Representative Recent Publications
1. Chen Y.*, Ju L. A.*,
Zhou F., Liao J., Xue L., Su Q. P., Jin D., Yuan Y., Lu H., Jackson S.
P., Zhu C., An integrin αIIbβ3 intermediate affinity state mediates
biomechanical platelet aggregation. Nature Materials 18(7):760-769
(2019) (*Co-first authored). --Commented by Nature Materials
(18(7):661–662) in the same issue
2. Chen Y.*†, Liao J.*, Yuan
Z., Li K., Liu B., Ju L. A., Zhu C.†, Fast force loading disrupts
molecular binding stability in human and mouse cell adhesions. Molecular
& Cellular Biomechanics 16(3):211-223 (2019) (*Co-first authored)
(†Co-correspondence). --Awarded Yuan-Cheng Fung Best Paper Award
3.
Chen Y., Ruggeri Z. M., Du X., 14-3-3 proteins in platelet biology and
glycoprotein Ib-IX signaling. Blood 131:2436-2448 (2018).
4. Zhou
F., Chen Y., Felner E. I., Zhu C. and Lu H., Microfluidic
auto-alignment of multiple protein patterns for dissecting
multi-receptor crosstalk. Lab on a Chip, 18:2966-2974 (2018).
5.
Chen Y., Lee H., Tong H., Schwartz M., Zhu C., Force regulated
conformational change of integrin αVβ3. Matrix Biology 60-61:70-85
(2017).
6. Ju L.*, Chen Y.*, Li K.*, Yuan Z., Liu B., Jackson S.
P., Zhu C., Dual Biomembrane Force Probe enables single-cell mechanical
analysis of signal crosstalk between multiple molecular species.
Scientific Reports, 7:14185 (2017). (*Co-first authored)
7. Ju
L.*, Chen Y.*, Xue L., Du X., Zhu C., Cooperative unfolding of
distinctive mechanoreceptor domains transduces force into signals. eLife
5:e15447 (2016) (*Co-first authored). --Featured in NSF Top Story
8.
Elosegui-Artola A., Oria R., Chen Y., Kosmalska A., Pérez-González C.,
Castro N., Zhu C., Trepat X., Roca-Cusachs P., Mechanical regulation of a
molecular clutch defines force transmission and transduction in
response to matrix rigidity. Nature Cell Biology 18(5):540-8 (2016).
9.
Rosetti F.*, Chen Y.*, Sen M., Thayer E., Azcutia V., Herter J. M.,
Luscinskas F. W., Cullere X., Zhu C., Mayadas T.N., A lupus-associated
Mac-1 variant has defects in integrin allostery and interaction with
ligands under force. Cell Reports 10, 1655-1664 (2015) (*Co-first
authored).
10. Chen Y.*, Liu B.*, Ju L.*, Hong, J.*, Ji Q., Chen
W., Zhu C., Fluorescence Biomembrane Force Probe: Concurrent
Quantitation of Receptor-Ligand Kinetics and Binding-induced
Intracellular Signaling on a Single Cell. Journal of Visualized
Experiments 102, e52975 (2015).