Publications

Below are selected publications of note from work produced from the Mass Spectrometry Facility:

  • 2025

    • Fulp K, Obaleye O, Wang S, Liu X, Yu J, Kurie JM, Xu J, Russell WK, Tan X, Xiao GY. “EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression.” [Preprint]. 2025 Dec 22:2025.11.12.688098. doi: 10.1101/2025.11.12.688098. PMID: 41292834.
    • Ghosh M, Wu C, Kumar A, Nilsson MB, Heymach JV, Zhao W, Yu J, Liu X, Ding N, Wang S, Xiao GY, Chen A, Grimley KV, Russell WK, Creighton CJ, Tan X, Kurie JM. “Osimertinib activates a TGFβ2-dependent secretory program that drives lung adenocarcinoma progression.” J Clin Invest. 2025 Dec 9:e198418. doi: 10.1172/JCI198418. Online ahead of print. PMID: 41364502.
    • O'Leary S, Prasai A, Robledo A, Thang C, Wang Y, Deshpande RR, Russell WK, Murton AJ, Wolf SE, El Ayadi A. “Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury.” Front Immunol. 2025 Dec 1;16:1709256. doi: 10.3389/fimmu.2025.1709256. eCollection 2025. PMID: 41403939.
    • Badten AJ, Oaxaca-Torres S, Basu RS, Gagnon MG, Torres AG. Evaluation of Highly Conserved Burkholderia pseudomallei Outer Membrane Proteins as Protective Antigens Against Respiratory Melioidosis. Res Sq [Preprint]. 2025 May 13:rs.3.rs-6549424. doi: 10.21203/rs.3.rs-6549424/v1. Update in: NPJ Vaccines. 2025 Aug 6;10(1):186. doi: 10.1038/s41541-025-01246-2. PMID: 40470231; PMCID: PMC12136189.
    • Badten AJ, Oaxaca-Torres S, Basu RS, Gagnon MG, Torres AG. Evaluation of highly conserved Burkholderia pseudomallei outer membrane proteins as protective antigens against respiratory melioidosis. NPJ Vaccines. 2025 Aug 6;10(1):186. doi: 10.1038/s41541-025-01246-2. PMID: 40770240; PMCID: PMC12328632.
    • Tan X, Wu C, Banerjee P, Wang S, Cardin DL, Xu Y, Creighton CJ, Russell WK. “Dichotomous roles of ACBD3 in NSCLC growth and metastasis.” Oncogene. 2025 Jul;44(25):2078-2090. doi: 10.1038/s41388-025-03360-w. Epub 2025 Apr 6. PMID: 40189704.
    • Tan X, Cardin DL, Wang S, Xu Y, Russell WK. “Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4.” Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2501347122. doi: 10.1073/pnas.2501347122. Epub 2025 Jul 9. PMID: 40632561.
    • Cabello AL, Wells K, Peng W, Feng HQ, Wang J, Meyer DF, Noroy C, Zhao ES, Zhang H, Li X, Chang H, Gomez G, Wan M, Mao Y, Patrick KL, Watson RO, Russell WK, Yu A, Zhong J, Guo F, Li M, Zhou M, Qian X, Kobayashi KS, Song J, Panthee S, Mechref Y, Ficht TA, Qin QM, de Figueiredo P. “Brucella-driven host N-glycome remodeling controls infection.” Cell Host Microbe. 2025 Jul 9;33(7):1208. doi: 10.1016/j.chom.2025.05.023. Epub 2025 Jun 17. PMID: 40532706.
    • Bowen CM, Ditmars F, Liu N, Abril JM, Ajasin D, Russell WK, Stevenson HL, Eugenin EA, Fair JH, Fagg WS. “Amniotic fluid reduces liver fibrosis by attenuating hepatic stellate cell activation.” Stem Cells Transl Med. 2025 Jun 25;14(7):szaf026. doi: 10.1093/stcltm/szaf026. PMID: 40622454.
    • Kilroe SP, Von Ruff ZD, Arentson-Lantz EJ, Romsdahl TB, Linares JJ, Kalenta H, Marchant ED, Volpi E, Paddon-Jones D, Russell WK, Rasmussen BB. “Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome.” Am J Physiol Endocrinol Metab. 2025 Jun 1;328(6):E962-E978. doi: 10.1152/ajpendo.00012.2025. Epub 2025 Apr 29. PMID: 40298387.
    • Wang Y, Sun L, Fernandes L, Wang YH, Zou J, Franklin SJ, Hu Y, Palmer LK, Yeung J, Barriga D, Russell WK, Moquin SA, Shi PY, Skepper C, Xie X. “Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688.” Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2426922122. doi: 10.1073/pnas.2426922122. Epub 2025 Mar 28. PMID: 40153462.
    • Wang S, Guo H, Fukushima R, Terajima M, Liu M, Xiao GY, Koudelková L, Wu C, Liu X, Yu J, Burris E, Xu J, Schiavinato A, Russell WK, Yamauchi M, Tan X, Kurie JM. “Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression.” J Clin Invest. 2025 Apr 1;135(7):e189197. doi: 10.1172/JCI189197. PMID: 40166934.
    • Johnson OD, Paul S, Gutiérrez JA, Russell WK, Ward MC. “DNA-damage-associated protein co-expression network in cardiomyocytes informs on tolerance to genetic variation and disease.” iScience. 2025 Apr 18;28(5):112474. doi: 10.1016/j.isci.2025.112474. eCollection 2025 May 16. PMID: 40469117.

