Three Dimensional Structures of Viruses Determined by CryoEM: Past, Present, and Future
by Dr. Jack Johnson, The Scripps Research Institute
Super-Resolution Microscopy:Discovering How Molecules Work In Vivo
by Linda Kenney PhD, Edna Hu PhD, Felix Margadant PhD and Michael Sheetz PhD
Broad ebolavirus and Lassa virus neutralization: key sites and engineering for improved activity
by Dr. Erica Ollman Saphire
Developments toward the pharmacological management of glioblastoma
by Dr. Lawrence Sowers
Our lab’s journey to inhibit Alphavirus assembly
by Dr. Tuli Mukhopadhyay
Placental-maternal-fetal communication via packaged molecular signals
by Dr. Yoel Sadovsky
Balancing X chromosome Dosage: Mechanistic Insights and Impact on Cancer
by Dr. Eda Yildirim
Assembly, maturation and infectivity of flaviviruses
by Dr. Richard Kuhn
RNA Processing and the Human Immune System - a story of CELF control
by Dr. Kristen Lynch
The Multifaceted Roles of Adipocytes: Therapeutic Targets for Diabetes and Beyond
by Dr. Philip Scherer
G Protein-Coupled Receptor Biased Signaling Illustrated at Multiple Levels
by Dr. Jeffrey Liu
Boosting Metabolism with Nicotinamide Riboside: Full Circle From Milk
by Dr. Charles Brenner
Regulation and Function of Kisspeptin Neurons: lessons from mouse models
by Dr. Shannon Stephens
RNA virus mutation rates, another spandrel?
by Dr. Adam Lauring
Glucocorticoids, Allostery and Apoptosis
by Dr. E. Brad Thompson
The Henipavirus Cell Entry Machinery: from Structure to Function
by Dr. Joyce Wong
Roles and mechanisms of human translesion synthesis DNA polymerases
by Dr. Satya Prakash
Phosphoinositides, actin and DNA repair: Roles of nuclear phosphoinositides in early DNA damage signaling
by Dr. Yu-Hsiu (Eric) Wang
A New Temporal Model for EBV-Mediated B-Cell Transformation
by Dr. Micah Luftig
Epigenetic Regulation of Cancer Driver Genes
by Wei Li, PhD, Baylor College of Medicine
Role of cell to cell communication in NeuroHIV and Cancer
by Eliseo Eugenin. PhD, UTMB
Outsmarting Outbreaks – Using Genomics to Track Viruses
by Kristian Andersen, PhD, The Scripps Research Institute
Discovery and Development of Remdesivir, a Broad-spectrum Small Molecule Antiviral
by Tomas Cihlar, PhD, Gilead Sciences
RNA toxicity induces post-translational dysregulation in myotonic dystrophy
by Guey-Shin Wang, PhD, Institute of Biomedical Science, Taipei, Taiwan
Engineered phage tail-like bacteriocins for human therapeutics
by Dean Scholl, PhD, AvidBiotics
Poly(ADP-ribose) polymerase enzymes: structure, regulation, and inhibition
by John Pascal, PhD, U. de Montreal
Defective RNA virus genomes: passive interference or programmed enhancement?
by Andrew Routh, PhD, UTMB
Negative Regulation of Paused RNA Polymerase II: The value of a pair of scissors
by Eric Wagner, PhD, UTMB
Circadian regulation of cardiac remodeling
by Lilei Zhang, MD, PhD, Baylor College of Medicine
Bacterial Methylomes
by Rich Roberts, PhD, New England Biolabs Adrian R. Krainer, PhD, Cold Spring Harbor Laboratory
How do flaviviruses find their own RNA genome for viral replication?
