In the Journal of Brain Health, Jochen Reiser, MD, PhD, president of UTMB and CEO of the UTMB Health System; Harris Eyre, MD, PhD, a senior fellow at UTMB and a leading expert in brain health and the brain economy; and Mikele Epperly, PhD, MPH, vice president of Brain Health Transformation at UTMB, explore how principles of the emerging "brain economy" could reshape clinical care to better address the health challenges of the 21st century.