Dr. Lu is a Professor at the Department of Preventive Medicine and Population Health, School of Medicine, and has a joint appointment at Department of Nutrition and Metabolism at School of Health Profession. With a training in pharmacy and medicinal chemistry, she was the first to discover that the methylation at the 5-position of cytosine in nucleic acids can be inhibited by an antileukemic drug, 5-azacytidine. She has found that fetal tissues have the ability to metabolize environmental chemicals to induce DNA adducts which may be involved in transplacental and chemical carcinogenesis. Her most recent major research interest, however, is the prevention of breast cancer through dietary means. She have been studying the effects of soy isoflavones on biomarkers that are risk indicators of several chronic diseases such as mammographic density for breast cancer, blood pressure for cardiovascular diseases, and bone mineral density for osteoporosis. She chose to study soy effects in premenopausal women anticipating that application of soy diets to populations required a life-long exposure. She and her interdisciplinary team have investigated the potential health effects of soy through controlled feeding studies on a metabolic unit and randomized double-blind, placebo-controlled clinical trials on ambulatory subjects. Her team found and proposed that soy isoflavones may be a new class of compounds participated in calcium homeostasis. She and her team continue to research the molecular and endocrine mechanisms that soy isoflavones may be used to improve population health.

Curriculum Vitae - CV

• BS, Pharmacy, National Taiwan University, Taiwan, 1968
• PhD, Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, 1972

• Breast cancer prevention: Dietary intervention to improve population health
• Biological effects of soy isoflavones in women
• Small molecules and proteins as biomarkers for breast cancer risk
• Explore naturally present and synthesize selective estrogen receptor modulators for prevention of primary and secondary breast cancer
• Explore naturally present and synthesize calcium mimetics for prevention of cardiovascular diseases

• Department of Preventive Medicine and Population Health
• Department of Nutrition and Metabolism
• Graduate School of Biomedical Sciences
• Cancer Center
• Institute for Translational Sciences
• Center for Interdisciplinary Research in Women's Health
• Sealy Center for Environmental Health and Medicine