In my laboratory we are interested in the development of in vivo models
to explore the pathogenesis of infectious diseases and their use to
evaluate strategies for disease prevention and treatment. One of our
principle areas of interest has been genital and neonatal Herpes simplex
virus infection. We are continuing to explore the pathogenesis of these
infections as well as conducting research on vaccines and
chemoprophylactics for their prevention and antiviral agents for their
treatment. As part of our research on the use of chemoprophylactics to
protect the vaginal epithelium, we have also begun studies with an
important bacterial pathogen Chlamydia trachomatis. In addition we have used in vivo models to explore a number of congenital infections of clinical importance including cytomegalovirus and toxoplasmosis.
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