by Kay Choi, PhD, UTMB
Mechanisms that influence splicing decisions
by Manny Ares, PhD, UC Santa Cruz
Genomic dissection of metastatic breast cancer tumors
by Jeffrey Chang, PhD, UT Health Science Center Houston
Dynamin function: Looking under and away from the lamp-post
by Sandra Schmid, PhD, UT Southwestern Medical Center
Tissue Specific Interferon Regulation and Effects on Influenza Virus Pathogenesis
by Nicholas S. Heaton, PhD, Duke University Medical Center
Using supercoiling, sequence, and curvature to create nanoparticle DNAs for gene therapy
by Lynn Zechiedrich, PhD, Baylor College of Medicine
Studying SNARE - mediated membrane fusion at the single vesicle level
by Jiajie Diao, PhD, University of Cincinnati
The core scaffolding of nucleotide excision repair machinery: From molecular mechanism to personalized medicine
by Walter J Chazin, PhD, Vanderbilt University
Both cellular and flaviviral specific factors determine the mode of induction and characteristics of stress granules
by Margo Brinton, PhD, Georgia State University
Mechanisms controlling Brucella intracellular parasitism
by Paul de Figueiredo, PhD, Texas A&M
Numerous reconciliations before divorce: The dynamic interactions of transcription factors with DNA
by Ridvan Nepravishta, PhD, UTMB
Taking the genetic basis for the response to hypoxia in human cardiomyocytes to heart
by Michelle Ward, PhD, UTMB
Structural Advancements toward understanding Ferlin proteins
by Bryan Sutton, PhD, Texas Tech University Health Sciences Center (TTUHSC), Lubbock
Mechanisms of Sex Disparities in Cardiac Development and Disease
by Frank Conlon, PhD, University of North Carolina at Chapel Hill
Somatic KRAS Gain of Function in Sporadic Brain Arteriovenous Malformations
by Joshua Wythe, PhD, Baylor College of Medicine
Regulation of gene expression in the brain by imprinted non-coding RNAs
by Amanda Whipple, PhD, Harvard University
Mechanisms controlling Brucella intracellular parasitism
by Paul de Figueiredo, PhD, Texas A&M University
Linking integrin shape-shifting with ligand interactions
by Mehmet Sen, PhD, University of Houston
Prospects of Cryo-EM at SCSB/UTMB
by Michael Sherman, PhD, UTMB
Protein Dynamics and Association Networks from LC-MS based Proteomics
by Rovshan Sadygov, PhD, UTMB
How does RNA Processing Influence Cell Fate Decisions?
by W. Sam Fagg, PhD, UTMB
Ins and outs: genome packaging and delivery in tailed bacteriophages
by Nikolai Prokhorov, PhD, UTMB
Protecting muscle mass and health: aging, exercise and nutrition
by Douglas Paddon-Jones, PhD, UTMB
The role of mitochondrial DNA polymerase in mtDNA deletions, disease and aging
by Bill Copeland, PhD, NIEHS
Integration of local and regional cis-regulatory information in the genome
by Barak Cohen, PhD, Washington University School of Medicine in St Louis
From Chip to Clinic: Integrating Advanced Physics and AI Approaches to Drug Challenging Targets
by Dr. Woody Sherman, Roivant Pharmaceuticals
Using Single-Cell Proteomics and Transcriptomics to Understand Gene Regulation
by Dr. Nikolai Slavov, Northeastern Univ
Evolution in coronaviruses driven by RNA recombination hotspots
by Dr. Andrew Routh, Univ Texas Medical Branch
Biomolecular condensates as organizers of biochemistry in bacteria
by Dr. Seth Childers, Univ Pittsburgh
AI in Drug Discovery, from the Clinic and Back
by Dr. Bissan Al-Lazikani, MD Anderson Cancer Center
Insights into Human Microbiomes from Micron-Scale Spatial Organization
by Dr. Jessica Mark Welch, Woods Hole Marine Biological Laboratory
Lord of the Broken Rings: how ATPase ring motors drive genome packaging in dsDNA viruses