  • 2024

    • Versteeg L, Adhikari R, Robinson G, Lee J, Wei J, Islam N, Keegan B, Russell WK, Poveda C, Villar MJ, Jones K, Bottazzi ME, Hotez P, Tijhaar E, Pollet J. Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate. PLoS Pathog. 2024 Dec 18;20(12):e1012764. doi: 10.1371/journal.ppat.1012764. PMID: 39693359; PMCID: PMC11654963.
    • Molecular mechanism of contactin 2 homophilic interaction. Fan S, Liu J, Chofflet N, Bailey AO, Russell WK, Zhang Z, Takahashi H, Ren G, Rudenko G. Structure. 2024 Oct 3;32(10):1652-1666.e8. doi: 10.1016/j.str.2024.06.004. Epub 2024 Jul 4. PMID: 38968938.
    • Lin MH, Jensen MK, Elrod ND, Chu HF, Haseley M, Beam AC, Huang KL, Chiang W, Russell WK, Williams K, Pröschel C, Wagner EJ, Tong L. Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function. Mol Cell. 2024 Aug 8;84(15):2900-2917.e10. doi: 10.1016/j.molcel.2024.06.017. Epub 2024 Jul 19. PMID: 39032490; PMCID: PCD11316654.
    • Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function. Lin MH, Jensen MK, Elrod ND, Chu HF, Haseley M, Beam AC, Huang KL, Chiang W, Russell WK, Williams K, Pröschel C, Wagner EJ, Tong L. Mol Cell. 2024 Aug 8;84(15):2900-2917.e10. doi: 10.1016/j.molcel.2024.06.017. Epub 2024 Jul 19. PMID: 39032490.
    • Filling the gaps in peptide maps with a platform assay for top-down characterization of purified protein samples. Bailey AO, Durbin KR, Robey MT, Palmer LK, Russell WK. Proteomics. 2024 Jul 14:e2400036. doi: 10.1002/pmic.202400036. PMID: 39004851.
    • Microneedle-based sampling of dermal interstitial fluid using a vacuum-assisted skin patch. Jiang X, Wilkirson EC, Bailey AO, Russell WK, Lillehoj PB. Cell Rep Phys Sci. 2024 Jun 19;5(6):101975. doi: 10.1016/j.xcrp.2024.101975. PMID: 38947182.
    • Matheny CJ, Qadota H, Bailey AO, Valdebenito-Silva S, Oberhauser AF, Benian GM. The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging. Mol Biol Cell. 2024 Jul 1;35(7):ar98. doi: 10.1091/mbc.E23-12-0488. Epub 2024 May 29. PMID: 38809582.
    • Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. Tan X, Wang S, Xiao GY, Wu C, Liu X, Zhou B, Yu J, Duose DY, Xi Y, Wang J, Gupta K, Pataer A, Roth JA, Kim MP, Chen F, Creighton CJ, Russell WK, Kurie JM. J Clin Invest. 2024 Apr 25:e176355. doi: 10.1172/JCI176355. Online ahead of print. PMID: 38662435.
    • Cabello AL, Wells K, Peng W, Feng HQ, Wang J, Meyer DF, Noroy C, Zhao ES, Zhang H, Li X, Chang H, Gomez G, Mao Y, Patrick KL, Watson RO, Russell WK, Yu A, Zhong J, Guo F, Li M, Zhou M, Qian X, Kobayashi KS, Song J, Panthee S, Mechref Y, Ficht TA, Qin QM, de Figueiredo P. Brucella-driven host N-glycome remodeling controls infection. Cell Host Microbe. 2024 Apr 10;32(4):588-605.e9. doi: 10.1016/j.chom.2024.03.003. Epub 2024 Mar 25. PMID: 38531364.
    • Woodward A, Southard B, Chakraborty S, Bailey AO, Faria GNF, McKernan P, Razaq W, Harrison RG. Mol Biomed. Annexin A5-DM1 protein-drug conjugate for the treatment of triple-negative breast cancer. 2024 Feb 19;5(1):7. doi: 10.1186/s43556-023-00167-7. PMID: 38369647.
    • Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH. An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. Nat Commun. 2024 Jan 26;15(1):756. doi: 10.1038/s41467-024-44959-z. PMID: 38272938.

