Bill T. Ameredes
Bill T. Ameredes, M.S., Ph.D. Professor, Department of Internal Medicine
Director, NIH/NCATS KL2 Scholars Program
Director, NIEHS Environmental Toxicology Training Program
William C. Levin Chair, Environmental Toxicology

Contact Information:
Phone: (409) 772-8104
Fax: (409) 774-5841
Email: btamered@utmb.edu 

Education:
B.S.-Biology, 1981, University of Akron, Akron, OH
M.S.-Biology, 1984, University of Akron, Akron, OH
Ph.D.-Physiology, 1989, Ohio State University, Columbus, OH
Post-Doctoral Associate, 1990, University of Florida, Gainesville, FL
AHA Post-Doctoral Fellow, 1992, University of Florida, Gainesville, FL

Research Interests:

  • Airway remodeling in asthma and COPD 
  • Inhalation toxicology of small molecule and particulate toxicants
  • Upper and lower airway anti-inflammatory effects of novel drug compounds 
  • Airway smooth muscle biology
  • Immune/inflammatory cytokine responses of the airway

Selected Publications:

  1. Ameredes BT, Hellmich MR, Cestone CM, Wooten KC, Ottenbacher KJ, Chonmaitree T, Anderson KE, Brasier AR. The multi-disciplinary translational team (MTT) model for training and development of translational research investigators. Clin Translational Science. 8(5):533-41. Epub 2015 May 23doi: 10.1111/cts.12281. PMID: 26010046 PMCID- PMC4626313, 2015.
  2. Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK. Part 3. Assessment of genotoxicity and oxidative damage in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay. Resp Health Eff Inst. 184:87-105, 2015  PMID: 25842617. 
  3. Aguilera-Aguirre L, Hosoki K, Bacsi A, Xsolt R, Wood TG, Widen SG, Sur S, Ameredes BT, Saavedra-Molina A, Brasier AR, Ba, X, Boldogh I.  Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes.  Free Radic Biol. Med.  Jan 19 pii: S0891-5849(15)00011-8. doi: 10.1016/j.freeradbiomed.2015.01.004. [Epub ahead of print] 2015 PMCID-In process. PMID: 25614460. 
  4. Sokol K, Sur S, Ameredes BT. Inhaled environmental allergens and toxicants as determinants of the asthma phenotype. Chapter 4 in: Heterogeneity in Asthma: Translational Profiling and Phenotyping, AR Brasier, ed., Advances in Experimental Medicine and Biology, Vol. 795, 43-74, XIV, 354 p. 33 illus., 25 illus. in color; Springer, New York, NY. E-book ISBN 978-1-4614-8603-9; Hardcover ISBN 978-1-4614-8602-2, 2014. 
  5. Ruiz, J, Ameredes, BT. The cellular effects of carbon monoxide in the airway. Curr Mol Med  13(1):94-108, 2013. 
  6. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske Jr RF, Lugogo N, Martin RM, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA Sept 12, 308(10): 987-997. 2012. 
  7. Ameredes, BT. Beta-2-receptor regulation of immunomodulatory proteins in airway smooth muscle. Frontiers in Bioscience (Schol Ed). 3:643-54, 2011. 
  8. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes, BT, Boushey HA, Calhoun WJ, Mario Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, Emily A. DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske, Jr., RF, Lugogo N, Martin, RJ, Meyers, DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network. Tiotropium bromide as add-on therapy in asthma: result of the ACRN’s TALC trial. N. Engl. J. Med. 363:1715-26, 2010. 
  9. Ameredes,BT. Translating airway biomarker information into practice: from theoretical science to applied medicine. Pulm Pharmacol Ther. Sep 30. [Epub ahead of print] 2010. 
  10. Ogawa Y, Duru EA, Ameredes BT. Role of IL-10 in the resolution of airway inflammation. Curr Mol Med. 8(5): 437-445, 2008. 

Link to NCBI my bibliography