1978 A.B., Earlham College, Richmond, Indiana
1983 Ph.D., Duke University, Durham, North Carolina Physical Biochemistry
Postdoctoral fellow, Harvard University, Department of Medicine
Dana Farber Cancer Institute
His work has involved the chemistry and biology of DNA damage resulting from both carcinogens and cancer chemotherapy agents. More recently, he has focused upon damage to DNA resulting from reactive molecules generated by activated inflammatory cells including eosinophils and neutrophils. He has recently demonstrated how certain inflammation-mediated DNA damage products could mimic epigenetic signals, perhaps explaining how inflammation could result in heritable changes in genes expression important for the silencing of tumor suppressor genes in the development of cancer, and how early exposure to agents that trigger inflammation could influence disease susceptibility later in life. His laboratory has trained numerous Ph.D., M.D. and M.D./Ph.D. students over the years and he looks forward to training further students within the context of this translational and interdisciplinary program in Galveston.