work on a defined project related to public health and vaccines for a period of 3 months (typically from early Spring to Fall of each year, with specific time-frames to be determined for each internship). Each internship project will involve significant contribution to a team tasked with developing a report on vaccines and a specific infectious disease for the WHO.

Grading (satisfactory/unsatisfactory) will be based on participation, attendance, completion of assigned task(s), evaluations/feedback received from WHO and UTMB mentor(s), and submission of a final report to the SCVD by the student summarizing their internship experience and outcomes.

Artificial Intelligence (AI)

All work submitted in this course is to be done entirely by students. This includes all process work, drafts, and final works, whether in group or individual work. The following are violations of academic honesty: using generative AI tools such as ChatGPT, Scite.ai, Jenni.ai, having other people or entities do any portion of a graded assignment, whether for hire or not.

Prerequisites: Students must have completed all required graduate program coursework and entered candidacy prior to commencing the internship. Written approval from the mentor is also required.
Term offered: I, II, III
Year offered: Annually
Hours per week: Variable

Field Experience in OneHealth and Outbreak Response (MICR 6071)

OneHealth is defined as the collaborative effort of multiple disciplines -working locally, nationally, and globally -to attain optimal health for people, animals, and our environment. Implementing this approach requires braking down professional silos and engaging medical and veterinary professionals, laboratory scientists, the public health community, policymakers, and experts from the biomedical, social. and environmental sciences. This 4 week course will take a OneHealth approach to the problem of emerging infectious diseases, from the veterinary, public health, laboratory, and clinical points of view. Using innovative and highly inter-professional learning approaches and guided by experts in the field, students will travel between Texas A&M University, UT Rio Grande Valley, and UTMB to observe regional differences in the social. economic, cultural, and environmental determinants of population health. Topics that will be addressed include animal/veterinary health, vector dynamics, sample collection and processing, molecular diagnostics, countermeasure development, biocontainment/biosecurity, clinical management of potential infectious threats, communication skills, interprofessional teamwork, and public health system response. Students must complete an application process and undergo selection to participate in this course. Grading (satisfactory/unsatisfactory) will be based on attendance and participation in assigned activities at each field site, completion of assigned task(s), evaluations/feedback from the course mentors, and submission of a final report to the course committee by the student.

Prerequisites: Must have completed all required graduate coursework and have passed the qualifying exam. Written approval from the student’s dissertation mentor is also required.
Term offered: III
Year offered: Annually
Hours per week: Variable

Research (MICR 6097)

Formal research directed toward Masters Doctor of Philosophy degree programs. Grading will be based upon the student's level of performance as reported by the student's research supervisor and will be assigned as satisfactory or unsatisfactory.

Prerequisites: Admission to the microbiology and immunology program.
Term offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 3-27

Thesis (MICR 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Dissertation (MICR 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Training in Infectious Disease Outbreak Response (MICR 6140)

This 3-day course in infectious diseases provides the students with the opportunity to test their own knowledge in solving an outbreak scenario, and to learn how institutions such as the Centers for Disease Control approach infectious disease outbreaks. In this three-day course students will be confronted and led through a fictive outbreak simulation. Using innovative and highly inter-professional learning approaches and guided by experts in the field, students will understand the steps required in an outbreak response; solve the etiology of the outbreak agent case by drawing on their previously acquired knowledge and skills in virology, immunology, bacteriology, and epidemiology; and learn how to interact with the public. Topics that will be included are sample collection and processing, diagnostic tool and immuno reagent development, countermeasure development, and public outreach. Grades will be satisfactory (S) or unsatisfactory (U) based on participation. A grade of satisfactory will depend on: a) attendance of the student to all scheduled sessions and discussions; b) a short report during the course; and c) writing one -page reflective paper that will serve as self-evaluation.

Prerequisites: Must have taken MICR 6403 – General Virology, MICR 6315 – Pathogenic Bacteriology, or MICR 6408 – Advanced Immunology.
Term offered: III
Year offered: Annually
Hours per week: Lecture 6, Conference 18

Student Research Update Seminar (MICR 6142)

Weekly student research update seminars for Microbiology and Immunology graduate students to present their current work. Students and faculty are invited and give the presenting student an opportunity for helpful critique and suggestions regarding their thesis project. A summary report is provided to the presenter and mentor(s) with feedback received from all attendants.

Artificial Intelligence (AI)

All work submitted in this course is to be done entirely by students. This includes all process work, drafts, and final works, whether in group or individual work. The following are violations of academic honesty: using generative AI tools such as ChatGPT, Scite.ai, Jenni.ai, having other people or entities do any portion of a graded assignment, whether for hire or not.

Prerequisites: Student must have declared Microbiology & Immunology as their graduate program
Term offered: I, II
Year offered: Annually
Hours per week: 1- Seminar
Detailed Course Information (PDF)

Internship in Vaccinology (MICR 6143)

The Sealy Center for Vaccine Development(SCVD), in conjunction with the World Health Organization(WHO) headquarters, sponsors an annual Internship program. The proposed course will be associated with a UTMB-based Internship program that will involve preparation of a report by the student on a specific infectious diseases and vaccines topic, intended for use as a briefing document by a WHO expert committee. The student will work as part of a small group (2-3 students) under the supervision of a SCVD member. The internship will be conducted over a 3 month period, concurrent with the trainee's regular educational and research activities. Grading will be based on participation, attendance, effective performance of assigned tasks, evaluations/feedback received from mentors, and submission of a final report to the SCVD by the intern summarizing their internship experience and outcomes. Prerequisite: Consent to be enrolled required.

Artificial Intelligence (AI)

All work submitted in this course is to be done entirely by students. This includes all process work, drafts, and final works, whether in group or individual work. The following are violations of academic honesty: using generative AI tools such as ChatGPT, Scite.ai, Jenni.ai, having other people or entities do any portion of a graded assignment, whether for hire or not.

Prerequisites: For graduate students, successful applicants must have completed all required BBSC and/or program coursework prior to commencing the internship. Written approval from the mentor is also required.
Term offered: I, II, III
Year offered: Annually
Hours per week: 2 - Conference or Discussion

Current Topics in Infectious Diseases and Immunity (MICR 6195)

Seminar course intended to familiarize students with current research in the areas of infectious diseases and immunology. Students attend weekly seminars in the Infectious Diseases and Immunity Colloquium. Students may substitute some seminars in the series with presentations from the monthly Immunology Research in Progress series. Students are required to enroll during the first two years in the program. Each student will be assigned a session per term to lead class by discussing an assigned topic relevant to a journal club article. Students will also participate in small group discussions and prepare essays. Grading will be based on attendance (30%), preparation and discussion leadership (20%), and reflective essays or review essay (50%).

Artificial Intelligence (AI)

All work submitted in this course is to be done entirely by students. This includes all process work, drafts, and final works, whether in group or individual work. The following are violations of academic honesty: using generative AI tools such as ChatGPT, Scite.ai, Jenni.ai, having other people or entities do any portion of a graded assignment, whether for hire or not.

