After completing his PhD in Molecular and Cellular
Biology at the University of Massachusetts, Dr. Holbrook moved to Dr. Alan
Barrett’s laboratory at UTMB.
At UTMB, his work had several foci that included from virus sequencing,
development of antiviral, structural virology and viral pathogenesis.
Following post-doctoral training, he moved to a faculty position at the
University of New Mexico but was recruited back to UTMB to become
director of the new BSL-4 facilities. In addition to faculty
responsibilities, Dr. Holbrook also took on the role of Director of Emerging and
High Risk Pathogens Core in the Galveston National Laboratory which
included the new BSL-4 facilities. Dr. Holbrook developed projects studying
tick-borne flaviviruses, yellow fever virus, Rift Valley fever virus,
Nipah virus and Ebola virus. These projects included structural studies,
drug development and evaluating mechanisms of viral pathogenesis with a
focus on innate immunity. Dr.
Holbrook is the former director of the Shope BSL-4 laboratory and the
emerging and high-risk pathogens core at the Galveston National
Laboratory at UTMB and was an
associate professor in the Department of Pathology. In 2009 he moved to a position at the National Institute of Allergy and Infectious Diseases (NIAID) Integrated Research Facility (IRF)
in Frederick, MD.
Dr. Holbrook is a senior scientist at the IRF and also serves as the
high-containment supervisor with responsibility for overseeing all
research activities within the Biosafety Level (BSL)l-4 facility. Dr. Holbrook’s work has included the development of
diagnostic agents as well as the testing of a number of different
vaccines and chemotherapeutic agents against BSL-3 and BSL-4 viruses, in
addition to extensive research experience in viral pathogenesis, viral
immunology, viral protein expression and characterization, viral
structure, and molecular virology. Dr. Holbrook has served as principal
investigator, co-investigator, and consultant on a number of National
Institutes of Health-supported grants and contracts.
Search PubMed for Dr. Holbrook's publications.