by Dr. Marc Morais, Univ of Texas Medical Branch
Some assembly required: mechanistic studies of chromatin remodeling factors and histone chaperones
by Dr. Karolin Luger, Univ Colorado Boulder
Academic Drug Discovery: Challenges and Opportunities
by Dr. Zhiqiang An, McGovern Medical School
SARS-COV-2 biology and countermeasure development
by Dr. Xuping Xie, Univ Texas Medical Branch
Molecular regulation of muscle stem cell function
by Dr. Michael Rudnicki, Ottawa Health Research Institute
Mechanistic Insights of latent tumor suppressors promoting pancreatic cancer progression through transcriptional reprogramming
by Dr. Karen Mann, Moffitt Cancer Center
Super-resolution imaging of chromatin structure and dynamics in health and disease
by Dr. Melike Lakadamyali, Univ Pennsylvania
Global Optimization of Personalized Therapies for cancers, infectious diseases, and organ transplants
by Dr. Chih-Ming Ho, UCLA Samueli School Of Engineering
History dependent kinetics (memory) captured in sequential unfolding of polyproteins under tension
by Dr. Ronen Berkovich, Ben-Gurion University
Retrogenes and stranger things arising from host-virus interactions
by Dr. Nels Elde, Univ Utah
TRIM5a: Recognizing and Neutralizing the Retroviral Capsid
by Dr. Dmitri Ivanov, UT Health San Antonio
Environmental regulation of Lysosome Rich Enterocyte function
by Dr. Michel Bagnat, Duke Univ
Laboratory Diagnosis and Monitoring of Microbial Infections at Point of Care
by Dr. Yi-Wei Tang, Danaher Diagnostic
SARS-CoV-2 Immune Evasion and Countermeasure Development
by Dr. Hongjie Xia University of Texas Medical Branch
Understanding organism-wide coordination of growth by using spatiotemporal control of ribosome synthesis
by Dr. Elif Sarinay Cenik University of Texas at Austin
Single cell quantification of ribosome occupancy in early mouse development
by Dr. Can CenikUniversity of Texas at Austin
Nuclear organization by biomolecular condensates
by Dr. Ben Sabari University of Texas Southwestern
Force-regulated integrin spontaneous conformational changes
by Dr. Yunfeng Chen University of Texas Medical Branch
Immunodominance and antigenic evolution - lessons learned from influenza and SARS-CoV-2
by Dr. Seth Zost Vanderbilt University
Structures and functions of non-nonribosomal peptide synthetases
by Dr. Martin Schmeing McGovern Medical School
Mechano-Genomics: from Cell-State Transitions to Chromatin Biomarkers
by Dr. G.V. Shivashankar ETH Zurich & Paul Scherrer Institute
Balancing X-Chromosome Dosage in Hematopoietic Cells: Mechanistic Insights and Impact on Cancer
by Dr. Eda Yildirim Duke University
Chromatin-scaffolded phase separation in the nucleus
by Dr. Amy Strom Princeton University
The cellular orchestra of stress, innate immune, and programmed cell death signaling in health and disease
by Dr. Parimal Samir University of Texas Medical Branch
The Democratization of RNA Therapeutics: What it means for Infectious Diseases
by Dr. John Cooke Houston Methodist
C. elegans: platform for discovery about muscle assembly, maintenance, regulation & aging
by Dr. Guy Benian Emory University
Optical structural cell biology - visualising protein assemblies in cells with super-resolution microscopy
by Dr. Mike Heilemann Goethe-University
*Virtual only: Identifying common and rare regulatory variants in genetic disease
by Dr. Stephen Montgomery Stanford University
Mechanical basis of human disease
by Dr. Shang Ma University of Texas Southwestern
Mechanisms affected by Phospholipase D1 in the progression of neurogenerative states