Prerequisites: None
Term offered: I, II
Year offered: Annually
Hours per week: 1 - Conference or Discussion

Scientific Writing & Grant Proposal Preparation (MICR 6255)

This course introduces the principles of scientific writing and grant proposal preparation in the new NIH format. The goal of this course is to familiarize students with the individual parts of an NIH-style grant application, to help students in acquiring scientific writing skills, and to prepare students for the qualifying exam in the Microbiology & Immunology graduate program. It consists of weekly lectures and small-group sessions during which experienced faculty mentors present didactic instruction on planning, organizing, and writing a hypothesis-driven grant application. Students will also work individually and in small groups on an original grant proposal. Students write a grant proposal with precise deadlines for submission of individual parts. Grading will be based on the assignments (30%), the final grant application (50%), and an oral defense of the proposal (20%).

Prerequisites: None
Term offered: III
Year offered: Annually
Hours per week: 2

Pathogenic Bacteriology (MICR 6315)

The objective of this course is to introduce students to concepts of research on bacterial pathogens. Pathogens infecting man will be studied, with emphasis given to their pathogenic mechanisms, induction of immunity, and physiochemical characteristics. The course will consist of lectures and discussions. Grading based on written examinations.

Prerequisites: BBSC first year curriculum
Term offered: III
Year offered: Annually
Hours per week: Lecture 2; Conference or discussion 1

General Virology (MICR 6403)

Principles and concepts of animal virology will be presented, but the majority of the course will be devoted to the study of viruses of medical importance. Emphasis will be placed upon the chemical and physical characteristics of viruses, viral interaction with the immune system, pathogenesis of viral infections, and the mechanisms of replication of viruses. The course consists of lectures and discussion periods. Grades will be based on performance on written examinations.

Prerequisites: BBSC First Year Curriculum
Term offered: I
Year offered: Annually
Hours per week: Lecture 3; Conference 1

Advanced Immunology (MICR 6408)

An in-depth study of the immune response and related events with emphasis on the mechanism of cellular and humoral immunity. Some of the topics to be covered include antibody structure and function, antigen-antibody reactions, cells involved in the immune response, antibody formation, cellular immunity, mediators, tolerance, and immunogenetics. Material will be presented in lectures and assigned readings of texts, reviews, and research articles. Grading will be based on written examinations and class participation.

Artificial Intelligence (AI)

All work submitted in this course is to be done entirely by students. This includes all process work, drafts, and final works, whether in group or individual work. The following are violations of academic honesty: using generative AI tools such as ChatGPT, Scite.ai, Jenni.ai, having other people or entities do any portion of a graded assignment, whether for hire or not.

Prerequisites: BBSC First Year Curriculum
Conference or discussion 1
Term offered: II
Year offered: Annually
Hours per week: Lecture 3
Course Coordinators: Soong/Milligan

Masters of Medical Science Course Descriptions

Research (MMSC 6097)**

This course initiates the formal research training directed toward a Masters of Medical Science degree. During this course, the student will select a supervisory committee, submit full written proposal for approval, orally defend the approved written proposal, and request admission to candidacy. Grading is based on the student's level of performance as satisfactory, needs improvement, or unsatisfactory.

Credits: 3-10
Course grades: Satisfactory or Unsatisfactory (S/U)
Term offered: I, II, III
Year offered: Annually

Thesis (MMSC 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Reproductive Biology Journal Club (MMSC 6105)

This longitudinal course spans across two terms. It will improve the knowledge of research methodology in

reproductive biology and provide the improvement for clinical practice by latest research. This course will develop abilities to critically analyze the research article and improve critical appraisal skills.

By participating the journal clubs through presentations and by completing the readings, the students will be able: To enhance the current state of knowledge regarding the research in the OB-GYN fields. Experience in reviewing and critiquing research articles. Each journal club will lead by different student for discussion by writing a blog that critically evaluates peer-reviewed science articles for subsequent group discussion threads that reinforces those principles of various research approaches and analytical methods.

Journal clubs will also help students to develop their scientific inquiry and written skill sets. A grade of “G” (course in progress) will be assigned at the end of the Fall term, and a single, 1-hour course grade will be assigned at the end of the Spring. Grades will be based on the performance of an examination, written report, and an oral presentation.

Seminar (MMSC 6195)

This course is to expose students to a wide range of current biomedical research topics. All Masters of Medical Science students must register for seminar courses every term offered irrespective of status in program. Students may attend a seminar on campus or specific specialty-specific topics at national meetings to fulfill this requirement.

The course spans across two consecutive terms, Fall and Spring. A grade of "G" (longitudinal} will be assigned at the end of the Fall term. The final course grade will be assigned at the end of the Spring term.

Students are required to attend a total 16 seminars over the two terms with a total of 8 completed for each term and complete an online evaluation for each seminar. Grading will be Satisfactory(S)/Unsatisfactory (U) or, Needs Improvement (N) based on attendance.

Reproductive and Perinatal Pharmacology (MMSC 6201)

This course will describe the challenges associated with the administration of medication during pregnancy and breastfeeding. Students will be introduced to basic pharmacokinetic and pharmacological principles, followed by descriptions of how physiological changes associated with pregnancy can affect drug efficacy.

Lectures will also cover mechanisms of drug transfer across the placenta and mammary glands, ethics of clinical research during pregnancy, fetal drug therapy, mechanisms of action for drugs prescribed for assisted reproductive technology, and pharmacogenomics. Clinical examples for various drug classes will be presented. Each student (or student pairs, depending on enrollment) will select a class of drugs to focus on-including both therapeutic drugs and drugs of abuse-and will take turns giving a 30 minute presentation to report on the drugs' mechanisms of action, side effects, special considerations for use during pregnancy and lactation, and a clinical case report from the literature. The students will also submit a written report on their selected drug class, following a provided template. Another grading component is an exam.

Neuroscience Graduate Program Course Descriptions

Information About the Course of Study

Expand All

A. Course Requirements

Students in the Neuroscience Graduate Program will take the integrated first-year Basic Biomedical Sciences Curriculum (BBSC). In addition, a series of required and elective courses specific to the NGP are taken in the first and subsequent years. These include the courses Integrative Neuroscience (NEUR 6403), Teaching in Neuroscience (NEUR 6220) and Neuronal Excitability (NEUR 6207). Neuroscience students must take any combination of available electives for a minimum of 6 credit hours. Students are required to take a minimum of 9 credit-hours per term (The second number in each 4-number course identification code represents the credit hours for the course). Course evaluations by students are required for all didactic courses in the program. Grades will not be released for any course until all evaluations are received.
B. Minimal Performance Criteria

Students in the Neuroscience Graduate Program should maintain a grade of B or higher in all required courses of the program. Students who fail to do so will be required to make up the deficiency by a variety of means, including but not limited to, retaking examinations, taking a readings or special topics course, or repeating the course the next time it is offered. The remedial action to be utilized will be determined by the Advisory Committee and Program Director. Rules and requirements regarding probation and dismissal from the graduate school may be found in section 4.57 of the Academic Policies of the Graduate School of Biomedical Sciences.
C. Elective Courses

1. Students may choose elective courses to strengthen special areas of interest or weakness, or to provide background for research skills. A minimum of 6 credit hours of elective courses is required in any combination. Students may take additional hours if appropriate.

