Robin Stephens, PhD
Malaria still kills 0.8 million people a year, mostly children in sub-Saharan Africa. Vaccine work has entered a very hopeful stage, but very little is known about the factors determining immunity to this parasitic disease. Work in our laboratory focuses on the immunology and pathology of malaria infection. CD4+ Memory T and B cells are essential for effective immunity, however there are many aspects of their development and maintenance that are not yet understood. Our aim is to understand the mechanisms of protection and maintenance of these cells.
- CD4+ T cell memory to blood stages of Plasmodium chabaudi chabaudi (AS), mouse malaria
- Effector function (Th1, Tfh) commitment in memory cells in malaria
- Vaccine strategies to generate protective effector memory T cells
- B cell memory and splenic microenvironment
- T cell memory and cytokines in P. Falciparum infection in collaboration with field laboratories
- Techniques: Multi-color flow cytometry, microchip analysis, in vivo studies
Stephens R, Langhorne J. Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria. PLoS Pathog. 2010 Nov 24;6(11):e1001208.
- Stephens R, Langhorne J. Priming of CD4+ T cells and development of CD4+ T cell memory; lessons for malaria. Parasite Immunol. 2006 Jan-Feb;28(1-2):25-30. Review.
- Stephens R, Albano FR, Quin S, Pascal BJ, Harrison V, Stockinger B, Kioussis D, Weltzien HU, Langhorne J. Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance. Blood. 2005
Sep 1;106(5):1676-84. Epub 2005 May 12.
Search PubMed for Dr. Stephens' publications.