by Dr. Balaji Krishnan University of Texas Medical Branch
Inferring gene regulatory divergence between humans and Neanderthals
by Dr. Tony Capra, University of California San Francisco
How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa
by Dr. Li-av Segev Zarko Stanford University
Overcoming Undruggable Targets Using Small Molecule Microarrays
by Dr. Bocheng Wu Massachusetts Institute of Technology
Genetic approaches to the p53 paradox
by Dr. Annika Wylie University of Texas Southwestern
Structural insights into the dynamic assembly pathway and function of the spliceosome
by Dr. Reinhard Lührmann Max Planck Institute for Multidisciplinary Sciences
Understanding metabolic disease through functional genomics
by Dr. Ewa Bielczyk-Maczyńska Stanford University
Collective Bacterial Motion on a Surface: Unexpected Insights into Antimicrobial Resistance
by Dr. Rasika Harshey University of Texas Austin
Investigating how homolog genome organization shapes gene regulatory programs
by Dr. Jumana AlHaj Abed Harvard University
Single cell multi-omic approaches to cardiac development and disease
by Dr. Sean Wu Stanford University
DNA methylation reprogramming in mammals
by Dr. Marisa Bartolomei University of Pennsylvania
Molecular mechanism of sound amplification
by Dr. Navid Bavi University of Chicago
EPAC signaling: Everything Everywhere All at Once
by Dr. Xiaodong C. Cheng, University of Texas Health Houston
Establishing advanced in vitro microphysiological platforms to evaluate cell and extracellular matrix remodeling
by Dr. Lauren Richardson University of Texas Medical Branch Galveston
Codon-specific ribosomal pausing in antiviral stress response
by Dr. Yan Xiang, University of Texas Health San Antonio
Mechanism of signal transduction across the bacterial cell envelope
by Dr. Anna Konovalova, University of Texas Health Medical Center Houston
From Interferon and Back Again: Antiviral Proteins for Treatments, Diagnostics and Vaccines
by Dr. Catherine Braun-Schein, University of Texas Medical Branch
Drugging Evolution of Antibiotic Resistance
by Dr. Susan Rosenberg , Baylor College of Medicine
Investigating targetable vulnerabilities of human tumors with complex genomic rearrangements
by Dr. Kadir Akdemir , MD Anderson
Dare to hide: Different facets of immunity in the host-pathogen arms race
by Dr. Naeha Subramanian, University of Washington
New High-Throughput Technologies to Understand the Molecular Basis of Membrane Penetration within the Rule of 5 and Beyond
by Dr. Juan Hu, University of California, Irvine
Pediatric Cryptosporidiosis: Engineering tissue-specific stability to develop a GI targeted parasiticidal agent
by Dr. Manjunatha Ujjini, Dr. Joseph Young Novartis Institutes for Biomedical Research (NIBR)
Development of countermeasures against highly pathogenic viruses
by Dr. Junki Maruyama, The University of Texas Medical Branch
The Shape of DNA
by Dr. Erez Lieberman Aiden, Baylor College of Medicine
Regenerative Therapies to Accelerate Wound Healing and Reduce Hypertrophic Scarring
by Dr. Amina El Ayadi, The University of Texas Medical Branch
Phosphoinositides orchestrate integrin trafficking and Cdc42 activity in the podosome
by Dr. Cheng-Han Yu, Hong Kong University
Targeted Mechanical Acceleration via Oscillating Head Motion Lowers Blood Pressure in Hypertensive Rats and Humans
by Dr. Yasuhiro Sawada, National Rehabilitation Center for Persons with Disabilities
Fungal-Bacterial Interaction in the Urinary Tract
by Dr. Alison Coady, The University of Texas Medical Branch
Molecule Allosteric Agonists of Integrin CD11b as Novel Therapeutics for Autoimmune Diseases