2. The elective courses available include any of the courses shown on the chart. Courses offered by other graduate programs may be taken in lieu of the electives listed, but approval of the Program Director is required for the substitution.
D. Laboratory Rotations

1. New students will meet with the NGP Program Director and Advisory Committee, who will introduce them to the research activities of our Program.

2. Each student will rotate through at least 2 laboratories of his/her choice during the first (BBSC) year, beginning with the fall term. Registration is for BBSC 6042 Lab Rotations. NGP students then register for lab rotation in the neuroscience program (NEUR 6042) in the lab they chose to join by the end of the BBSC year and continue to register for NEUR 6042 each term until they pass the written qualifying examination and enter into "Research". Credit hours depend on the time commitment of the student and faculty member but may not be for less than 3 credit hours (9 contact hours per week) per term.
E. Seminars

Each student is required to register for Seminar each term for the duration of his/her tenure in the graduate school. All students registered for the NGP seminar course (NEUR 6195) must attend at least 80% of fourteen Program-recommended seminars in each term (approximately one seminar per week). Regular and student seminars count toward satisfying the 14-seminar requirement. "Regular" seminars are those presented by non-students (local or visiting faculty, scientists, etc.). "Student" seminars are those presented by any NGP student and include conventional seminars or progress reports as well as defenses of dissertation proposals and dissertations.

In addition to the seminar attendance requirements, each student must write a brief statement about the seminar, summarizing in the style of NIH reviews (1) Overall impact of the work described in the seminar, and (2) Innovation. Students are graded S/U for the written summary (Form E in our Program Policies). Summaries will be reviewed/graded by the Director of the NGP seminar course (NEUR 6195).

Each student will also present one seminar each year of the neuroscience program, typically in the summer term, including the dissertation proposal, the dissertation defense, and other annual presentations. The Advisory Committee is responsible for running the seminar program for students. Two successful seminar series, the Mitchell Center for Neurodegenerative Diseases Seminars and the Neuroscience & Cell Biology Departmental Seminars are offered, which provide our students with exciting opportunities to interact with external speakers and UTMB faculty and enjoy important presentations by students and postdoctoral fellows as well.

In addition to regular seminars, we are fortunate to be able to offer the James E. Beall II Memorial Lecture, which is co-sponsored by the Neuroscience Graduate Program and the Department of Neuroscience & Cell Biology and is given annually by distinguished investigators in the neurosciences.

Laboratory Rotations (NEUR 6042)

The objectives of this required course are to provide students an opportunity to become familiar with the faculty and their research efforts in the Neuroscience Program by participating in the activities of the laboratory (gaining supervised, hands-on experience with techniques and experimental protocols) and by becoming acquainted with the laboratory staff and the goals of the research project. Students will be taught by discussions with the instructor, by reading relevant literature and by active participation in laboratory procedures. The long-term goal of this course is to provide exposure to a variety of experimental approaches and to help in the identification of a supervisory professor and dissertation project. Neuroscience Program students are required to spend at least 3 credit hours in each of three different laboratories (that is, do three different rotations), and must complete the three rotations before the end of their fifth term in the program. Grading is A, B, C, F and based on participation in lab discussions and experiments.

3-8 credits
Term offered: Fall, Spring, Summer
Year offered: Annually
Hours per week: Laboratory, 9-24 (variable)
Instructors: Staff

Research (NEUR 6097)

Formal research directed toward development of the dissertation research for the Doctor of Philosophy degree. Grading will be based upon the student's level of performance as reported by the student's research supervisor and will be assigned as satisfactory or unsatisfactory.

Prerequisites: Admission to a research group by a mentor
1-8 Credits
Term offered: Fall, Spring, Summer
Year offered: Annually

Dissertation (NEUR 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).

Prerequisites: Admission to candidacy
Terms offered: Fall, Spring, Summer
Year Offered: Annually
Hours per week: Variable 3-9

Cellular Signaling in Neurodegeneration (NEUR 6122)

The focus of this course is on those molecular and cellular events involved in neuronal dysfunction/death during neurodegenerative disorders. Emphasis is put on signaling pathways initiated by misfolded proteins and their toxic oligomers impacting neuron/glia physiology and function from both the extracellular and intracellular compartments, including synapses, receptors, calcium signaling/homeostasis, gene expression. Additional topics are cell signaling events induced or disrupted by reactive oxygen/nitrogen species and their impact on mitochondrial and synaptic function as well as on neural cell physiology. Neural stem cells and disruption of proliferative signaling during neurodegenerative diseases is also included. Grades will be based on the student’s leadership in assigned paper discussions, report on published paper and attendance.

1 credit
Term Offered: Spring (1st 8 weeks)
Year offered: Annually
Hours per week: Lecture, 2
Course Directors: Giulio Taglialatela, PhD and Agenor Limon, PhD

Biochemistry and Biophysics of Amyloid Proteins (NEUR 6123)

This course will discuss and examine the theoretical basis for biochemical and biophysical methods used to study, all forms of amyloid, fibrils, oligomers, amorphous aggregates and amyloid strains, e.g. size exclusion chromatography, electron microscopy, X-ray diffraction fluorescence based assays, immunological assays, solution biophysics, X-ray diffraction and others used to study protein different aggregates. In addition, the students will learn how these methods are collectively used to perform comprehensive analyses of stable and intermediate amyloid structures formed by nucleation and aggregation assays. Grades will be based on the student’s leadership in assigned paper discussions, report on published paper and attendance.

1 credit
Term Offered: Spring (2nd 8 weeks)
Year offered: Annually
Hours per week: Lecture, 2
Course Director: Rakez Kayed, PhD

Neurobiology of Disease I (NEUR 6181): Proteinaceous Deposits in Dementias and Beyond

This course will explore the mechanisms, nature and neurobiology of proteinaceous deposits in protein misfolding diseases, including dementias. Other courses in this sequence will address other mechanisms and diseases of the nervous system. The course will meet once per week and will consist of 1 hour lecture followed by 1 hour faculty-lead discussions of recent literature related to the topic. The introductory lecture will initiate each topic, but successive classes will consist of student-generated discussion of assigned papers from the literature. Grades will be assigned based on student participation. This sequence of Neurobiology of Disease (NOD) courses is designed for students in the Neurobiology of Disease track and the Neuroscience Graduate Program, for MD-PhD students in neuroscience, and for any other graduate student interested in neurobiological diseases.

1 credit
Prerequisite: None
Term offered: Spring
Year offered: Annually
Hours per week: Lecture 1, Discussion 1
Course Director: Dr. Rakez Kayed

Neurobiology of Disease IV (NEUR 6184): Neurobiology in retinal disease

This course will explore the nature and basic mechanisms of neurobiological diseases related to ophthalmic/retinal diseases. The retina is an extension of the brain and has been recognized as a "window" of the brain. This course is to introduce retinal neurobiology in the context of major retinal diseases that lead to blindness and to discuss the potential association between neurological changes in the retina and brain diseases. Other courses in this sequence will address other diseases of the nervous system. The course will meet once per week and will consist of faculty-led discussions, lectures, paper reading and discussion. Evaluation will be based on attendance and active participation. Students will be graded based on the quality of their presentation and their ability to lead and contribute to classroom discussions. Grading system is standard A-F.

