Division of Rehabilitation Sciences

Associate Professor Monique Pappadis, MEd, PhD presented a keynote address, "Educating Families and Patients with Traumatic Brain Injury (TBI): Are We Doing Enough?" at the Annual Council on Brain Injury Conference. on April 9, 2019 at Duquesne University in Pittsburgh.

A new scientific journal article has been published, Data Science in Physical Medicine and Rehabilitation: Opportunities and Challenges, by Division Director Ken Ottenbacher, PhD, OTR and colleagues James Graham, PhD, DC, Professor of Occupational Therapy and Director of the Center for Community Partnerships (CCP) from Colorado State University and Steve Fisher, PhD, Associate Professor in the Department of Physical Therapy at UTMB.

Key points

• Data science represents a new approach to developing knowledge in biomedical research.
• Data science is producing innovative ways to acquire, store, analyze, and interpret large amounts of diverse medical and health-related information.
• The implementation of data science will enhance the ability of physical medicine and rehabilitation to reduce disability and improve health care services and outcomes.

A new paper, A Phase I Randomized Clinical Trial of Evidence-Based, Pragmatic Interventions to Improve Functional Recovery After Hospitalization in Geriatric Patients, in the Journal of Gerontology: Medical Sciences shows potential new ways to speed up recovery from the hospital. UTMB researchers, led by Elena Volpi, MD, PhD, tried different strategies to boost the function of older adults hospitalized for an acute illness. Read press release from Sealy Center on Aging.

This article was the result of a pilot study performed in the Acute Care for Elders Unit at UTMB.

Lead author Rachel R. Deer, PhD is an Assistant Professor, Division of Rehabilitation Sciences at UTMB. She also has appointments in the Division of Nutrition and Metabolism and the Graduate School of Biomedical Sciences. Dr. Deer is an RL5 Scholar in the UTMB Claude D. Pepper Older American Independence Center. Her research focuses on interventions to accelerate functional recovery from hospitalization in older adults.

Congratulations on new publication, Skeletal Muscle Specific Knockout of DEP Domain-Containing 5 Increases mTORC1 Signaling, Muscle Cell Hypertrophy, and Mitochondrial Respiration by Ted G. Graber, Christopher S. Fry, Camille R. Brightwell, Tatiana Moro, Rosario Maroto, Nisha Bhattari, Craig Porter, Maki Wakamiya and Blake B. Rasmussen.

In this study, we knocked out the gene for DEPDC5, which is a subunit of the GATOR1 protein complex (a negative regulator of mTORC1—the master regulator of protein synthesis), in adult skeletal muscle in mice. GATOR1 shuts off protein synthesis in the cell when there are insufficient amino acids present. When we depleted DEPDC5, we determined a constitutive activation of mTORC1 leading to muscle hypertrophy increased mitochondrial respiration without functional improvements. Thus, we uncovered a role for DEPDC5/GATOR1 in the regulation of mitochondrial respiration, hinting that amino acid sensing apparatus in the cell may be more involved in metabolic programming than previously thought

Dr. Graber is a member of the Muscle Biology Laboratory team in the Center for Recovery, Physical Activity, and Nutrition and a postdoctoral trainee in the Division of Rehabilitation Sciences at UTMB.

Rehabilitation Sciences PhD Student Julianna Bores, MS has authored her first, first-author publication, "Use of Isokinetic Dynamometry to Assess Muscle Function in Burned Patients is a Reliable Tool to Assist Progressive Resistance Exercise Prescription." Congrats, Julianna!

Rehabilitation Sciences Assistant Professor Brian Downer, PhD is the recipient of a K01 Grant, "Improvement in Patients’ Cognition and Relationship with SNF Quality Measures." from the National Institute on Aging of the NIH. Congratulations, Dr. Downer!