Dr. Toh leads a Clinical Research Center (CRC) at Sibu Hospital in Sarawak. Since its inception in 2017, the CRC has been dedicated to studying respiratory viruses causing pneumonia. The CRC is now at the forefront of groundbreaking research regarding CCoV-HuPn-2018, addressing critical health issues that span human, animal, and environmental health. In this study of CCoV-HuPn-2018 they are collaborating with not only UTMB, but also with researchers from Ohio State University, the US Food and Drug Administration, and SEGi University in Malaysia. This collaboration enhances research capacity at Sibu Hospital which had had a very positive impact upon patient care in Sarawak. In fact, during the recent COVID-19 pandemic, because the CRC had advance laboratory capabilities through its research collaborations, the Malaysia national public health agency relied upon the CRC Laboratory for regional testing for SARS-CoV-2 virus.
Ms. Nur Alfreena Binti Alfie performing lab procedures at the Sibu Hospital CRC Research Lab. (Photo credit: Amrita Chandradas, Singapore)
Dr. Teck-Hock Toh, a Pediatrician and Head of the Clinical Research Centre, Sibu Hospital, Ministry of Health Malaysia, recently discussed the significant CRC's research work with this author. He highlighted the need for integrated surveillance for novel viruses in both humans and animals in a One Health way. His CRC Laboratory serves as the central hub multiple research collaborative efforts and is improving regional public health. The CRC’s research findings could help pave the way for the development of new or improved diagnostic tests and potential vaccines, thereby enhancing public health policies and clinical practices to mitigate the risk of zoonotic outbreaks. The CRC actively engages with the local community through awareness programs and by involving local health practitioners in the studies, thereby strengthening the healthcare infrastructure and fostering a well-informed community.
Dr. Toh seeing research subjects at the Sibu Hospital CRC Clinic. (Photo credit: Amrita Chandradas, Singapore)
One of the main challenges faced by the CRC is the logistical difficulty of coordinating studies across different regions and ensuring the availability of adequate resources. In Sarawak, there is a pressing need for more laboratory experts and facilities for molecular testing. Through partnerships with institutions like UTMB, where expertise and equipment are shared, and skill transfers are facilitated to overcome these challenges. The CRC has continuously strengthened its network of collaborators to address these issues effectively.
Looking ahead, the CRC plans to expand its research to explore the epidemiology of CCoV-HuPn-2018 in patients with pneumonia as well as among healthy subjects. Future research directions will include a broader epidemiological study of canine coronavirus, investigating potential wildlife reservoirs, and assessing the virus's impact on animal and human populations. These efforts aim to provide a comprehensive understanding of the virus and enhance preparedness for future zoonotic threats.
In conclusion, the pioneering research conducted by the CRC at Sibu Hospital exemplifies the One Health approach, addressing the interconnected health challenges faced by humans, animals, and the environment. Through collaboration, innovation, and community engagement, the CRC is making significant strides in understanding and combating zoonotic diseases, ultimately contributing to global health security.
References:
- Vlasova AN, Diaz A, Damtie D, et al. Novel Canine Coronavirus Isolated from a Hospitalized Patient With Pneumonia in East Malaysia. Clin Infect Dis 2022;74(3):446-454. DOI: 10.1093/cid/ciab456.
- Lednicky JA, Tagliamonte MS, White SK, et al. Isolation of a Novel Recombinant Canine Coronavirus From a Visitor to Haiti: Further Evidence of Transmission of Coronaviruses of Zoonotic Origin to Humans. Clin Infect Dis 2022;75(1):e1184-e1187. DOI: 10.1093/cid/ciab924.