by Dr. Vineet Gupta, The University of Texas Medical Branch
Norovirus uses Metabolites and Structural Flexibility to Avoid the Immune System
by Dr. Thomas Smith, The University of Texas Medical Branch
From Tangled Mess to Ordered Structure: Unraveling the Mechanisms of 3D Genome Organization
by Dr. Eric Joyce, University of Pennsylvania
Diversity in Nonhuman Primates: Insights into Primate Evolution and Biomedical Applications
by Dr. Jeffrey Rogers, Baylor College of Medicine
Metal Mastery of Integrins
by Dr. Mehmet Sen, University of Houston
Dynamic Gene Regulation in Development and Disease: Using Single-Cell (and Multi-Cell) Genomics to Search for "Crouching Tigers" in the Human Genome
by Dr. Darren Cusanovich, University of Arizona
Catch Bonds and their Biological Relevance
by Dr. Cheng Zhu, Georgia Tech
Wave Front Shaping for Single Molecule Microscopy - Why and How to Ruin a Perfectly Good Microscope
by Dr. Yoav Shechtman, American Technion Society
EBF1 Drives Enhancer-Promoter Hubs in Lymphoma
by Dr. Babak Faryabi, University of Pennsylvania
Transcription Errors Drive Phenotypic Variability from E. coli to SARS-CoV-2
by Dr. Christophe Herman, Baylor College of Medicine
Kelly T. Hughes, PhD presents "The effect of tRNA structure and codon context on translation efficiency and fidelity"
by Kelly T. Hughes, PhD. Professor, University of Utah
Kathleen H. Burns, MD, PhD presents "A Retrotransposon in Cancer: The Marker and the Mutator"
by Kathleen H. Burns, MD, PhD
Grzegorz Ira, PhD presents "Unexpected links between mitochondria and nuclear genome stability"
by Grzegorz Ira, PhD. Professor, Baylor College of Medicine
Yann Robert Chemla, PhD presents "Single-molecule measurements of switch-like regulation in DNA processing machines"
by Speaker: Yann Robert Chemla, PhD
Lukasz Jaremko, PhD presents: Harnessing Dynamics and Small Organic Molecules with NMR and cryo-EM to Innovate Chemical Biology and Drug Discovery
by Lukasz Jaremko, PhD Associate Professor, King Abdullah University Host: Dr. Junji Iwahara
Marc-Jan Gubbels, PhD presents "Machinery and machination of Toxoplasma gondii cell division"
by Marc-Jan Gubbels, PhD
Michael Sheetz, PhD presents "Reversal of Aging by Low Frequency Ultrasound through YAP1"
Speaker: Michael Sheetz, PhD Professor Biochemistry & Molecular Biology
Igor Jouline, PhD presents "PAS and Cache: homologous small molecule binding sensors conserved from bacteria to humans"
by Igor Jouline, PhD, Professor of Microbiology at The Ohio State University.
Jochen Reiser, MD, PhD presents "The path is the goal: Physician-science and a potential new drug for kidney disease"
Speaker: Jochen Reiser, MD, PhD President Professor, Internal Medicine UTMB
Adam Rosenthal, PhD presents: Early lessons from single cell RNA seq of bacterial pathogens
by Adam Rosenthal, PhD Assistant Professor University of North Carolina, Chapel Hill Host: Dr. Linda Kenney
Junji Iwahara, PhD presents HMGB1: a DNA-binding protein as a danger signal in extracellular space
by Junji Iwahara PhD, Professor Dept. of Biochemistry & Molecular Biology Sealy Center for Structural Biology & Molecular Biophysics Host; Guy Nir, PhD
Laura Knoll, PhD presents "Modeling intestinal eukaryotic microbes in mice and microfluidic systems"
by Laura Knoll, PhD. Professor, University of Wisconsin, Madison
Brian Beliveau, PhD presents "Technologies for investigating chromatin structure in situ"
by Brian Beliveau, PhD, Assistant Professor of Genome Sciences from University of Washington
