Research
in my group investigates host-virus interactions and antiviral T cell
immunity in HIV infection and vaccination. In particular, we are
investigating how memory CD4 T cells specific to different pathogens or
antigens are differentially infected by HIV and how this is related to
reactivation of opportunistic infections in AIDS patients; on the basis
of this research, we are also interested in understanding how HIV may
differentially establish latent infection in different antigen-specific
memory CD4 T cell populations. The other major focus of our research is
on HIV vaccine immunology. We are utilizing a range of systems,
including cell culture, animal models (non-human primate/humanized
mouse) and specimens from human vaccine trials, to explore how
recombinant viral vectors (such as adenovirus, poxvirus and herpes
virus) impact the property of HIV vaccine-induced CD4 T cell responses
and how this affects the outcomes of HIV vaccination with regards to
protection and risk of HIV acquisition in vaccine recipients.
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