My current research is on the epidemiology and pathogenesis of a variety of arthropod-transmitted and rodent-associated viral diseases. It includes both field and laboratory studies. Since many of the diseases that we study are zoonoses, part of my work involves field studies of virus ecology and transmission dynamics in endemic regions of tropical South America. We have also recently developed animal (hamster) models for yellow fever, West Nile encephalitis and arenaviral hemorrhagic fever. These models are now being used in laboratory-based studies to elucidate the pathogenesis of the respective viruses and to develop strategies for their treatment and control, including evaluation and development of effective vaccines. Dr. Tesh is also the Director of the World Reference Center for Emerging Viruses and Arboviruses.