The UTMB Pepper Center Claude D. Pepper Older Americans Independence Center (OAIC)
The UTMB Claude D. Pepper Older Americans Independence Center (OAIC),
currently directed by
Elena Volpi, MD, PhD, has been continuously funded since 2000. Our Center nurtures a multidisciplinary translational research culture to fulfill our mission, which is to improve physical function and independence in older adults. Central to this mission is the career development and training of the next generation of leaders in geriatric research. Our scientific focus has evolved over the years from a narrow interest in the mechanisms of sarcopenia to the translation of our findings in patient-centered interventions to improve physical function and independence in older adults.
The Pepper Center at UTMB has recently been refunded through 2020 by a $3.4 million grant from the National Institute on Aging. Read more about us.
Pepper Center News
UTMB Researchers Seek to Block the Process of Muscle Wasting with Age
By SCoA | April 10, 2019
By age of 60, 30% of US adults will suffer from sarcopenia, characterized by clinically recognizable chronic muscle degeneration manifesting as extreme fatigue, weakness, and greatly reduced physical activity. To combat this decline, UTMB investigators Drs. Stanley Watowich and Christopher Fry received funding for an innovative study of drugs to block the molecular processes involved. Read more about the new study, Development of NNMT inhibitors as novel interventions to activate quiescent muscle stem cells and improve age-related muscle degeneration.
Dr. Fry is a Core Investigator at the Sealy Center on Aging and co-leader of the Metabolism and Biology Resource Core in the UTMB Pepper Center.
Pepper Scholar Presents Keynote on Traumatic Brain Injury
By SCoA | April 10, 2019
RL5 Scholar Monique Pappadis, MEd, PhD presented a keynote address, "Educating Families and Patients with Traumatic Brain Injury (TBI): Are We Doing Enough?" at the Annual Council on Brain Injury Conference. on April 9, 2019 at Duquesne University in Pittsburgh.
UTMB Researchers Help Older Patients Recover Better
By SCoA | April 1, 2019
A new paper, A Phase I Randomized Clinical Trial of Evidence-Based, Pragmatic Interventions to Improve Functional Recovery After Hospitalization in Geriatric Patients, in the Journal of Gerontology: Medical Sciences shows potential new ways to speed up recovery from the hospital. UTMB researchers, led by Elena Volpi, MD, PhD, tried different strategies to boost the function of older adults hospitalized for an acute illness. Read press release from Sealy Center on Aging.
This article was the result of a pilot study performed in the Acute Care for Elders Unit at UTMB.
Lead author Rachel R. Deer, PhD is an Assistant Professor, Division of Rehabilitation Sciences at UTMB. She also has appointments in the Division of Nutrition and Metabolism and the Graduate School of Biomedical Sciences. Dr. Deer is an RL5 Scholar in the UTMB Claude D. Pepper Older American Independence Center. Her research focuses on interventions to accelerate functional recovery from hospitalization in older adults.
New Publication on Improving Muscle in Older Adults
By SCoA | February 7, 2019
Doctoral Student Camille Brightwell is the first author on a new publication, "Moderate Intensity Aerobic Exercise Improves Skeletal Muscle Quality in Older Adults," in Translational Sports Medicine. Additional co-authors include M.M. Markofski, T. Moro, C.S. Fry, C. Porter, E. Volpi, and B.B. Rasmussen.
Camille is a current trainee in the Pre and Postdoctoral TrainingT32 - Health of Older Minorities program at the Sealy Center on Aging. She is also a member of the Muscle Biology Laboratory affiliated with the Center for Recovery, Physical Activity and Nutrition.
New study finds that correct amounts of protein during inactivity helps protect muscle mass
By UTMB Newsroom | January 30, 2019
GALVESTON, Texas – A new research study suggests that improving the quality of protein people eat while on bed rest could actually help protect muscle mass and burn fat.
“When a person is restricted to bed rest, even for a few days, they typically lose muscle and gain fat,” said Dr. Douglas Paddon-Jones, a professor at UTMB and senior author of the study. “Simply eating more food and protein may help protect muscle, but will likely increase body fat. Conversely, eating less food may help avoid fat gain, but will accelerate muscle loss. In this study, we were interested in finding a pragmatic, practical approach to help deal with this issue.” Read more at the UTMB Newsroom.
Read the article in the Journals of Gerontology, Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function by Emily J Arentson-Lantz, PhD, Elfego Galvan, RD, PhD, Jennifer Ellison, PT, PhD, Adam Wacher, MD, and Douglas Paddon-Jones, PhD.
By UTMB Provost's Office | January 25, 2019
When the Sealy Center on Aging initiated its winter lecture series 24 years ago, it was the perfect opportunity to honor the vision of Dr. Edward James Lefeber. The late UTMB Professor of Medicine had been a strong proponent of elder care and the study of aging at a time when few doctors were prepared to care for older patients. Read more about the Lefeber Winter Series in this article from the UTMB Provost's Office.
Lectures will be held each Tuesday evening beginning at 5pm January 29th through February 26th, 2019.
By Washington Post | January 19, 2019
There is a growing consensus that as people age they need to eat more protein-rich foods, particularly when dealing with a chronic or acute illness, or facing a hospitalization. During these stressful times, aging bodies process protein less efficiently and need more of it to maintain muscle mass. UTMB’s Elena Volpi said it is not just the total amount of protein one eats, but also how much they eat at a given meal.
“If I eat too little protein during a meal, I may not adequately stimulate the uptake of amino acids into skeletal muscle. If I eat too much, say from a large T-bone steak, I won’t be able to store it all away,” Volpi said.
New Metabolism Publication
By SCoA | January 17, 2019
New publication, "Skeletal Muscle Specific Knockout of DEP Domain-Containing 5 Increases mTORC1 Signaling, Muscle Cell Hypertrophy, and Mitochondrial Respiration" by Ted G. Graber, Christopher S. Fry, Camille R. Brightwell, Tatiana Moro, Rosario Maroto, Nisha Bhattari, Craig Porter, Maki Wakamiya and Blake B. Rasmussen.
“In this study, we knocked out the gene for DEPDC5, which is a subunit of the GATOR1 protein complex (a negative regulator of mTORC1—the master regulator of protein synthesis), in adult skeletal muscle in mice. GATOR1 shuts off protein synthesis in the cell when there are insufficient amino acids present. When we depleted DEPDC5, we determined a constitutive activation of mTORC1 leading to muscle hypertrophy increased mitochondrial respiration without functional improvements. Thus, we uncovered a role for DEPDC5/GATOR1 in the regulation of mitochondrial respiration, hinting that amino acid sensing apparatus in the cell may be more involved in metabolic programming than previously thought.”
Call for Pilot Project Applications
By SCoA | January 11, 2019
The UTMB Claude D. Pepper Older Americans Independence Center encourages UTMB investigators to submit pilot research proposals in the area aging, physical function and recovery from illness in older adults. Proposals from any domain of translational research (T1-T4) are welcome. Projects will be funded for one year, with total annual direct costs not to exceed $50,000.
Areas of research include but are not limited to: basic science, clinical trials, patient-centered outcomes, and population health. Learn more.
New Grant on Cognition & Quality of Skilled Nursing Facilities
By SCoA | January 11, 2019
Rehabilitation Sciences Assistant Professor Brian Downer, PhD is the recipient of a K01 Grant, "Improvement in Patients’ Cognition and Relationship with SNF Quality Measures." from the National Institute on Aging of the NIH. Dr. Downer is a Core Research Investigator at the Sealy Center on Aging and a Pepper Center Scholar. Congratulations, Dr. Downer!