  • 2023

    • Banerjee P, Tan X, Russell WK, Kurie JM. Analysis of Golgi Secretory Functions in Cancer. Methods Mol Biol. 2023; 2557:785-810. doi: 10.1007/978-1-0716-2639-9_47. PMID: 36512251.
    • Maroto R, Graber TG, Romsdahl TB, Kudlicki A, Russell WK, Rasmussen BB. Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1. J Nutr. 2023 Dec;153(12):3397-3405. doi: 10.1016/j.tjnut.2023.10.016. Epub 2023 Oct 28. PMID: 37898335.
    • Deberneh HM, Abdelrahman DR, Verma SK, Linares JJ, Murton AJ, Russell WK, Kuyumcu-Martinez MN, Miller BF, Sadygov RG. A large-scale LC-MS dataset of murine liver proteome from time course of heavy water metabolic labeling. Sci Data. 2023 Sep 19;10(1):635. doi: 10.1038/s41597-023-02537-w. PMID: 37726365.
    • Xiao GY, Tan X, Rodriguez BL, Gibbons DL, Wang S, Wu C, Liu X, Yu J, Vasquez ME, Tran HT, Xu J, Russell WK, Haymaker C, Lee Y, Zhang J, Solis L, Wistuba II, Kurie JM., EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2220276120. doi: 10.1073/pnas.2220276120. PMID: 37406091.
    • Deberneh HM, Abdelrahman DR, Verma SK, Linares JJ, Murton AJ, Russell WK, Kuyumcu-Martinez MN, Miller BF, Sadygov RG. Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling. Commun Chem. 2023 Apr 17;6(1):72. doi: 10.1038/s42004-023-00873-x. PMID: 37069333.
    • Tan X, Xiao GY, Wang S, Shi L, Zhao Y, Liu X, Yu J, Russell WK, Creighton CJ, Kurie JM. EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer. J Clin Invest. 2023 Apr 3;133(7):e165863. doi: 10.1172/JCI165863. PMID: 36757799; PMCID: PMC10065074.
    • Scaduto P, Lauterborn JC, Cox CD, Fracassi A, Zeppillo T, Gutierrez BA, Keene CD, Crane PK, Mukherjee S, Russell WK, Taglialatela G, Limon A. Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change. Acta Neuropathol. 2023 Mar;145(3):303-324. doi: 10.1007/s00401-022-02526-0. Epub 2022 Dec 20. PMID: 36538112; PMCID: PMC9925531.
    • Lee H, Chofflet N, Liu J, Fan S, Lu Z, Resua Rojas M, Penndorf P, Bailey AO, Russell WK, Machius M, Ren G, Takahashi H, Rudenko G. Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function. J Biol Chem. 2023 Mar 7;299(4):104586. doi: 10.1016/j.jbc.2023.104586. Epub ahead of print. PMID: 36889589.
    • Acuña ML, García-Morin A, Orozco-Sepúlveda R, Ontiveros C, Flores A, Diaz AV, Gutiérrez-Zubiate I, Patil AR, Alvarado LA, Roy S, Russell WK, Rosas-Acosta G. Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms. Sci Rep. 2023 Feb 9;13(1):2309. doi: 10.1038/s41598-023-29357-7. PMID: 36759644; PMCID: PMC9911741.

