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Bill T. Ameredes, MS, PhD

Professor, Division of Pulmonary Critical Care & Sleep Medicine
Biochemistry & Molecular Biology; Pharmacology and Toxicology
William C. Levin Chair, Environmental Toxicology
Director, NIH/NCATS KL2 Scholar Program
Director, Inhalation Toxicology Core
Director, NIEHS Environmental Toxicology Training Program
Sealy Center for Molecular Medicine

Bill T. Ameredes, MS, PhD

Phone: (409) 772-8104

Research Interests

The role of environmental toxicants, such as gaseous and particulate air pollutants, in promoting airway inflammation, hyperresponsiveness, and remodeling may be important in the development of asthma and chronic obstructive pulmonary disease.

As the Director of the Environmental Inhalation Exposure Facility at UTMB, I am interested in inhaled agents, including sulfur dioxide, carbon monoxide, ozone, diesel and other particulates, VOCs, allergens, and cigarette smoke. Recent work has focused on airway effects of combinations of toxicants such as cigarette smoke and SO2. We are also interested in mechanisms and resolution of allergic rhinosinusitis, and non-invasive imaging techniques for assessment of upper and lower airway changes in a variety of airway diseases.

Selected Publications
  1. Bing T, Patrikeev I, Ochoa L, Vargas G, Belanger KK, Litvinov J, Boldogh I, Ameredes BT, Motamedi M, Brasier AR. NFκB mediates mesenchymal transition, remodeling and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns. Amer J Resp Cell Molec Biol. Apr;56(4):506-520, 2016.

  2. Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, Macmillion-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in collaborative cross mice. Toxicology  Mar 1;378:114-124. doi: 10.1016/j.tox.2017.01.005,  2017.

  3. Hallberg LM, Ward JB, Wickliffe JK, Ameredes BT. ACES Auxiliary Findings on 2007-compliant Diesel Engines: a Comparison with Diesel Exhaust Genotoxicity Effects Prior to 2007. Environmental Health Insights Volume 11: 1–13, 2017.

  4. Sethi JM, Choi AMK, Calhoun WJ, Ameredes BT. Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice. Respir. Res. 9:45, 2008. PMCID2474844

  5. Levy BD, Marigowda G, Erzurum SC, Dweik RA, Comhair SA, Lara AR, Khatri S, Baaklini M, Laskowski D, Sharp J, Teague WG, Fitzpatrick AM, Chung KF, Hew M, Meah S, Wenzel SE, Calhoun WJ, Ameredes BT, Gaston B, Busse WW, Jarjour N, Swenson C, Bleecker ER, Meyers D, Moore W, Peters S, Hastie A, Hawkins G, Castro M, Bacharier L, Hussain I, Tarsi J, Curran-Everett D, Noel P. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. J Allergy Clin Immunol. 124(5):990-6.e1-9, 2009. PMCID2776730

  6. Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske Jr., RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman S, Israel E.  Effect of beta2-adrenergic receptor polymorphism on response to long-acting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomized, placebo-controlled, crossover trial. The Lancet. 374(9703):1754-1764, 2009. PMCID2914569

  7. Ameredes, BT. Translating airway biomarker information into practice: from theoretical science to applied medicine. Pulm Pharmacol Ther. 24:187-192, 2011

  8. Ameredes, BT. Beta-2-receptor regulation of immunomodulatory proteins in airway smooth muscle. Frontiers in Bioscience (Scholar Edition). 3:643-54, 2011

  9. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes, BT, Boushey HA, Calhoun WJ, Mario Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, Emily A. DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske, Jr., RF, Njira Lugogo, Martin, RJ, Meyers, DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network. Tiotropium bromide as add-on therapy in asthma: result of the ACRN’s TALC trial. N. Engl. J. Med. (In press)
  10. Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK. Advanced Collaborative Emissions Study (ACES) Subchronic exposure results: biologic responses in rats and mice and assessment of genotoxicity. Part 3. Assessment of genotoxicity and oxidative stress after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: Report on 1- and 3-month exposures in the ACES bioassay. Res Rep Health Eff Inst., (166): 163-184, 2012.

  11. Ruiz, J, Ameredes, BT. The cellular effects of carbon monoxide in the airway. Curr Mol Med   13(1):94-108, 2013.

  12. Devekar, R., Ameredes BT, Calhoun WJ. Symptom-based controller therapy: a new paradigm for asthma treatment. Curr Allergy Asthma Reports Oct;13(5): 427-33. doi: 10.1007/s11882-013-0375-7, 2013.

  13. Sokol K, Sur S, Ameredes BT. Inhaled environmental allergens and toxicants as determinants of the asthma phenotype. Chapter 4 in: Heterogeneity in Asthma: Translational Profiling and Phenotyping, AR Brasier, ed., Advances in Experimental Medicine and Biology, Vol. 795, 43-74, XIV, 354 p. 33 illus., 25 illus. in color; Springer, New York, NY. E-book ISBN 978-1-4614-8603-9; Hardcover ISBN 978-1-4614-8602-2, 2014.