thumbnail_Ekta

August 2023 Spotlight: Dr. Ekta Singh

I pursued my PhD in biomedical engineering from the Indian Institute of Technology Bombay. The focus of my research was on developing trigger-responsive drug-loaded contrast agents for intra-articular imaging and therapy.

My current research as a postdoctoral fellow involves working with Low frequency Ultrasound (LFU) and its therapeutic effects. Under the mentorship of Prof. Michael P Sheetz, our research group has demonstrated the potential of LFU in rejuvenating senescence phenotype in cells as well as in old-aged animals. As a part of this research group, I am looking at the beneficial molecules that are secreted into the medium by normal cells, when treated with LFU. What makes these molecules interesting and worth exploring is that when senescent cells are treated with conditioned medium from LFU treated normal cells, there is a reduction in their senescent phenotype. The second project I am working on is studying the immediate as well as long term effects of LFU on the oral glucose tolerance, pancreatic senescence as well as physical performance in old aged high fat diabetic mice. Our preliminary data has shown evidence of an improved oral glucose tolerance and insulin response after treatment with LFU in this diabetic cohort of mice. Another interesting project I am working on is studying the effects of mechanical stimulation via LFU on the healing of full thickness cutaneous wounds in old-aged mice. Being in the early research transition phase, I am very excited to see what novel insights our research group will unveil heading towards in the area of mechanotherapy.

I am an aspiring academician and passionate about developing new teaching designs and effective mentorship. When I am not with my micropipette or laptop, I love singing alone with my Ukulele. I am very fond of traveling to countryside locations and food photography. I like to maintain a healthy and balanced lifestyle. A key trait of my personality is that I bond very closely with my family and friends.

Categories