1 credit
Prerequisite: None
Term offered: Spring
Hours per week: Lecture 1, Discussion 1
Course Directors: Dr. Hua Liu and Dr. Praveena Gupta

Seminar (NEUR 6195)

The objectives of this course are to: 1) expose the students to a wide range of current topics in neuroscience, and 2) provide the students with experience in organizing and presenting seminars. Exposure to current topics in neuroscience will be accomplished by requiring students, who have not advanced to candidacy, to attend 14 seminars presented by GSBS students, and by local and visiting scientists. Experience in organizing and presenting seminars will be obtained by requiring students in candidacy to organize and present a seminar each year. The students will present literature and experimental data related to their research experiences. Their performance will be evaluated by their Supervisory Committee members. Student attendance is mandatory for Neuroscience program seminars and for the annual student symposium. Active participation by asking questions is encouraged.

1 credit
Term offered: Fall, Spring, Summer (Required every term student is enrolled
Year offered: Annually
Hours per week: Seminar, 2
Course Director: Ping Wu, MD, PhD

Neuronal Excitability (NEUR 6207)

This 8 week course deals with fundamental concepts that underlie electrical excitability, conduction or electrical activity and presynaptic mechanisms. Topics covered include electrochemical potentials, properties of voltage-gated channels, electrotonic spread vs. propagated activity, regulation of exocytosis, quantal analysis of transmitter release and analytical techniques including current and voltage clamp, single channel recording and noise analysis. The class will be presented as lectures with student discussion. Grades will be based on class participation and examinations.

2 credits
Prerequisites: BBSC 6302 Cell Biology and BBSC 6303 Biochemistry or consent of instructor
Term Offered: Spring (1st 8 weeks)
Year offered: Annually
Hours per week: Lecture, 3; Discussion, 1
Course Director: Dr. Owen Hamill

Teaching in Neuroscience (NEUR 6220)

The objective of this course is to provide students with an opportunity to gain experience in medical school teaching, as well as enhance their knowledge of neuroanatomy. Students will participate in teaching and discussion in the laboratories of the Neuroscience and Human Behavior (NHB) course which is offered to the UTMB first year medical students each spring semester. The students participate in hands-on demonstration/dissection of human brain samples in five two-hour wet laboratory sessions, working along-side UTMB faculty lab instructors. In each lab the NGP students will review a “hit list” of critical brain structures by interacting with the students grouped as 5 students at each anatomy lab tank. In addition, after the final wet lab session the students run a two-hour interactive session in which they present the whole student body with review questions (i.e., using the Poll Everywhere APP) on the neuroanatomy/neuropathology of the human brain, explaining in detail the basis of the correct answers and answering any student queries. Grading will be based on knowledge of material, ability to present reviews to class clearly, ability to interact effectively with small groups in lab, and participation in preparatory sessions and demonstrations.

2 credits
Prerequisite: NEUR 6403, or consent of instructor
Term offered: Spring (2^nd 8 weeks)
Year offered: Annually
Hours per week: Lab - 4; Discussion, 1
Course Director: Dr. Owen Hamill

Neuroscience of Infectious Disease (NEUR 6226)

Sequelae are defined as a condition resultant of disease, typically a chronic complication of an acute illness. Neurological sequelae are those complications involving the brain and central nervous system and can include intellectual disability, seizures, emotional instability, vision loss, and hearing loss. Although many infections may lead to sequelae, the related pathology and the mechanisms associated with sequelae have not been fully identified. Recent outbreaks of Ebola and Zika virus have further exemplified the need for models to study the development of these conditions.

a) The objective of this course is to provide an overview of the immune response to viruses, bacteria and parasites, the neuroimmune response, neuroanatomy, CNS structural and functional domains, the blood brain barrier, and examples of viral, bacterial, and parasitic encephalopathies with particular focus on route of entry to the CNS (if known), specific neuroimmune responses (if known), and susceptible brain regions (if known). b) Teaching techniques to be employed will be didactic lectures and journal club presentations c) Methods of evaluation will be a 1) final exam, 2) journal club presentation d) Basis for grading will be 1) class participation, 2) in-class exams, 3) attendance, 4) journal club presentation.

2 credits
Prerequisite: None
Term offered: Spring
Hours per week: 2
Course Directors: Dr. Kelly Dineley, Dr. Irma Cisneros

Nursing Graduate Program Course Descriptions

Independent Study (GNRS 6088)

Detailed or in-depth study in a specific topic area. Topic and mode of study are agreed upon by student(s) and instructor. May be repeated when topics vary.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor. A course plan must be completed, signed by both the faculty and the student, and submitted to and approved by the Nursing PhD program director.
Terms offered: I, II, III
Year offered: Annually
Hours per week: Variable

Research (GNRS 6097)

Formal research directed toward completion of the Doctor of Philosophy degree. The student will develop a research proposal on a topic of his or her own choosing with faculty advice.

Prerequisites: Completion of required course work
Term offered: I, II, III
Year offered: Annually
Hours per week: Variable

Thesis (GNRS 6098)

Once admitted to candidacy, it is required for students pursuing a Master of Science or Master of Arts degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the thesis for the Master of Science or Master of Arts degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student’s level of performance as reported by the chairperson of the student’s supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Dissertation (GNRS 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Doctoral Research Seminar (GNRS 6340)

This course is designed for students who are initiating candidacy for the doctoral degree. Participants present their proposals for research in nursing. Emphasis is placed on collegial exchange and shared learning through analysis and critique. Evaluation of student progress is based on presentation and participation.

Prerequisites: Admission to candidacy for the Nursing PhD Program
Term offered: I,II,III
Year Offered: Annually
Hours per week: Seminar 3
Instructor: Dr. Darlene Martin

History and Philosophy of Science in Nursing (GNRS 6341)

This course focuses on the study of the history and scope of knowledge in the science of health promotion, human response, and healing and its relationship to nursing science. Epistemological assumptions, theoretical explanations, empiricism, intervention, and social outcomes will be explored. Diverse ways of knowing will be contrasted with the processes of scientific discovery. Evaluation of student progress is based on seminar participation, science paper, and final exam.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: I
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Darlene Martin

Qualitative Research Methods (GNRS 6348)

This course guides students in developing knowledge and skills required for the conduct of qualitative investigations that seek to elicit subjective interpretations of health, healing, and human response phenomena from persons who know and live with them. Selected research approaches and their philosophical and epistemological traditions are explored and critiqued for their usefulness in revealing rich descriptions of contexts, experiences, and meanings. Theoretical, ethical and practical issues are critically analyzed in the context of knowledge development, trustworthiness, diffusion, utilization, and evaluation. Evaluation of student progress is based on course participation, critiques, interpretive exercise, written first draft of proposal and presentations.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor; GNRS 6341, 6400
Term offered: I
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Carolyn Phillips

Survey of Instrumentation Methods (GNRS 6352)

