Vaccines for the 21st Century is a five-week
introductory course designed to provide the basic scientist with an
understanding of vaccine development from conceptualization through development,
testing and utilization. The course Objectives are to learn:
- The
history of the development of vaccines and their impact on society.
- The
identification of pathogens & diseases for which vaccines are needed.
- The
principles of the development, availability and use of vaccines.
- The
pathophysiologic approach to developing vaccine strategies.
- The
application of traditional and new technologies to vaccine development.
- The
importance of the regulatory process to vaccine development, including
“proof of principle”, preclinical and clinical testing.
The
course will be taught in lecture format with a small number of expert lecturers.
There will be assigned reading in preparation for each session. Reading
materials will be provided. Each session will be 1 hour (total 15 contact
hours). Course performance will be determined by take home midterm & final
examinations (50% each).
Course Outline
An introduction to
vaccinology:
1.
The history of the prevention of disease using vaccines
2.
The immune responses to the pathogen & vaccine development
3.
Antigen and Vaccine Delivery Strategies
4. Getting to licensure can be a complex process
5.
The biology of adverse events
6.
Determinants of Vaccine Availability
Strategies
for vaccine development:
7.
Vaccine Development Strategies: Understanding diseases pathophysiology.
8.
Pathophysiology and a vaccine under development: HSV
9.
Vaccine Development: Helicobacter pylori
10.
Vaccine Development: Encephalitides:
Japanese Encephalitis &
West Nile Viruses.
11.
Vaccine Development: Dengue and Dengue Hemorrhagic Fever
12.
Vaccine Development: intracellular bacteria
The Future:
13. Adjuvants.
14.
Vaccine development strategies: new approaches
15.
Vaccines for the future
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