Kangling Zhang
Kangling Zhang, Ph.D. Assistant Professor, Department Pharmacology and Toxicology

Contact Information:
Phone: (409) 772-9650
Fax: (409) 772-648
Email: kazhang@utmb.edu

Lab website

Education:
1998-2000         Ph. D., 2000, University of the Pacific 
                         (Major/Minor: Biochemistry/Mass Spectrometry)
1998-2000         Predoc. University of California at San Francisco
                         (Major: Mass Spectrometry)
1994-1997         M. S. 1997, University of the Pacific
                         (Major/Minor: Biochemistry/NMR)
1987-1990         M. S. 1990, East China University of Science & Technology 
                         (Major/Minor: Analytical Chemistry /Mass Spectrometry/)
1980-1984         B. S. 1984, Anhui University 
                         (Major/Minor: Chemistry/Analytical Chemistry) 

Research Interests:
Dr. Zhang was trained at UCSF Mass Spectrometry Facility under the direction of Dr. Alma Burlingame, the chief editor of the Journal of Molecular and Cellular Proteomics. His research interest focuses on the development of state-of-the-art methodologies in mass spectrometry and their applications in epigenetics, with the hope of better understanding the cause of diseases and cancer.  His current research is the study of one-carbon metabolism and histone methylation in hypoxic cancer cells by mass spectrometry and biochemistry.

Selected Publications:  

  1. Zhang K, Williams KE, Huang L, Yau P, Siino JS, Bradbury EM, Jones PR, Minch MJ, Burlingame AL. Histone acetylation and deacetylation: identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry. Molecular & cellular proteomics : MCP. 2002; 1(7):500-8. PMID:12239278 
  2. Zhang K, Yau PM, Chandrasekhar B, New R, Kondrat R, Imai BS, Bradbury ME.Differentiation between peptides containing acetylated or tri-methylated lysines by mass spectrometry: an application for determining lysine 9 acetylation and methylation of histone H3. Proteomics. 2004; 4(1):1-10. PMID:14730666 
  3. Xu F, Zhang K, Grunstein M. Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell. 2005; 121(3):375-85. PMID:15882620 
  4. Sridhar VV, Kapoor A, Zhang K, Zhu J, Zhou T, Hasegawa PM, Bressan RA, Zhu JK. Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination. Nature. 2007; 447(7145):735-8.PMID: 17554311 
  5. Horwitz GA, Zhang K, McBrian MA, Grunstein M, Kurdistani SK, Berk AJ. Adenovirus small e1a alters global patterns of histone modification. Science. 2008; 321(5892):1084-5. PMID:18719283 
  6. Liu B, Lin Y, Darwanto A, Song X, Xu G, Zhang K. Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. The Journal of biological chemistry. 2009; 284(47):32288-95. PMID: 19801601 
  7. Darwanto A, Curtis MP, Schrag M, Kirsch W, Liu P, Xu G, Neidigh JW, Zhang K. A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation. The Journal of biological chemistry. 2010; 285(28):21868-76. PMID: 20442396 
  8. Tang H, Fang H, Yin E, Brasier AR, Sowers LC, Zhang K. Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer. Analytical chemistry. 2014; 86(11):5526-34.PMID:24823915 
  9. Nicholas D, Tang H, Zhang Q, Rudra J, Xu F, Langridge W, Zhang K. Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation. Molecular & cellular proteomics : MCP. 2015; 14(1):15-29. PMID: 25316709 
  10. Sowers JL, Mirfattah B, Xu P, Tang H, Park IY, Walker C, Wu P, Laezza F, Sowers LC, Zhang K. Quantification of histone modifications by parallel-reaction monitoring: a method validation. Analytical chemistry. 2015; 87(19):10006-14. PMID: 26356480 

Link to NCBI mybiblography