Structure, expression, and disease
Our lab’s field of research is genome organization, and how it may drive, or be driven by changes in gene expression. Our overarching goal is to modulate gene expression by changing the DNA sequence, so it affects the 3D structure of chromatin, which serves as a mechanism to regulate gene expression.
To that end we are using a variety of cutting-edge imaging technologies, molecular genetics, and computational approaches. With these single-cell technologies we are investigating how genome organization might be associated with transcriptional activity, and how together, they could influence cell fate.