Roberto Garofalo
Roberto P. Garofalo, M.D.Professor, Department of Pediatrics Vice Chair for Research, Department of Pediatrics Director, Division of Clinical and Experimental Immunology and Infectious DiseaseSealy Center for Molecular Medicine

Contact Information:
Phone: (409) 772-2658

Research Interests: 
Dr. Garafalo’s lab is generally focused on the macrophage inflammatory protein (MIP-1a), a chemokine produced by virally infected lungs. MIP-1a has potent activities on natural killer (NK) cells and cytotoxic T lymphocytes (CTL) that may function as a bridge between innate and adaptive immune responses to RSV infection. His lab seeks to 1) understand the contribution of MIP-1a in RSV-induced lung infection, 2) the role of MIP-1a in the migration and activation of NK cell-driven CTL responses in RSV infection, 3) to identify candidate proteins associated with the virus-induced airway pathology controlled by MIP-1, and 4) to determine with the use of high resolution proteomics whether and how mucosal protein patterns discriminate infants with different forms of illness.

Selected Publications: 

  1. Haeberle, H., Nesti, F., Dieterich, H., Gatalica, Z., Garofalo, R.P. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and NF-kB activation. Am J Respir Crit Care Med 2002; 165:1433-1438 
  2. Jartti, T., van den Hoogen, B., Garofalo, R.P., Osterhaus, A. DME, Ruuskanen, O. New human metapneumovirus and acute wheezing in children. The Lancet 2002;360:1393-1394 
  3. Welliver, R.C., Garofalo, R.P., Ogra., P.L. Beta-chemokines, but neither T helper type 1 nor T helper type 2 cytokines, correlate with severity of illness during respiratory syncytial virus infection. Ped Infect Dis J 2002;21:457-461. 
  4. Haeberle, H., Takizawa, R., Casola, A., Brasier, A.R., Hans-Juergen D., van Rooijen, R., Gatalica, Z., Garofalo, R.P. Respiratory syncytial virus-induced activation of NF-kB in the lung involves alveolar macrophages and Toll-like receptor 4-dependent pathways. J Infect Dis. 2002;186:1199-1206 
  5. Haeberle, H., Casola, A., Gatalica, Z., Petronella S., Dieterich, H.-J., Ernst, P.B., Brasier, A.R., Garofalo, R.P. The IkB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J Virol 2004;78:2232-41 
  6. Garofalo R.P., Hintz K.H., Hill V., Ogra P.L., Welliver R.C. Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. J Med. Virol 2004;73:289-294 
  7. Liu T, Castro S, Jamaluddin M, Brasier AR, Garofalo RP and Casola A. ROS mediate viral-induced Stat activation: role of tyrosine phosphatases. J Biol Chem 2004;279:2461-69 
  8. Brasier AR, Spratt H, Wu Z, Boldogh I, Zhang Y, Garofalo RP, Casola A, Pashmi J, Haag A, Luxon B and A Kurosky. Nuclear Heat Shock Response and Novel Nuclear Domain 10 Reorganization in Respiratory Syncytial Virus-Infected A549 Cells Identified By High Resolution 2D Gel Electrophoresis. J Virol 2004; 78:11461-11476. 
  9. Garofalo R.P., Hintz K.H., Hill V., Patti J., Ogra P.L., Welliver R.C. A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus. J Med. Virol in press.