Patricia V. Aguilar, PhD

My research is focusing on understanding the molecular mechanisms of pathogenesis of emerging arboviruses. In particular, we are investigating how arboviruses evade host innate immunity to establish infection. Through these studies, we have identified a novel viral immune evasion mechanism involving the sequestration of multiple components of the RIG-I signaling pathways into bunyavirus-induced cytoplasmic structures.

The other major focus of my research is the investigation of host immune responses to arbovirus infection. We have investigated the natural immune responses to alphavirus infection and defined signatures of protection and disease severity.

The ultimate goal of our studies is to facilitate the rational development of vaccines and antivirals against emerging arboviruses.

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