The research in my laboratory has focused on viral pathogenesis, vaccine development and on development of animal models to test new vaccine candidates and antiviral drugs. My main research interest is in understanding the mechanisms by which emerging RNA viruses cause encephalitis, hemorrhagic fever or respiratory diseases. Central nervous system (CNS) invasion by RNA viruses is particularly a complex and fascinating process. We seek to elucidate the nature of the neuroinflammatory response to CNS invasion by viruses in diverse families such as Togaviridae, Orthomyxoviridae, Bunyaviridae and Arenaviridae. Our approach is designed to provide expertise for the development and evaluation of vaccines and anti-viral drugs in collaboration with partners in academia (within and between institutions), in biotechnology and in federal agencies.