Matt Makowski earned a B.S. in Electrical Engineering and a Ph.D. in Biomedical Engineering from Purdue University and an M.D from Indiana University. His Internal Medicine residency was completed at Indiana University where he served an additional year as Chief Resident of Quality and Safety. Fellowship training took place at Duke University in Pulmonary and Critical Care Medicine as well as Undersea and Hyperbaric Medicine where he trained to conduct research in respiratory physiology, decompression sickness risk mitigation, and mechanisms of pulmonary and central nervous system oxygen toxicity. Due to his lifelong interest in spaceflight, he completed an Aerospace Medicine residency at UTMB.
He is now a principal investigator in the NASA Extravehicular Activity and Environmental Physiology Laboratory where his research aims to reduce the risk of decompression sickness on the lunar surface. His clinical responsibilities include serving as a medical officer at the NASA Neutral Buoyancy Laboratory and rounding in the Intensive Care Unit at UTMB. In 2026 he joined the faculty of the UTMB Department of Aerospace & Exploration Medicine to start the new Undersea and Hyperbaric Medicine Fellowship.