Shakeel Ansari
Ghulam Ahmad Shakeel Ansari, Ph.D. 
Professor, Department of Pathology

Contact Information:
Phone: (409) 772-3655
Fax: (409) 747-1763

B.S. Aligarh Muslim University, Aligarh, IndiaChemistry 1966 
M.S. Aligarh Muslim University, Aligarh, India Chemistry 1969 
Ph.D. Aligarh Muslim University, Aligarh, India Chemistry 1973

Research Interests:
Dr. Ansari’s research interests lie principally in the area of molecular toxicology and systems biology. He uses biomarker signatures and metabolomics to study chemical-mediated liver injury and chemical-mediated autoimmunity.

    Selected Publications: 

    1. Cai, P., Konig, R., Boor, P. J., Kondragant, S., Kaphalia, B.S., Khan, M.F., Ansari, G.A.S. Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice. Toxicol. Appl. Pharmacol. 228:68-75, 2008.
    2. Konig, R., Cai, P., Guo, X., Ansari, G.A.S. Transcription analysis reveals early signs of liver toxicity in female MRL/mice exposed to the acylating chemicals dichloroacetyl chloride and dichloroacetic anhydride. J. Chem. Res. Toxicol. 21:572-582, 2008.
    3. Cai, P., König, R., Khan, M.F., Kaphalia, B.S., Ansari, G.A.S. Differential immune responses to albumin adducts of reactive intermediates of Trichloroethene in MRL +/+ mice. Toxicol. Appl. Pharmacol. 220:278-283, 2007.
    4. Wu, H., Cai, P., Clemens, D.L., Jerrells, T.R., Ansari, G.A.S., Kaphalia, B.S. Metabolic basis of ethanol induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism. Toxicol. Appl. Pharmacol. 216:238-247, 2006.
    5. Sharma, R., Ansari, G.A.S. and Awasthi, Y.C. Physiological substrates of glutathione S-transferases. “Toxicology of Glutathione Transferases,” Chapter 9 (Y.C. Awasthi, Editor), CRC Press (2006).
    6. Cai P., Kaphalia, B.S., Ansari, G.A.S. Methyl palmitate: Inhibitor of phgocytosis in primary rat Kupffer Cells. Toxicology, 210:197-204, 2005.
    7. Mericle, K.A., Kaphalia, B.S., Ansari, G.A.S. Modulation of fatty acid methyl esters in rats pre-treated with tri-o-tolyl phosphate. J. Toxicol. Environ. Health, Part A 67:583-593, 2004.
    8. Green, S.M., Khan, M.F., Kaphalia, B.S., Ansari, G.A.S. Immnohistochemical localization of protein adducts of tetrachloreoethene in mice. J. Toxicol. Environ. Health 63: 145-157, 2001.
    9. Kaphalia BS, Fritz RR and Ansari GAS. Purification and characterization of rat liver microsomal fatty acid ethyl and 2-chloroethyl ester synthase and their relationship with carboxylesterase (Pl 6.1). Chem. Res. Toxicol. 10:211-218, 1997.
    10. Awasthi YC, Zimniak P, Awasthi S, Singhal SS, Srivastava SK, Piper JT, Chaubey M, Petersen DR, He N, Sharma R, Singh SV, Khan FM, Ansari GAS, Boor PJ. A new group of glutathione S-transferase with protective role against lipid peroxidation. Glutathione s-transferases: structure, function and clinical implications. (Vermeulen et al., editors; Taylorand Francis, 1996) pages 111-124.