The course provides a study of the theories and methods of instrument development and psychometric assessment applied to nursing. The basic psychometric properties to be assessed and methods to apply them in advance of conducting research are explored. Evaluation of student progress is based on preparation of expert panel review, writing assignments, and objective exam.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: I
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Sheryl Bishop

Nursing Science I (GNRS 6357)

This course emphasizes theories and research related to health promotion, human response, and healing. The analysis, critical evaluation, and interpretation of research in these areas provide students with the foundation to explore original ideas for the purpose of generating nursing knowledge. Theories and related research will be presented and discussed. Students will delineate areas of research interest consistent with the course foci. Evaluation is based on papers, class presentations, and class participation.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: I
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Mary O’Keefe

Pedagogy: Teaching, Research and Scholarship in the Clinical Environment (GNRS 6362)

This course explores the interplay of scholarship, pedagogy and clinical expertise in the patient care environment. Students’ self-assessments will determine the specific clinical populations and care environments where they will participate in selected clinical learning experiences and guided readings. Emphasis also is placed on student’s exploration of the clinical and research literature related to the selected patient population, identification of researchable questions related to that patient population and the ramifications of teaching students within the unique clinical venue.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: I, II, III
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Carolyn Phillips

Advanced Statistics (GRNS 6364)

This is a required course in the Nursing Ph.D. program. The course consists of ten learning modules and and two major projects over a 16 week period. The course presents an overview of common statistical methods and provides a hands-on approach to data analysis. Fundamental statistics concepts will be discussed leading to univariate statistics and then moving on to more advanced statistical methods. Students will learn ways to explore the data using graphs and descriptive statistics. The course will also cover hypothesis testing and model building. This course is conducted fully online. Evaluation and grades will be based on the student's performance on the assignments, data analysis projects and class participation.

Course Instructor: Hoang Nguyen, PhD

Concepts and Theories in Nursing (GNRS 6400)

The course provides an introduction to the nature of scientific inquiry and theoretical conceptualizations within the discipline of nursing. Origins and strategies of theory development and concept analysis are examined with particular emphasis on methods and processes of theory construction, application and evaluation and approaches to concept analysis. Theories and concepts will be evaluated within the context of published research reports. Evaluation of student progress and mastery is determined by class participation, written papers and formal presentations.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: I
Year offered: Annually
Hours per week: Lecture 4
Instructor: Dr. Yolanda Davila

Research Practicum (6039)

As part of the research development of the nursing PhD student, this course is designed to provide the student with opportunities to practice and master a variety of research skills and competencies. Building upon prior didactic learning, students in this experience have the opportunity to select specific areas of research interest and work directly with a faculty researcher in a specific project and role.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor. A course plan must be completed, signed by both the faculty and the student, and submitted to and approved by the Nursing PhD program director.
Terms offered: I, II, III
Year offered: Annually
Hours per week: Variable

Quantitative Research Methods (GNRS 6346)

This course is designed to explore the use of quantitative research approaches in the study of human response, health promotion, and healing processes in nursing. The course focuses on quantitative research methodologies, including designs, sampling, measurement methods, and analysis. Emphasis will be placed on models used in writing quantitative questions and hypotheses, and on the governing principles and decision points of research design. Students will be given the opportunity to develop their ideas about human response, health promotion, and healing processes in nursing in the design of a research project using quantitative approaches. Evaluation of student progress is based on participation, presentation, and paper.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Mary O’Keefe

Qualitative Data Management (GNRS 6351)

This course continues the exploration of qualitative research that began with GNRS 6348: Qualitative Research Methods. The course introduces students to qualitative data management techniques and a variety of analytic strategies used by qualitative researchers to transform and interpret qualitative data. Data analytic strategies are discussed and critiqued from a variety of perspectives, including the impact of the philosophical foundations of selected qualitative approaches on the forms of data collected and how data are managed and analyzed. Practical experiences will assist students to develop the beginning skills required to collect and analyze qualitative data , make informed decisions about analytic strategies, articulate the thinking that supports data analyses, report qualitative findings and interpretations, and engage in detailed discussions of trustworthiness. Ethical and practical issues related to online qualitative research as well as selected computer software programs that support data collection, management and analysis are examined and critiqued. Theoretical and practical issues relevant to the contributions qualitative research can make to nursing's knowledge of human response, health promotion and healing are discussed. Evaluation of student progress is based on class participation, data collection, management and analysis, written papers, class presentations and critiques.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor; GNRS 6400, 6341, 6348
Term offered: I
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Carolyn Phillips

Nursing Science II (GNRS 6358)

This course builds upon Nursing Science I, emphasizing application of theories and research processes related to Health Promotion, Healing and Human Response within the context of Biobehavioral, Vulnerable Populations, and Contemporary Pedagogy research. Students learn principles of human subjects' protection and develop skills in analysis and synthesis of research data, delineation of researchable question(s), and identifying appropriate research methodology. Evaluation is based on completion of online modules, participation, presentations, written papers, and journal assignments.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Mary O’Keefe

Curriculum Design (GNRS 5322)

This course provides a theoretical basis for understanding the principles of curriculum design and evaluation as applied to programs of higher education in nursing. Trends and issues in nursing, health care, and society are explored as they affect the process of curriculum development. Opportunities to practice the elements of curriculum building including the role of philosophy/mission statements, framework development (both conceptual and theoretical), program objectives/outcomes, content mapping, course sequencing, clinical practice, and evaluation will be provided.

Prerequisites: Graduate standing and consent of instructor
Term offered: I, II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Stephens

Health Care Policy (GDNP 6325)

This course examines current issues in health care policy in the U.S. and the role of nurse leaders in affecting policy change. The influence of different political and economic conditions on health policy is analyzed within the context of historical, socioeconomic, ethical, legal and global perspectives. Students will engage in policy analysis and strategic planning of improving health care policy. The overall goal is to stimulate leadership in the policy process in advancing the profession of nursing and the health care of the public, with an emphasis on vulnerable populations.

Prerequisites: Graduate standing and consent of instructor
Term offered: I, II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Linda Rounds

Informatics in Transformation of Healthcare (GDNP 6337)

This course presents the application of informatics and technology to health care. Successes and failures in implementation of information technology are evaluated, with a focus on practice improvement, innovative practice models, and disruptive innovation. Topics will address the collection and use of data for policy and quality within healthcare settings. Information technology as a mode to transform healthcare delivery will be stressed. Upon completion of this course and its related activities, the student will have demonstrated the ability to:
1. Explain traditional use of data in healthcare delivery systems.
2. Examine salient issues related to the use of data in healthcare decision-making.
3. Analyze the impact of informatics and technology on the development of health policies, practice improvement, and disruptive innovations.
4. Analyze the value of informatics and technology for professional nursing and advanced practice nursing.
5. Apply information to address a health disparities issue.