  • 2022

    • Catherine H. Schein, Grace Rafael, Wendy S. Baker, Elizabeth S. Anaya, Jurgen G. Schmidt, Scott C. Weaver, Surendra Negi, Werner Braun, PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies, Peptides, Volume 157, 2022, Nov. 1.
    • Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang KL, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy S, Russell WK, Amiel J, Reversade B, Wagner EJ. INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex. Nat Commun. 2022 Oct 13;13(1):6054. doi: 10.1038/s41467-022-33547-8. PMID: 36229431; PMCID: PMC9559116.
    • Wang X, Mayorga-Flores M, Bien KG, Bailey AO, Iwahara J. J Biol Chem. DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein. 2022 Nov;298(11):102577. doi: 10.1016/j.jbc.2022.102577. Epub 2022 Oct 8. PMID: 36220391.
    • Wu W, Kim JS, Bailey AO, Russell WK, Richards SJ, Chen T, Chen T, Chen Z, Liang B, Yamauchi M, Guo H. Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus. Sci Rep. 2022 Oct 7;12(1):16806. doi: 10.1038/s41598-022-21197-1. PMID: 36207453; PMCID: PMC9546862.
    • Bajaj R, Rodriguez BL, Russell WK, Warner AN, Diao L, Wang J, Raso MG, Lu W, Khan K, Solis LS, Batra H, Tang X, Fradette JF, Kundu ST, Gibbons DL. Impad1 and Syt11 work in an epistatic pathway that regulates EMT-mediated vesicular trafficking to drive lung cancer invasion and metastasis. Cell Rep. 2022 Sep 27;40(13):111429. doi: 10.1016/j.celrep.2022.111429. PMID: 36170810; PMCID: PMC9665355.
    • Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G. Chemically targeting the redox switch in AP1 transcription factor ΔFOSB. Nucleic Acids Res. 2022 Sep 9;50(16):9548-9567. doi: 10.1093/nar/gkac710. PMID: 36039764; PMCID: PMC9458432.
    • Liu N, Bowen CM, Shoja MM, Castro de Pereira KL, Dongur LP, Saad A, Russell WK, Broderick TC, Fair JH, Fagg WS. Comparative Analysis of Co-Cultured Amniotic Cell-Conditioned Media with Cell-Free Amniotic Fluid Reveals Differential Effects on Epithelial-Mesenchymal Transition and Myofibroblast Activation. Biomedicines. 2022 Sep 5;10(9):2189. doi: 10.3390/biomedicines10092189. PMID: 36140291; PMCID: PMC9495976.
    • Laiakis EC, Pinheiro M, Nguyen T, Nguyen H, Beheshti A, Dutta SM, Russell WK, Emmett MR, Britten RA. Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation. Front Physiol. 2022 Aug 26;13:971282. doi: 10.3389/fphys.2022.971282. PMID: 36091373; PMCID: PMC9459391.
    • Vu MN, Lokugamage KG, Plante JA, Scharton D, Bailey AO, Sotcheff S, Swetnam DM, Johnson BA, Schindewolf C, Alvarado RE, Crocquet-Valdes PA, Debbink K, Weaver SC, Walker DH, Russell WK, Routh AL, Plante KS, Menachery VD. QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2205690119. doi: 10.1073/pnas.2205690119. Epub 2022 Jul 26. PMID: 35881779; PMCID: PMC9371735.
    • Smith CA, Ebrahimpour A, Novikova L, Farina D, Bailey AO, Russell WK, Jain A, Saltzman AB, Malovannaya A, Prasad BVV, Hu L, Ghebre YT. Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors. Biochim Biophys Acta Gen Subj. 2022 Aug;1866(8):130149. doi:10.1016/j.bbagen.2022.130149. Epub 2022 Apr 25. PMID: 35472493.
    • Fagg WS, Liu Liu N, Braunschweig U, Pereira de Castro KL, Chen X, Ditmars FS, Widen SG, Donohue JP, Modis K, Russell WK, Fair JH, Weirauch MT, Blencowe BJ, Garcia-Blanco MA. Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate. Nucleic Acids Res. 2022 May 20;50(9):5313-5334. doi: 10.1093/nar/gkac327. PMID: 35544276; PMCID: PMC9122611.
    • Bailey AO, Huguet R, Mullen C, Syka JEP, Russell WK. Ion-Ion Charge Reduction Addresses Multiple Challenges Common to Denaturing Intact Mass Analysis. Anal Chem. 2022 Mar 8;94(9):3930-3938. doi:10.1021/acs.analchem.1c04973. Epub 2022 Feb 21. PMID: 35189062.
    • Fokina V, Patrikeeva S, Wang X, Shah M, Shah P, Russell WK, Ahmed MS, Rytting E, Nanovskaya T. Physicochemical and Biological Properties of Membrane Vesicles Derived from Human Term Placentas. J Biomed Nanotechnol. 2022 Feb 1;18(2):589-599. doi: 10.1166/jbn.2022.3255. PMID: 35484740.