09/1997 – 08/2003, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D. in Cell Biology, August, 2003
Mentor: Prof. Gang Pei
Dissertation: The study of the structure and function of G protein-coupled receptors
07/2000 – 10/2001, University of Louisville, Louisville, KY
Project: Mechanisms of CXCR4 activation
09/1993 – 06/1997, Yunnan University (Joint undergraduate of Fudan University, Shanghai), Kunming, P.R. China
B.S. in Biochemistry, June, 1997
The long-term research goal in my laboratory is to understand mechanisms of retinal injury in ischemic retinopathy such as diabetic retinopathy, retinopathy of prematurity and glaucoma. Our work includes three areas of the pathology of ischemic retinopathy: retinal neuronal injury, retinal vascular leakage and degeneration, and retinal pathological angiogenesis.
Our group is now assessing the involvement of ER stress and inflammatory cytokines in particular chemokines in the development and progression of above diseases. In addition to inflammation, we are elucidating novel mediators for pathological angiogenesis and using nanoparticle-mediated drug delivery to treat retinal neovascular diseases such as retinopathy of prematurity and proliferative diabetic retinopathy. Since retina is an extension of the brain, we also collaborate with investigators in the fields of neurodegenerative and infectious diseases such as Alzheimer’s diseases and Zika virus infection using eye as a window.