Prerequisites: Graduate standing and consent of instructor
Term offered: I, II
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Linda Rounds

Ethics in Health Care and Research (GNRS 6347)

This course examines substantive moral and ethical issues that emerge in contemporary health care and explores the technological, socio-political, legal, and economic variables that have helped shape these dilemmas. There is an analysis of nurses’ and other health professionals’ historical traditions as moral agents and patient advocates as well as analysis of current ethical-legal obligations and challenges/barriers to those advocacy roles in a rapidly changing health care environment. The course explores comparative ethical theories and models of ethical decision-making that may serve as a framework for guiding both clinical practice and scholarship in health care. There is also an examination of ethical-legal issues that arise in the context of conducting research. Evaluation of student progress is based on seminar participation, oral presentation, and term paper.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: III
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Darlene Martin

Clinical Investigations in Nursing (GNRS 6350)

This course focuses on specific clinical investigations in nursing with emphasis on health promotion, human response to illness, and healing practices. The use of concepts and theories in clinical investigation, methodological issues in data management, and instrumentation and measurement are examined within the context of clinical significance to nursing practice. Evaluation of student progress is based on research analysis, completion of a proposal, and seminar participation.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor; GNRS 6357, 6358
Term offered: III
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Terese Verklan

Quantitative Data Management (GNRS 6361)

This is a course in research data management specifically focused on facilitating the design and implementation of quantitative research projects as well as the preparation of data for statistical analyses. It is intended to address required database structures for existing statistical packages to reinforce basic principles of research design and required statistical level of measurement for proper analytical decisions. Students will be required to design and set up basic database, collect an exemplar sample of data, then test their data structures with basic, widely used statistical computer analyses through a series of computer exercises utilizing SPSS as an exemplar. Weekly homework assignments will address data structure, level of measurement, coding, documentation, selection of variables appropriate to various analyses and exemplar statistical computer analyses. Finally, exercises with translating results into graphic displays will complete the cycle of design, collection, data entry, data verification, data analyses and display.

Prerequisites: Admission to the Nursing PhD Program or permission of instructor
Term offered: III
Year offered: Annually
Hours per week: Lecture 3
Instructor:

Program Evaluation (GNRS 5311)

Program evaluation encompasses curriculum, students, faculty and educational environments. The course will include developing assessment and evaluation methods including student learning outcomes for use in multiple educational environments. Also preparing recommendations from the information and data received from assessments will be included. The course will conclude with the review of the importance of program evaluation for quality improvement and approval from accrediting agencies.

Prerequisites: Graduate standing and consent of instructor
Term offered: I, II, III
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Stephens

Learning Environment (GNRS 5312)

The course will focus on elements of the learning environment including the role of the faculty as the facilitator of learning and considerations of the learner in multiple educational environments. As a facilitator of learning, innovative educational strategies that promote learning and the use of emerging technologies will be explored in multiple educational environments. Appropriate assessment techniques will validate the completion of the learning outcomes.

Prerequisites: Graduate standing and consent of instructor
Term offered: I, II, III
Year offered: Annually
Hours per week: Lecture 3
Instructor: Dr. Stephens

Pharmacology & Toxicology Course Descriptions

Lab Rotation (PHTO 6022)

The objectives of this course are to acquaint students with the research activities of individual faculty members and to assist students in choosing their areas of specialization. The faculty member and student will design a research project and work out a time schedule committing the student to three to 24 hours per week in the laboratory. The student will prepare an abstract describing the objectives and methodology of the study and then conduct the study under the faculty member's supervision. A final report stating the methods, results, interpretation, problems encountered, and suggestions for future research will be required. In addition to carrying out the research proposal the student will be expected to gain a knowledge of the current literature relevant to the project. Grading will be based on the student's laboratory performance, final written report, and an oral presentation of the project. Grading will be A, B, C, F. Normally, a student entering the program without an advanced degree will be required to complete 12 hours of credit with a grade of B or better prior to gaining admission to candidacy. Individual requirements may vary depending on the research experience of the student.

Prerequisites: None
Terms offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 3 24

Capstone (PHTO 6094)

Description: This course is for students pursuing a Master’s degree and who are not doing a thesis or dissertation but instead are carrying out a project or capstone. The project/capstone consists of any of the following activities: i) Writing a review paper on a topic that the student will select together with a mentor and/or a committee; ii) Writing a short research paper on a topic that the student will select together with a mentor and/or a committee; iii) Hands-on activity that would result in generating/optimizing a protocol or establishing an assay; iv) Computational exercise around a well-defined scientific project that includes bioinformatics or data analysis; v) Internship in industry with written report. Grades are based on a satisfactory or unsatisfactory performance.

Prerequisites: None
Terms offered: I,II,III
Year offered: Annually
Hours per week: Laboratory 3-6
Instructor: Laezza

Research (PHTO 6097)

Research on thesis or dissertation project under the direction of supervising professor. The research is graded as satisfactory (S) or unsatisfactory (U).

Prerequisites: None
Term offered: I, II, III
Year offered: Annually
Hours per week: Laboratory 3 27

Thesis (PHTO 6098)

Formal research and writing leading to the preparation and completion of the thesis for the Master of Science degree under the direction of the student's supervisory committee. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as satisfactory or unsatisfactory.
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually

Dissertation (PHTO 6099)

Once admitted to candidacy, it is required for students pursuing the Doctor of Philosophy degree to enroll in this course. This course is for the formal research and writing leading to the preparation and completion of the dissertation for the Doctor of Philosophy degree while under the direction of the student’s supervisory committee. The student will pursue the proposed research and present a progress report and/or agreed upon objectives to the mentor and/or supervisory committee for approval and recommendations. Grading will be based upon the student's level of performance as reported by the chairperson of the student's supervisory committee and will be assigned as Satisfactory (S), Needs Improvement (N), or Unsatisfactory (U).
Prerequisites: Admission to candidacy
Terms offered: I, II, III
Year Offered: Annually
Hours per week: Variable 3-9

Addiction Sciences and Neurotherapeutics (PHTO 6120)

This course will provide an interactive work-group for trainees to discuss their research in addiction science with graduate students, postdoctoral fellows, and faculty. Emphasis will be placed on therapeutic development and trainees will learn how to approach existing projects with a therapeutic development prospective. Presentation formats will vary in scope and level of analysis, depending on the needs of the trainee. Examples of trainee presentation formats include: expansion of an existing project for grant proposal development, and detailed discussion of data analysis and interpretation. Intermittently, faculty will present information on their research program to provide students with an overview of cutting-edge neuroscience and drug discovery/development topics. Grades will be satisfactory/unsatisfactory based on in-class participation and presentations quality.

Prerequisites: None
Term offered: I, II
Year offered: Annually
Hours per week: 1
Instructor: Dr. Jonathan Hommel

Neuroaddicts Journal Club (PHTO 6121)

The Neuroaddicts Journal Club provides a more cohesive venue for trainees and exposes mentees to a wider range of neuroscience and addictions topics. The goals are for mentees to learn critical thinking of the published literature, the requirements and construction of high quality manuscripts, and presentation skills. Within this environment, mentees have a prime opportunity to refine the ability to converse in both scientific and collegial domains, and become comfortable with asking questions and thinking critical/constructively.