Venigalla B. Rao, PhD presents: Bacteriophage T4: an extraordinary model for deep learning of biological mechanisms and designing of future biomedicines
by Venigalla B. Rao, PhD, Professor, The Catholic University of America, Washington, D.C. Host: Dr. Petr Leiman
Stephanie Cologna, PhD presents "Mass spectrometry enabled proteomics and lipidomics reveal distinct biomarker signatures in Niemann-Pick Type C Disease"
by Stephanie Cologna, PhD, Assistant Professor, University of Illinois, Chicago
Charles Danko, PhD presents "Transcription as a lens for interpreting genome sequence"
by Charles Danko, PhD - Cornell University, College of Veterinary Medicine Associate Professor, Baker Institute for Animal Health Host: Dr. Michelle Ward
Lukasz Jaremko, PhD - faculty candidate - presents “Harnessing structural dynamics for next-gen chemical biology and drug discovery”
by Lukasz Jaremko, PhD, Associate Professor, Bioscience and Bioengineering, King Abdulla University of Science and Technology Host: Dr. Sanja Sever
Wenshe Ray Liu, PhD presents: Phage-Encoded Noncanonical Amino Acids for Epigenetic Drug Discovery
Speaker: Wenshe Ray Liu, PhD Texas A&M University Director, Texas A&M Drug Discovery Center Host: William Russell, PhD
Jordan Rowley, PhD presents "3D genome refolding in response to cellular cues"
by Jordan Rowley, PhD - University of Nebraska Medical Center
Barry Honig, PhD presents "Molecular Mechanisms Underlying the Precise Wiring of Neural Networks"
Speaker. Barry Honig, PhD Professor Columbia University Medical enter Host: Dr. Monte Pettitt
James Noonan PhD presents: Discovering the genetic drivers of uniquely human traits
Speaker: James Noonan, PhD Albert E. Kent Professor of Neuroscience Yale School of Medicine Host: Michelle Ward, PhD
Jeffrey Brodsky, PhD presents: The Role of Protein Quality Control and ER Associated Degradation (ERAD) in Disease
Speaker: Jeffrey Brodsky, PhD Avinoff Professor and Chair of Biological Sciences University of Pittsburgh Host: Parimal Samir, PhD
Antonio Bianco, MD, PhD presents: Localized T3 production and the Epigenome of the Adult Mouse Liver
Speaker: Antonio Bianco, MD, PhD Interim Senior Vice President and Dean, John Sealy School of Medicine Chief Research Officer Host: Sanja Sever, PhD
Andrew Fire, PhD presents: Opportunistic RNAs and Acquisitive Genomes
Speaker: Andrew Fire, PhD Nobel Laureate and Professor, Pathology and Genetics Stanford University School of Medicine Host: Dr. Whitney Yin
Yuhui Whitney Yin, PhD presents, Functional synergy in mitochondrial replisome and its implication in diseases
Speaker: Yuhui Whitney Yin, PhD Professor Biochemistry and Molecular Biology UTMB Host: Guy Nir, PhD
Sumitabha Brahmachari, PhD - Presents: Principles of Genome Architecture and Regulation
Speaker: Sumitabha Brahmachari , PhD - Postdoctoral Associate - Rice University Host: Erez Lieberman Aiden, PhD
Ismail Khater, PhD presents: TBA
Speaker: Ismail Khater, PhD Harvard Medical School Hosts: Guy Nir, PhD - Erez Lieberman Aiden, PhD
Christine Click
Maruyama Lab
Isabelle Bergman
El Ayadi Lab
Jaclyn McCoy
McBride Lab
Gabrielle Dewson
Nir Lab
Nicolette Valdez
Gagnon Lab
Brinley Harrington
Menon Lab
Justin Zhu
Sadygov Lab
Jessica Selim
Menon Lab
Justin Nguyen
Golovko Lab
Katherine Buchanan
Hommel Lab
Stephenie Rogers
Yin Lab
Dylan Smith
Chen Lab
David Beaver
Prideaux Lab
Dillon Nye, PhD presents: TBA
Principal Investigator RNA Biology New England Biolabs
Maisha Aniqua
Abbott Lab
TBD
Lab
TBD
Lab
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Seminars by Academic Year
Seminar Contacts
Chair
Dr. Guy Nir
Phone: (409) 772-3575
Email: niguy@utmb.edu
Coordinator
Vacant