My research focuses on understanding of immune response to West Nile virus infection in protection and pathogenesis. West Nile virus, a vector-borne pathogen, has resulted in annual outbreaks of viral encephalitis in North America since 1999. Human vaccines are not yet available. Using a murine infection model, my current work explores immune factors contributing to the development of long-lasting protective immunity against West Nile virus. Aging is a known risk factor for West Nile virus induced encephalitis. We also attempt to understand immune factors that could lead to a defective adaptive immunity in aged mice in order to evaluate new strategies in WNV vaccine development for the more susceptible aging population.