I am a postdoctoral researcher working under the guidance of Professor Michael Sheetz at the University of Texas Medical Branch (UTMB) in Galveston. My work centers around investigating the role of mechanics in cellular senescence, tissue, and organism aging, and harnessing mechanical forces to enhance health and lifespan. My academic journey, spanning from stem cell maintenance to mechano-based rejuvenation, has uncovered novel insights and transformative treatments. During my doctoral research at the Indian Institute of Technology (IIT) Mumbai, under the supervision of Professor Abhijit Majumder, I focused on long-term stemness maintenance of human mesenchymal stem cells (hMSCs) in vitro. I demonstrated that culturing stem cells on soft surfaces preserved their differentiation capacity and proliferation rates, delaying replicative senescence. Our research also revealed that an initial culture on a soft surface followed by a switch to a stiff surface retained cellular and genomic stability in early passage stem cells. This finding has far-reaching implications for cell expansion and stability in therapeutic and research applications. In 2020, I joined Professor Sheetz's lab, where we developed a mechano-based method for rejuvenating senescent cells. Our work showcased rejuvenation effects in senescent fibroblasts and human mesenchymal stem cells (hMSCs), offering potential solutions for cellular aging. Notably, our research extended beyond cells to demonstrate improved physical performance in aging mice. This highlights the potential for clinical translation and underscores the significance of the findings. Currently, I am unraveling the molecular mechanisms underlying Low-Frequency Ultrasound (LFU)-mediated rejuvenation. Using advanced microscopy techniques, Machine learning models, and Single cells-omics, we are investigating the role of metabolic pathways, including AMPK, mTORC1, mitophagy, and autophagy. Preliminary results suggest that LFU activates autophagy through mitochondrial fission and lysosome redistribution, providing valuable insights into the rejuvenation process. Our work highlights the interplay between mechanical forces, cellular senescence, and rejuvenation. This can redefine our understanding of aging processes and inspire innovative therapeutic interventions. I hope that our findings will pave the way for advancements in promoting healthy aging and longevity.
September 2023 Spotlight: Dr. Sanjay Kumar Kureel
My aim in life is to solve the mysteries of aging and its associated side effects. I am passionate about understanding the mechanisms behind aging and finding innovative solutions to promote healthy aging and longevity. To make my dream come true, I am now looking to transition into the biotechnology industry and explore opportunities that align with my aspirations. Driven by a hunger for knowledge, I read books and actively seek to acquire new skills. I believe that continuous learning is key to staying at the forefront of scientific advancements and unlocking breakthroughs in the field of aging research.