(Internet) 06/01/06 Vaccination with chimeric SIN/VEE viruses cleared Venezuelan equine encephalitis virus from the brains of animals. "None of the chimeric SIN/VEE viruses caused any detectable disease in adult mice after either intracerebral (i.c.) or subcutaneous (s.c.) inoculation, and all chimeras were more attenuated than the vaccine strain, VEEV TC83, in six-day-old mice after i.c. infection," said Slobodan Paessler and colleagues at the University of Texas Medical Branch in Galveston. "All vaccinated mice were protected against lethal encephalitis following i.c., s.c., or intranasal (i.n.) challenge with the virulent VEEV ZPC738 strain (ZPC738)."