Prerequisites: None
Term offered: I, II
Year offered: Annually
Hours per week: 1
Instructor: Dr. Noelle Anastasio

Advances in Mental Health Research (PHTO 6123)

This course will provide a solid understanding of current mental health research and promote understanding of factors advancing future groundbreaking mental health research. The course will have flexible format, including sessions where students discuss relevant papers, present their own data, discuss a wide range of career-development issues, learn about pharmacotherapeutic development, learn advanced grant-writing principles, discuss relevant ethical issues, and learn advanced research techniques. Attendance 50%, participation in classroom discussion 50%. A satisfactory grade requires a score of 80%.

Prerequisites: None
Term Offered: I, II, III
Year Offered: Annually
Hours Per Week: 2
Instructor: Dr. Thomas Green and Dr. Fernanda Laezza

Bioinformatics Tools and Applications (PHTO 6125)

The goal of the class is to introduce the students to the various bioinformatics tools available for the analysis DNA and RNA sequencing data. Students will be provided with an overview of the most common bioinformatics tasks they will face in the research. During the class, students will have hands on experience performing analysis of the data generated by the variety of scientific instruments and bioinformatics tools addressing real-life clinical and scientific applications. The class will be divided into three sections: pathogen detection, gene expression, and microbiome analysis. Students will be taught how to use public bioinformatics resources such as GeneBank, SRA, PATRIC, SILVa, and I2B2.

Prerequisites: None
Terms offered: III
Year offered: Annually
Hours Per Week: 1
Instructor: Dr. George Golovko

Environmental Toxicology Research Review (PHTO 6126)

This course begins in the Fall term and extends to the Spring term. It is an open discussion and presentation course, and will include monthly presentation of current literature papers, selected by the students, in consultation and development with the Course Director, prior to each presentation. This will include: 1) the process of paper selection, 2) the review of potential auxiliary papers, and 3) distribution of the papers to the class participants. Using guidelines developed by the Course Director, students will each present 1-2 papers from the current toxicology-relevant literature, in a semi-formal presentation venue, with an open discussion format. In this discussion time, presenting students will be responsible for the development and delivery of presentation on their selected research paper(s). Areas required to be covered within the presentation are: 1) hypothesis, 2) methods and approach, 3) statistical analyses, 4) main finding(s), 5) appropriateness of overall conclusions, 6) strengths and weaknesses of study, and 6) whether they would accept the paper for publication as is, or with modification(s), and what those modifications, if necessary, would be. Open discussion will include questioning the presenter about various important aspects of the study being presented, including the hypothesis, experimental design, statistics, and results. Students register for the course in both terms. A grade of “G” (longitudinal) will be assigned at the end of the Fall term and a single, 1-hour course grade will be assigned at the end of the Spring term. Grading will be based on paper presentation, participation in classroom discussion, and attendance.

Prerequisites: Permission of course director
Terms offered: I, II Longitudinal
Year offered: Annually
Hours per week: Lecture 2
Instructor: Ameredes

Physiology and Pharmacology of ion channel and receptor signaling (PHTO 6127)

This course provides a general background in cellular neuroscience with an emphasis on neuronal synaptic transmission. The first part of the course covers structure and molecular composition of excitatory and inhibitory synapses. Topics covered include: synaptic structure and dynamics, molecular composition of post-synaptic ligand-gated ion channels, metabotropic receptors, signal transduction pathways, functional analysis of postsynaptic currents, synaptic plasticity and neuronal homeostasis. The second part of the course includes an in-depth reading and discussion of topics related to synaptic receptors mediating neuronal transmission in the central nervous system. This course will prepare students for upper level Neuroscience and Neuropharmacology courses and is also suitable for students interested in basic cellular mechanisms underlying brain function. Grading is based on written midterm and final examinations. Grading will be on a Standard A-F basis.

Prerequisites: BBSC 6303 Biochemistry, BBSC 6302 Cell Biology, or consent of the instructor
Term offered: II
Year offered: Annually
Hours per week: 1
Credit: 1
Instructor: Dr. Fernanda Laezza

Pharmacology & Toxicology Student Journal Club (PHTO 6190)

This course is designed to provide an opportunity for students to practice formal presentation skills and discuss science. Students will select research articles from pharmacological journals for presentation to students and student groups. Each student will present and discuss at least one paper per semester depending on the number of students enrolled in the course. Grades will be based on attendance and quality of presentation. Pharmacology students are required to be enrolled in this course every term offered, except for the last term.

Prerequisites: None
Term Offered: I, II
Year Offered: Annually
Hours Per Week: Conference or Discussion 1
Instructor: Dr. Miriam Falzon

Seminar in Pharmacology & Toxicology (PHTO 6195)

Presentations by guest lecturers, staff, and students on the progress of their own research, as well as review of recent advances in pharmacology and toxicology. The course begins in the Fall term and extends over all 3 terms of the academic year. Students must register for it each term. A grade of “G” (in progress) will be assigned at the end of the Fall and Spring terms, and a single, 1-hour course grade will be assigned at the end of the Summer term. Students are to attend 15 PHTO seminars total, the Summer PHTO Graduate Symposium, and PHTO PhD preliminary exam presentations. Enrollment in this course is required every term except graduating term. Grading is Satisfactory (S) or Unsatisfactory (U).

Prerequisites: None
Term offered: I, II, III Longitudinal
Year offered: Annually
Hours per week: Seminar 1
Instructor: Dr. Kangling Zhang

Principles of Drug Action, Pharmacokinetics and Biotransformation (PHTO 6208)

This eight-week course will cover the principles underlying drug and toxin mechanisms of action, as well as their metabolism and clearance. In particular, we will focus on mechanisms underlying the interaction between hormone and neurotransmitter receptors and full, partial, and inverse agonists, as well as analysis of the mechanisms underlying the actions of competitive, partially competitive and non-competitive inhibitors. Additionally, the mechanisms underlying allosteric modulation by drugs and endogenous ligands will be discussed along with how receptor activation engages underlying effector mechanisms. The latter portion of the course will focus on the mechanisms underlying absorption, distribution, elimination and metabolism of both toxins and therapeutic drugs. This will include metabolism by phase I and phase II enzymes, glutathione reductase, as well as drug elimination, duration of action, plateau principle, and continuous and intermittent dosing paradigms. The course will be taught primarily in lecture format with discussion of primary research articles. Grading will be based on class participation, homework problems, two written exams and a 15-minute oral presentation covering the similarities and differences between a pair of drugs that have similar therapeutic goals. Grading will be on a Standard A-F basis.

Prerequisites: PHTO 6302, Cell Biology and PHTO 6401 Biochemistry or consent of instructor
Terms offered: II,
Year offered: Annually
Hours per week: 6

Synthetic Methods to Biomolecules (PHTO 6211)

Modern methods for the synthesis of biomolecules will be covered. Biomolecules include various natural products, unnatural amino acids, peptides, nucleotides, carbohydrates, bioactive small molecular chemical probes and drug candidates. The lecture topics will include modern synthetic methods that are useful to access various biomolecules. These synthetic methods include but not limit to solid phase synthesis, combinatorial synthesis, and fundamental organic synthetic approaches such as reductions, oxidations, functional group protections, carbon-carbon bond formation, asymmetric alkylation, asymmetric allylation, metal-halogen exchange, organolithium reagents, directed ortho metalation, Stille reaction, Suzuki reaction, Heck reaction, stereoselective aldol reaction, olefination, asymmetric epoxidation and catalytic epoxide-opening reactions, asymmetric Diels-Alder reaction, olefin metathesis, synthetic methods for heterocyclic compounds, etc.

