Mechanomedicine of Aging Symposium
1-5 PM on July 1, 2022 in HEC 3.222
Organized by Mechanomedicine Center
All UTMB Researchers Invited

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With the increase in lifespan from better medical treatments, there is great interest in mitigating the quality-of-life compromises that come with aging. Much evidence indicates that exercise inhibits many aging processes and does so through the mechanical reversal of senescence at a cellular level. We will explore some of the molecular mechanisms whereby exercise and other mechanical effects can an inhibitor reverse the senescence process.

We want to stimulate interactions at UTMB on the studies of aging with particular emphasis on the molecular mechanisms that can mitigate aging through exercise or other mechanical activities. Complex metabolic and signaling pathways are altered with cell senescence and the increase in the percentage of senescent cells with age underlies many aging abnormalities. These include diabetes, arthritis, susceptibility to infection, cardiovascular and other disorders.

Program

• 1:00-1:10 Introduction
• 1:10-1:50 Investigating Mechanisms and Treatment of Skeletal Musde Atrophy - presented by Plenary Prof. Chris Adams
• 1:50-2:20 Impaired Muscle Anabolism in Aging - presented by Prof. Blake Rasmussen
• 2:20-2:40 Consequences of Altered Chromatin Structure during MSC Aging: Increased Cryptic Transcription and Disrupted Super Enhancer-Promoter Looping - presented by Dr. Brenna McCauley
• 2:40-3:00 Increased Stem Cell Expansion by Ultrasound Rejuvenation of Senescence - presented by Dr. Sanjay Kureel
• 3:00-3:20 Break
• 3:20-3:50 Aging Regulation by Chromatin-Regulated Stress Response Mechanisms - presented by Assoc. Prof Weiwei Dang
• 3:50-4:20 The Significance of Sarcopenia - presented by Prof. Elena Volpi
• 4:20-4-40 Delineating the Role of Resilience in Non-human Primate Aging using Baboon Cell Models - presented by Dr. Daniel A. Adekunbi
• 4:40-5:10 Ultrasound Rejuvenation of Senescent Cells In Vitro and In Vivo - presented by Prof. Michael Sheetz
• 5:10-7:00 Reception