Prerequisites: Undergraduate Organic Chemistry
Term offered: II
Year offered: Annually
Hours per week: Lecture 2
Instructor: Dr. Jia Zhou

Endocrine, Chemotherapy, and Toxicology Pharmacolog (PHTO 6213)

Survey of Pharmacology course covering drugs that affect the endocrine system, drugs used in cancer chemotherapy, anti-parasitic drugs, drugs to treat gastrointestinal (GI) system, anti-dhistomines, anti-inflammatory drugs and an introduction to toxicology and specific toxic agents.

Prerequisites: None
Terms offered: II
Year offered: Annually
Hours per week: Lecture 4
Instructor: Dr. Miriam Falzon

New Drug Development (PHTO 6219)

This course will provide a comprehensive overview of the drug discovery and development process, focusing on drug development science, regulation, and industry. Students will learn how promising new drugs are discovered, screened, and evaluated from the standpoint of their safety and efficacy.

How drug commercialization decisions are made at each major phase in the drug development process. How information technology is used to increase drug development productivity as well as enhance the commercial potential of drug candidates. Topics include: Molecules to medicines; Drug discovery, design, and screening; Early testing and Safety; Clinical research; Global drug review and approval, Trends and issues in pharmaceutical drug development; Case history, etc. The course grade will be based on class participation (50%) and class project and presentation (50%).

Term offered: Summer
Year offered: Annually
Hours per week: Lecture, conference and discussion 4
Faculty: Zhou, Staff

Neuropharmacology (PHTO 6223)

An eight week course meeting three times per week to present the principles of the study of drugs that influence neural systems. The format of the course will be a combination of faculty and student presentations and discussion. Grades will be based upon two exams, a research paper, and a student presentation.

Prerequisites: Permission of instructor or BBSC Core Curriculum
Term offered: I
Year offered: Annually
Hours per week: Lecture 4; Conference or Discussion 1; Laboratory 6

Intro Tox Risk Assessment (PHTO 6224)

The objective of this course is to provide a basic foundation on the toxicological risk assessment process. The course format is lecture-based with supplement from online materials and experiences, as well as practical application aligned with book chapter commentary, and case studies. Students will be provided a risk assessment simulation exercise to experience and understand the risk assessment process. Within this course, students learn about: 1) the building blocks of risk assessment, 2) the risk assessment process, 3) how risk assessment is applied and used in decision making scenarios, 4) current and emerging issues in risk assessment, and 5) the skills and professional resources available to those interested in risk assessment. After completing the course, the student will be able to: 1) define and explain toxicological risk assessment, 2) comprehend the application of risk assessment, 3) demonstrate effective use of risk assessment technique, 4) demonstrate competent science and math skills associated with risk assessment, 5) employ ethical principles in the application of risk assessment, 6) demonstrate the ability to work effectively in teams and in discussion-based format. Course performance grading will be standard letter grades, based on exams, individual projects, class participation/discussion, and attendance.

Prerequisites: None
Term offered: I
Year offered: Even Years
Hours per week: 2
Instructor: Dr. Sol Bobst

Introduction of Regulation Toxicology (PHTO 6226)

The objective of this course is to provide a basic foundation in regulatory toxicology methods, requirements, and practical skills. The course format is a hybrid of online lectures and webinars supplemented with online materials as well as practical application aligned with project examples. Students will be provided an opportunity to 1) learn the requirements for toxicology testing for pharmaceutical products and medical devices 2) learn the requirements for toxicology testing for food, cosmetics, industrial chemicals, and consumer products 3) learn the background and application of publicly available toxicology databases, and how the data can be used for experimental and regulatory purposes, as well as a practical exercise using a database for a project and focused outcome. Grading of course performance will be standard letter grades, based on exams, individual projects, class participation/discussion, and attendance.

Online discussions will be asynchronous with clear start times and deadlines for students to post to the discussion forum. Students are expected, at the minimum, to provide at least one initial post and one reply post for each weekly topic. Depending on the course size, students may be asked to lead discussions for the week. The course instructor will set the course discussion question for the week and provide the journal club citation and pdf if necessary, though students will be encouraged to use their library research skills when papers are available that way. At the end of the discussion week, students will be graded on their level of participation. The expectations for online discussions will be explained, along with a grading rubric for the assignment of grades that is based on the quality and content of the online discussion postings. Lecture notes will also be available within Blackboard on a weekly basis, so that students have the course material available to them during the week, and if they bring laptops to the course, they can use interactive tools on risk assessment during lectures or discussions to meet the applied learning objectives.

Prerequisites: Instructor or Director Approval
Term offered: II
Year offered: Annually
Hours per week: Lecture 2 Discussion
Instructor: Dr. Sol Bobst

ACC Pharmacology (PHTO 6312)

This fifteen-week course serves as an introduction to the cellular, biochemical, and molecular effects of pharmacological agents acting on the autonomic and central nervous systems as well as the cardiovascular and renal systems. Prior to detailed presentations of the various classes of agents used to treat disorders of the aforementioned systems, the pertinent physiology of each system will be reviewed. The therapeutic use, mechanism of action, adverse effects, and absorption, distribution, and metabolism will be emphasized for each pharmacological agent presented in class. This course will be graded on the basis of four in-class examinations.

Prerequisites: None
Term offered: I
Year offered: Annually
Hours per week: 4.5
Instructor: Dr. Kenneth Johnson

Genome-Wide Analytical Technologies for Biomedical Research (PHTO 6318)

New developments in technologies such as proteomics, metabolomics, epigenetics, and molecular imaging are expanding our knowledge of the biological world at a rapid pace. These analytical approaches and expertise are accessible at UTMB. The student is offered education in cutting-edge technologies for application in biomedicine. The course is a blend of lectures, literature seminars, and practical demonstrations of data acquisition and data analysis. At the end of the course, the student will be able to identify and apply experimental strategies that best fit their biomedical experimental hypothesis. Grading: The examination will consist of a 5 page research proposal that describes the application of genome-wide technologies to a biomedical hypothesis. The exam will effectively integrate the student's working knowledge of materials discussed in seminars, lectures and practical demonstrations.

Principles of Environmental Toxicology (PHTO 6319)

This course will be a graduate-level presentation of fundamental principles of environmental toxicology, including basic concepts like ADME (absorption, distribution, metabolism, and excretion), mechanisms of toxicity and injury, inflammation and ROS, overviews of discipline-specific toxicology (e.g., genetic toxicology, immunotoxicology, and toxicant-associated carcinogenesis), as well as organ-system-based toxicology covering major organ systems of the body (e.g., neurotoxicology, hepatotoxicology, renal toxicology, cardiovascular toxicology, and respiratory toxicology), and including developmental toxicology. Grades will be calculated based on upon 2 mid-term and final in-class exams, and class attendance.

Prerequisites: None
Term offered: I
Year offered: Odd Years
Hours per week: 3
Instructor: Dr. Bill Ameredes